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DNA replication inhibitors

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Antineoplastic and immunomodulating drugs (78)
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etoposide (33419-42-0)  
VP16  ·  Vepesid  ·  VP 16
melphalan (1465-26-5, 148-82-3)  
Alkeran  ·  Phenylalanine Mustard  ·  Sarcolysine
Melphalan (trade name Alkeran, in former USSR also known as Sarcolysin) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.
lomustine (13010-47-4)  
CCNU  ·  CeeNU  ·  NSC-79037
Lomustine (INN), abbreviated CCNU (original brand name (formerly available) is CeeNU, now marketed as Gleostine), is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood-brain barrier.
busulfan (55-98-1)  
Myleran  ·  Busulphan  ·  Busulfex
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a cancer drug, in use since 1959. Busulfan is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate.
bleomycin (11056-06-7)  
Bleomycin is a medication used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. Typically used with other cancer medications, it can be given intravenously, by injection into a muscle or under the skin.
chlorambucil (305-03-3)  
Leukeran  ·  CB 1348  ·  Lympholysin
Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given by mouth.
Merphalan (531-76-0)  
Melphalan  ·  Alkeran  ·  Phenylalanine Mustard
mechlorethamine (51-75-2, 538-07-8)  
Nitrogen Mustard  ·  Mustargen  ·  Mechlorethamine Hydrochloride
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) Embichin (эмбихин), is a nitrogen mustard sold under the brand name Mustargen. It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication.
STREPTOZOTOCIN (18883-66-4, 66395-18-4)  
Streptozocin  ·  Zanosar  ·  2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose
Isobleomycin A2 (11056-06-7)  
Bleomycin is a medication used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. Typically used with other cancer medications, it can be given intravenously, by injection into a muscle or under the skin.
streptozocin (18883-66-4, 66395-18-4)  
Streptozotocin  ·  Zanosar  ·  2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose
Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. It is used in medicine for treating certain cancers of the islets of Langerhans and used in medical research to produce an animal model for hyperglycemia in a large dose, as well as type 2 diabetes or type 1 diabetes with multiple low doses.
bleomycin a2 (11056-06-7, 11116-31-7)  
Bleomycin  ·  Blenoxane  ·  Bleomycin Sulfate
Bendamustine (16506-27-7)  
Bendamustine, sold under the brand name Treanda among others, is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. It is given by injection into a vein. Common side effects include low blood cell counts, fever, nausea, diarrhea, loss of appetite, cough, and rash.
Teniposido (29767-20-2)  
Teniposide  ·  Vumon  ·  VM26
Teniposide (trade name Vumon) is a chemotherapeutic medication used in the treatment of childhood acute lymphocytic leukemia (ALL), Hodgkin's lymphoma, certain brain tumours, and other types of cancer. It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.
Bis(2-chloroethyl)ethylamine (538-07-8)  
Bis(2-chloroethyl)ethylamine is the organic compound with the formula C2H5N(CH2CH2Cl)2. Often abbreviated HN1, it is a powerful vesicant and a nitrogen mustard gas used for chemical warfare. HN1 was developed in the 1920s and 1930s to remove warts and later as a military agent.
teniposide (29767-20-2)  
Vumon  ·  VM26  ·  VM 26
Teniposide (trade name Vumon) is a chemotherapeutic medication used in the treatment of childhood acute lymphocytic leukemia (ALL), Hodgkin's lymphoma, certain brain tumours, and other types of cancer. It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.
thiotepa (52-24-4)  
Triethylenethiophosphoramide  ·  Tespa  ·  Thio Tepa
Thiotepa (INN, chemical name: N,N′,N′′-triethylenethiophosphoramide) is an alkylating agent used to treat cancer. Thiotepa is an organophosphorus compound with the formula SP(NC2H4)3. It is a analog of N,N′,N′′-triethylenephosphoramide (TEPA), which contains tetrahedral phosphorus and is structurally akin to phosphate.
altretamine (645-05-6)  
Hemel  ·  Hexamethylmelamine  ·  Hexalen
Altretamine (trade name Hexalen) is an antineoplastic agent. It was approved by the U.S. FDA in 1990.
trichlormethine (555-77-1)  
Tris(2-chloroethyl)amine is the organic compound with the formula N(CH2CH2Cl)3. Often abbreviated HN3, it is a powerful blister agent and a nitrogen mustard gas (although it is not a gas) used for chemical warfare. HN3 was the last of the nitrogen mustard agents developed.
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