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Cholinergics

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Nicotine (54-11-5)  
Nicotine Tartrate  ·  Nicotine Bitartrate
Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants. Nicotine acts as an agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist. Nicotine is found in the leaves of Nicotiana rustica, in amounts of 2–14%; in the tobacco plant, Nicotiana tabacum; in Duboisia hopwoodii; and in Asclepias syriaca.
3-(1-methylpyrrolidin-2-yl)pyridine (22083-74-5, 54-11-5)  
Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants. Nicotine acts as an agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist. Nicotine is found in the leaves of Nicotiana rustica, in amounts of 2–14%; in the tobacco plant, Nicotiana tabacum; in Duboisia hopwoodii; and in Asclepias syriaca.
2-(Dimethylamino)ethanol (108-01-0)  
Dimethylaminoethanol and dimethylethanolamine (DMAE and DMEA respectively), with deanol, are common names for 2-(dimethylamino)ethanol.
Varenicline (249296-44-4)  
Varenicline (trade name Chantix and Champix), is a prescription medication used to treat nicotine addiction. It both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. It is a high-affinity partial agonist for the α4β2 nicotinic acetylcholine receptor subtype (nACH) that leads to the release of dopamine in the nucleus accumbens when activated, and therefore, has the capacity to reduce the feelings of craving and withdrawal caused by smoking cessation.
galanthamine (23173-12-8, 357-70-0)  
Galantamine (Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. It is an alkaloid that has been isolated from the bulbs and flowers of Galanthus caucasicus (Caucasian snowdrop), Galanthus woronowii (Voronov's snowdrop), and some other members of the family Amaryllidaceae, such as Narcissus (daffodil), Leucojum aestivum (snowflake), and Lycoris including Lycoris radiata (red spider lily). It can also be produced synthetically.
cotinine (486-56-6)  
Scotine
Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine. Cotinine is used as a biomarker for exposure to tobacco smoke. Cotinine is currently being studied as a treatment for depression, PTSD, schizophrenia, Alzheimer's disease and Parkinson's disease.
CYTISINE (485-35-8)  
Tsitizin  ·  cytisine hydrochloride, hydrate  ·  cytisine hydrochloride
Cytisine, also known as baptitoxine and sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation. Its molecular structure has some similarity to that of nicotine and it has similar pharmacological effects.
carbachol (51-83-2, 74-97-5)  
Carbamylcholine  ·  Doryl  ·  Miostat
Carbachol (Carbastat, Carboptic, Isopto Carbachol, Miostat), also known as carbamylcholine, is a cholinomimetic drug that binds and activates the acetylcholine receptor. Thus it is classified as a cholinergic agonist. It is primarily used for various ophthalmic purposes, such as for treating glaucoma, or for use during ophthalmic surgery.
choline (62-49-7)  
Choline Chloride  ·  Choline Bitartrate  ·  Choline Citrate
Choline is a water-soluble vitamin-like essential nutrient. It is a basic constituent of lecithin, which is present in many plants and animal organs. The term cholines refers to the class of quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation (X− on the right denotes an undefined counteranion).
Succinylcholine chloride (71-27-2)  
Succinylcholine  ·  Suxamethonium  ·  Anectine
Suxamethonium chloride, also known as suxamethonium or succinylcholine, is a medication used to cause short-term paralysis as part of general anesthesia. This is done to help with tracheal intubation or electroconvulsive therapy. It is given either by injection into a vein or muscle.
pilocarpine (92-13-7, 54-71-7)  
Pilocarpine Hydrochloride  ·  Ocusert  ·  Pilocarpine Nitrate
Pilocarpine is a medication used to treat increased pressure inside the eye and dry mouth. As eye drops it is used for angle closure glaucoma until surgery can be performed, ocular hypertension, open angle glaucoma, and to bring about constriction of the pupil following their dilation. Onset of effects with the drops is typically within an hour and lasts for up to a day.
Cevimeline (107233-08-9)  
Cevimeline (trade name Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M1 and M3 receptors. It is used in the treatment of dry mouth and especially associated with Sjögren's syndrome.
3-(piperidin-2-yl)pyridine (494-52-0, 13078-04-1)  
Anabasine is a pyridine and piperidine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, a close relative of the common tobacco plant (Nicotiana tabacum). It is a structural isomer of, and chemically similar to, nicotine. Its principal (historical) industrial use is as an insecticide.
124620-88-8 (124620-88-8)  
Cevimeline (trade name Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M1 and M3 receptors. It is used in the treatment of dry mouth and especially associated with Sjögren's syndrome.
(-)-Anabasine (494-52-0)  
Anabasine  ·  Neonicotine
Anabasine is a pyridine and piperidine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, a close relative of the common tobacco plant (Nicotiana tabacum). It is a structural isomer of, and chemically similar to, nicotine. Its principal (historical) industrial use is as an insecticide.
levamisole (14769-73-4)  
Levamisole Hydrochloride  ·  Decaris  ·  Dekaris
Levamisole, sold under the trade name Ergamisol among others, is a medication used to treat parasitic worm infections. Specifically it is used for ascariasis and hookworm infections. It is taken by mouth.
PYRANTEL (15686-83-6, 15755-53-0)  
Pyrantel is a medication used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. It is taken by mouth.
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