Similar to 1-(Methylamino)anthraquinone , Topoisomerase inhibitors
Cyclic compounds (1)
disperse red 9
Disperse Red 9, also called C.I. 60505 and 1-methylamino anthraquinone, is a red dye derived from anthraquinone. Disperse Red 9 is used in some older red and violet-red colored smoke formulations.
Pixantrone (144510-96-3, 144675-97-8)
Pixantrone (rINN; trade name Pixuvri) is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent. The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials.
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E.
transplatin · trans-diamminedichloroplatinum II · trans-DDP
tulipalin A · alpha-methylene gamma-butyrolactone
Protein kinase inhibitor H-8 (84478-11-5)
H8 protein kinase inhibitor · N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide · H-8 protein kinase inhibitor
MS 275 · MS-27-275 · N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide
Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers. Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. Syndax pharmaceuticals currently holds the rights to Entinostat and recently received $26.6 million in funds to advance treatments of resistant cancers using epigenetic tools.
Angiotensin amide (53-73-6)
Hypertensin · 5-Valine-Angiotensin II Amide · 1 Asparagine 5 valine Angiotensin II
Angiotensinamide (INN; BAN and USAN angiotensin amide) is a potent vasoconstrictor used as a cardiac stimulant. It is a derivative of angiotensin II.
Dacogen · 5-deoxyazacytidine · 2'-deoxy-5-azacytidine
Decitabine (trade name Dacogen), or 5-aza-2'-deoxycytidine, acts as an Nucleic Acid Synthesis Inhibitor. It is a drug for the treatment of myelodysplastic syndromes, a class of conditions where certain blood cells are dysfunctional, and for acute myeloid leukemia (AML). Chemically, it is a cytidine analog.
4(3H)-quinazolinone · quinazolin-4-one
SP600125 · anthra(1,9-cd)pyrazol-6(2H)-one · NSC75890
1,9-Pyrazoloanthrone is a chemical compound that is a derivative of anthrone. It is used in biochemical studies as an inhbitor of c-Jun N-terminal kinases (JNKs). Derivatives of 1,9-pyrazoloanthrone have a variety of biological activities.
NSC-666096 · ethanol, 2-((9-methyl-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-
Glial scar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system. As with scarring in other organs and tissues, the glial scar is the body's mechanism to protect and begin the healing process in the nervous system. In the context of neurodegeneration, formation of the glial scar has been shown to have both beneficial and detrimental effects.