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Related to BUTACHLOR, Antiandrogens, Five-membered rings, Convulsants

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Antineoplastic and immunomodulating drugs (1)
Antineoplastic drugs (1)
Aromatase inhibitors (1)
Cyclic compounds (1)
Cycloalkenes (1)
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Estrogens (1)
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endosulfan (959-98-8, 33213-65-9, 115-29-7)  
Thiodan  ·  beta-Endosulfan  ·  Thiodon
Endosulfan is an off-patent organochlorine insecticide and acaricide that is being phased out globally. The two isomers, endo and exo, are known popularly as I and II. Endosulfan sulfate is a product of oxidation containing one extra O atom attached to the S atom.

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diethylstilbestrol (6898-97-1, 56-53-1, 22610-99-7, 64-67-5)  
Stilbestrol  ·  Distilbène  ·  Stilbene Estrogen
GANAXOLONE (38398-32-2)  
Ganaxolone is an experimental CNS-selective GABAA modulator that is under development by Marinus Pharmaceuticals as an anxiolytic and anticonvulsant agent. Ganaxolone has been shown to protect against seizures in animal models, and to act a positive allosteric modulator of the GABAA receptor. Ganaxolone is being investigated for potential medical use in the treatment of epilepsy.
picrotoxinin (17617-45-7)  
picrotoxinine
Pentylenetetrazol (54-95-5)  
Metrazol  ·  Cardiazol  ·  Pentylenetetrazole
Pentylenetetrazol, also known as pentylenetetrazole, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol or PTZ, is a drug formerly used as a circulatory and respiratory stimulant. High doses cause convulsions, as discovered by the Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934.
Allopregnanolone (128-20-1, 516-55-2)  
Pregnanolone  ·  3 alpha, 5 beta-Tetrahydroprogesterone  ·  Pregnanolone, (3beta, 5beta)-isomer
formestane (566-48-3)  
Formestane, sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced.
3,20-Allopregnanedione (566-65-4)  
5alpha-Pregnane-3,20-dione  ·  3,20-Allopregnanedione, (5beta,13alpha,17alpha)-Isomer  ·  5 alpha-Pregnane-3,20-dione
Tetrahydrodeoxycorticosterone (567-03-3, 567-02-2)  
THDOC  ·  5alpha-pregnan-3alpha,21-diol-20-one  ·  tetrahydrodeoxycorticosterone, (3alpha,5alpha)-isomer
Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects.
Gyki-52466 (102771-26-6)  
GYKI 52466  ·  1-(p-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
GYKI-52466 is a 2,3-benzodiazepine that acts as an ionotropic glutamate receptor antagonist, which is a non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively), orally-active anticonvulsant, and skeletal muscle relaxant. Unlike conventional 1,4-benzodiazepines, GYKI-52466 and related 2,3-benzodiazepines do not act on GABAA receptors. Like other AMPA receptor antagonists, GYKI-52466 has anticonvulsant and neuroprotective properties.
Pregnanolone (128-20-1)  
Pregnanolone, also known as eltanolone (INN), as well as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or 3α-hydroxy-5β-pregnan-20-one, is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for this reason was never marketed.
FADROZOLE (102676-47-1)  
Fadrozole (INN), sold under the brand name Afema (by Novartis), is a selective, nonsteroidal aromatase inhibitor which is or has been used in Japan for the treatment of breast cancer.
Mesulergine (64795-35-3)  
Mesulergine is a psychoactive drug of the ergoline chemical class that acts on serotonin and dopamine receptors. The compound had entered clinical trials for the treatment of Parkinson's disease; however, further development was halted due to adverse histological abnormalities in rats.
flutamide (13311-84-7)  
Eulexin  ·  Euflex  ·  SCH 13521
Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer. It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women. It is taken by mouth, usually three times per day.
pyrazole (288-13-1)  
1,2-diazole
Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).
Picrotoxinum (124-87-8)  
Picrotoxin
Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound. It was first isolated by the French pharmacist and chemist Pierre François Guillaume Boullay (1777–1869) in 1812. The name "picrotoxin" is a combination of the Greek words "picros" (bitter) and "toxicon" (poison).
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Antiandrogens
Five-membered rings
Convulsants
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