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Anti-diabetic drugs

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Drugs acting on the gastrointestinal system and metabolism (29)
Cyclic compounds (18)
Pharmaceuticals (18)
Drugs acting on the cardiovascular system (13)
Antiarrhythmic agents (12)
Potassium channel blockers (12)
Sulfonylureas (11)
Six-membered rings (10)
PPAR agonists (8)
Thiazolidinediones (8)
Gastrointestinal system drug (7)
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Systemic hormonal preparations (5)
Alpha-glucosidase inhibitors (4)
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CYP17A1 inhibitors (4)
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Meglitinides (3)
Piperidines (3)
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Pioglitazone (111025-46-8)  
Actos  ·  pioglitazone hydrochloride  ·  U72,107A
Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione (TZD) class with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. While pioglitazone does decrease blood sugar levels, studies on the main cardiovascular outcomes have not yielded statistically significant results. Its cardiovascular safety profile compares favorably with that of rosiglitazone, which was withdrawn from some markets after concerns about an increased risk of cardiac events.
rosiglitazone (122320-73-4)  
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.
MIGLITOL (72432-03-2)  
Glyset  ·  BAY m 1099  ·  BAY-m 1099
Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to break down complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol, and other structurally-related iminosugars, inhibit glycoside hydrolase enzymes called alpha-glucosidases.
chlorpropamide (94-20-2)  
Diabinese  ·  Glucamide  ·  Clorpropamid
Chlorpropamide is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation sulfonylurea. It has more side effects than other sulfonylureas and its use is no longer recommended.
tolbutamide (64-77-7)  
Orinase  ·  Diabetol  ·  Rastinon
Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas.
acarbose (56180-94-0)  
Precose  ·  Glumida  ·  Bay g 5421
acetohexamide (968-81-0)  
Dymelor  ·  Dimelor  ·  Gamadiabet
Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.
METSULFURON-METHYL (74223-64-6)  
Metsulfuron-methyl is an organic compound classified as a sulfonylurea herbicide, which kills broadleaf weeds and some annual grasses. It is a systemic compound with foliar and soil activity, that inhibits cell division in shoots and roots. It has residual activity in soils, allowing it to be used infrequently but requiring up to 22 months before planting certain crops (sunflowers, flax, corn, or safflower).
troglitazone (97322-87-7)  
Troglitazone (Rezulin, Resulin, Romozin, Noscal) is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for patients with diabetes mellitus type 2. It was developed by Daiichi Sankyo (Japan).
PHENFORMIN (114-86-3)  
Fenformin  ·  Phenylethylbiguanide
Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was discovered in 1957 by Ungar, Freedman and Seymour Shapiro, working for the US Vitamin Corporation.
Torasemide (56211-40-6)  
Torasemide or torsemide is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand names Demadex, Diuver, and Examide.
glimepiride (684286-46-2, 93479-97-1)  
Amaryl  ·  Amarel  ·  Aventis brand of glimepiride
Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or as second-generation.
Carbutamide (339-43-5)  
Glucidoral  ·  Bucarban  ·  Oranyl
Carbutamide (brand name Glucidoral) is an anti-diabetic drug of the sulfonylurea class, developed by Servier. It is classified as first-generation.
voglibose (83480-29-9)  
Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose thereby reducing the risk of macrovascular complications. Voglibose is a research product of Takeda Pharmaceutical Company, Japan's largest pharmaceutical company.
Mitiglinide (145375-43-5, 207844-01-7)  
Mitiglinide (INN, trade name Glufast) is a drug for the treatment of type 2 diabetes. Mitiglinide belongs to the meglitinide (glinide) class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals.
Gliquidone (33342-05-1, 62783-47-5)  
gliquidone, monosodium salt  ·  gliquidone, calcium salt  ·  Beglynora
Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class. It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2.
Glisoxepide (25046-79-1)  
Pro-diaban  ·  4-(4-beta-(5-methylisoxazol-3-carboxamidoethyl)phenylsulfonyl)-1,1-hexamethylenesemicarbazide  ·  RP-22410
Glisoxepide (INN) is an orally available anti-diabetic drug from the group of sulfonylureas. It belongs to second-generation sulfonylureas.
Chlorproguanil (537-21-3)  
lapudrine  ·  unspecified HCl of chlorproguanil  ·  mono-HCl of chlorproguanil
ciglitazone (74772-77-3)  
5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione  ·  ADD-3878  ·  ciglitizone
Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones.
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