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Antimigraine drugs

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Analgesics (15)
Drugs acting on the nervous system (15)
Psychoactive drugs (10)
Cyclic compounds (7)
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Triptans (4)
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sumatriptan (103628-46-2)  
Sumatriptan is a medication used for the treatment of migraine and cluster headaches. It is a synthetic drug belonging to the triptan class. Structurally, it is an analog of psilocybin, and features a N-methyl sulfonamidomethyl group at position C-5 on the indole ring.
clonidine (4205-90-7)  
Catapres  ·  Clonidine Hydrochloride  ·  Dixarit
Clonidine (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, tic disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions. It is classified as a centrally acting α2 adrenergic agonist and imidazoline receptor agonist that has been in clinical use since 1966.
methysergide (361-37-5)  
Sansert  ·  Methysergide Maleate  ·  Deseril
Methysergide (1-methyl-D-lysergic acid butanolamide or UML-491) also known as methysergide maleate, is an ergot derived prescription drug used for the prophylaxis of difficult to treat migraine and cluster headaches. Methysergide is no longer recommended as a first line treatment protocol by international headache societies, hospitals, and neurologists in private practice, for migraines or cluster headaches as side effects were first reported with long-term use in the late 1960's, and ergot based treatments fell out of favor for the treatment of migraines with the introduction of triptans in the 1980's.
zolmitriptan (139264-17-8)  
Zolmitriptan is a selective serotonin receptor agonist of the 1B and 1D subtypes. It is a triptan, used in the acute treatment of migraine attacks with or without aura and cluster headaches. Zolmitriptan is marketed by AstraZeneca with the brand names Zomig, Zomigon (Argentina, Canada & Greece), AscoTop (Germany) and Zomigoro (France).
FONAZINE (7456-24-8)  
fonazine mesylate  ·  dimethothiazine  ·  Banistyl
Alniditan (152317-89-0)  
Alniditan is a 5-HT1D receptor agonist with migraine-preventative effects.
Tezampanel (154652-83-2)  
Tezampanel (INN, USAN) (code names LY-293,558, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant properties, the former of which may, at least in part, occur via blockade of calcium uptake into neurons. Tezampanel has a range of effects which may be useful for medicinal purposes, as well as its applications in scientific research.
Proxibarbal (2537-29-3, 42013-22-9, 42013-34-3)  
Axeen  ·  proxybarbital  ·  Ipronal
Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and in contrast to most barbiturates almost without hypnotic action. It was also used in the treatment of migraine headaches in a similar manner to butalbital.
UNII-T3XOS33TIQ (26020-55-3)  
6-(3-dimethylamino-1-propylidene) benzofuro(2,3-e)-12H-benzo(b)oxepine fumarate  ·  oxetorone  ·  Nocertone
Oxetorone (INN), as oxetorone fumarate (USAN) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug. Association with hyperprolactinemia has been described.
Donitriptan (170912-52-4)  
Donitriptan (INN) (code name F-11356) is a triptan drug which was investigated as an antimigraine agent but ultimately was never marketed. It acts as a high-affinity, high-efficacy/near-full agonist of the 5-HT1B (pKi = 9.4–10.1; IA = 94%) and 5-HT1D receptors (pKi = 9.3–10.2; IA = 97%), and is among the most potent of the triptan series of drugs. Donitriptan was being developed in France by bioMérieux-Pierre Fabre and made it to phase II clinical trials in Europe before development was discontinued.
Bromlysergamide (478-84-2)  
2-Bromo-LSD, also known as BOL-148, is a derivative of lysergic acid invented by Albert Hofmann, as part of the original research from which the closely related compound LSD was also derived. 2-bromo-LSD was found to be inactive as a psychedelic and so was comparatively little researched for many years, although its similar behavior in the body made it useful for radiolabelling studies. It was found to bind to many of the same receptor targets as LSD, but acting as a neutral antagonist rather than an agonist.
DOTARIZINE (84625-59-2)  
Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.
OXETORONE (26020-55-3)  
6-(3-dimethylamino-1-propylidene) benzofuro(2,3-e)-12H-benzo(b)oxepine fumarate  ·  Nocertone  ·  oxetorone fumarate, (E)-isomer
Oxetorone (INN), as oxetorone fumarate (USAN) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug. Association with hyperprolactinemia has been described.
lomerizine (101477-55-8)  
lomerizine dihydrochloride  ·  KB-2796  ·  KB 2796
Lomerizine (INN) (also known as KB-2796) is a diphenylpiperazine class L-type and T-type calcium channel blocker. This drug is currently used clinically for the treatment of migraines, while also being used experimentally for the treatment of glaucoma and optic nerve injury.