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Adamantane-like molecules, Antiarrhythmic agents

Categories

Amidines (4)
Analgesics (4)
Bases (chemistry) (4)
Drugs acting on the cardiovascular system (4)
Drugs acting on the nervous system (4)
Guanidines (4)
Neurotoxins (4)
Sodium channel blockers (4)
Voltage-gated sodium channel blockers (4)

TETRODOTOXIN (4368-28-9)  
Tarichatoxin  ·  Tetradotoxin  ·  Fugu Toxin
Tarichatoxin (4368-28-9)  
Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin. Although tetrodotoxin was discovered in these fish and found in several other aquatic animals (e.g., in blue-ringed octopuses, rough-skinned newts, and moon snails), it is actually produced by certain infecting or symbiotic bacteria like Pseudoalteromonas, Pseudomonas, and Vibrio as well as other species found in the animals.

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Dofetilide (115256-11-6)  
Dofetilide is a class III antiarrhythmic agent. It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 µg of dofetilide. It is not available in Europe or Australia.
propafenone (107381-31-7, 107300-59-4, 54063-53-5, 107381-32-8)  
Rythmol  ·  Propafenone Hydrochloride  ·  Nistaken
Propafenone ( proh-PAF-i-nohn; brand name Rythmol SR or Rytmonorm) is a class 1C anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
flecainide (54143-55-4)  
Tambocor  ·  Flecainide Acetate  ·  Flecainide, 5-HO-N-(6-oxo)-Derivative, (+-)-Isomer
Flecainide acetate ( flek-AY-nyde) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart). It is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation (episodic irregular heartbeat originating in the upper chamber of the heart), paroxysmal supraventricular tachycardia (episodic rapid but regular heartbeat originating in the atrium), and ventricular tachycardia (rapid rhythms of the lower chambers of the heart). Flecainide works by regulating the flow of sodium in the heart, causing prolongation of the cardiac action potential.
Encainide (66778-36-7, 37612-13-8)  
Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.
RANOLAZINE (95635-55-5, 142387-99-3)  
Ranolazine, sold under the trade name Ranexa by Gilead Sciences, is a drug to treat angina that was first approved in 2006.
amiodarone (1951-25-3)  
Cordarone  ·  Amiodarone Hydrochloride  ·  Leurquin Brand of Amiodarone Hydrochloride
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. It can be given by mouth, intravenously, or intraosseously.
Cibenzoline (53267-01-9)  
cifenline  ·  cibenzoline succinate  ·  cifenline succinate
Cibenzoline (or cifenline) is a Class Ia antiarrhythmic. Pituxate & Ecipramidil are other gem-diphenyl cyclopropanyl drugs.
Tocainide hydrochloride (53984-76-2, 71395-14-7)  
Tocainide  ·  Tonocard  ·  W-36095
Ibutilide (122647-32-9, 122647-31-8)  
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents.
APRINDINE (37640-71-4)  
Fiboran  ·  Amidonal
Aprindine is a Class 1b antiarrhythmic agent. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.
tocainide (41708-72-9, 71395-14-7, 76213-25-7)  
Tonocard  ·  Tocainide Hydrochloride  ·  W-36095
Tocainide (Tonocard) is a class Ib antiarrhythmic agent. It is no longer sold in the United States.
Hydroquinidine hydrochloride (1476-98-8)  
hydroquinine  ·  dihydroquinidine  ·  hydroquinidine
522-66-7 (522-66-7)  
hydroquinine  ·  dihydroquinidine  ·  hydroquinidine
Dihydroquinine, also known as hydroquinine, is an organic compound and as a cinchona alkaloid closely related to quinine. The specific rotation is −148° in ethanol. A derivative of this molecule is used as chiral ligand in the AD-mix for Sharpless dihydroxylation.
hydroquinidine (1435-55-8, 522-66-7)  
hydroquinine  ·  dihydroquinidine  ·  dihydroquinine
Dihydroquinine, also known as hydroquinine, is an organic compound and as a cinchona alkaloid closely related to quinine. The specific rotation is −148° in ethanol. A derivative of this molecule is used as chiral ligand in the AD-mix for Sharpless dihydroxylation.
PROPAFENONE HYDROCHLORIDE (34183-22-7, 107381-35-1, 107381-36-2)  
Propafenone  ·  Rythmol  ·  Nistaken
Propafenone ( proh-PAF-i-nohn; brand name Rythmol SR or Rytmonorm) is a class 1C anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
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Adamantane-like molecules
Antiarrhythmic agents
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