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Disulfiram-like drugs


Drugs acting on the nervous system (43)
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Sigma Aldrich (19)
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SynQuest Laboratories (1)
Toronto Research Chemicals (1)

chloral hydrate (302-17-0)  
Chloral hydrate is a geminal diol with the formula C2H3Cl3O2. It is a colorless solid. It has limited use as a sedative and hypnotic pharmaceutical drug.
Disulfiram (97-77-8)  
Antabuse  ·  Tetraethylthiuram Disulfide  ·  Antabus
Disulfiram (sold under the trade names Antabuse and Antabus) is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, which means that many of the effects of a "hangover" are felt immediately after alcohol is consumed. "Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion.
Phenylbutazone (50-33-9)  
Butazolidin  ·  Butadione  ·  Butapyrazole
Phenylbutazone, often referred to as "bute," is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals. In the United States and United Kingdom it is no longer approved for human use (except for ankylosing spondylitis, because no other treatment is available), as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the 2013 meat adulteration scandal.
nitroglycerin (55-63-0)  
Dynamite  ·  Glyceryl Trinitrate  ·  Nitrostat
Nitroglycerin (NG), also known as nitroglycerine, trinitroglycerin (TNG), trinitroglycerine, nitro, glyceryl trinitrate (GTN), or 1,2,3-trinitroxypropane, is a heavy, colorless, oily, explosive liquid most commonly produced by nitrating glycerol with white fuming nitric acid under conditions appropriate to the formation of the nitric acid ester. Chemically, the substance is an organic nitrate compound rather than a nitro compound, yet the traditional name is often retained. Invented in 1847, nitroglycerin has been used as an active ingredient in the manufacture of explosives, mostly dynamite, and as such it is employed in the construction, demolition, and mining industries.
isoniazid (54-85-3)  
Isonicotinic Acid Hydrazide  ·  Tubazide  ·  Isonex
Isoniazid, also known as isonicotinylhydrazide (INH), is an antibiotic used for the treatment of tuberculosis. For active tuberculosis it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol. For latent tuberculosis it is often used by itself.
phenacetin (62-44-2)  
Phenacetin (or acetophenetidin) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in 1887 and the 1983 ban imposed by the U.S. Food and Drug Administration.
CYANAMIDE (156-62-7, 420-04-2, 2669-76-3)  
Calcium Cyanamide  ·  Carbimide  ·  Colme
Cyanamide is an organic compound with the formula CN2H2. This white solid is widely used in agriculture and the production of pharmaceuticals and other organic compounds. It is also used as an alcohol-deterrent drug in Canada, Europe and Japan.
chloramphenicol (56-75-7, 2787-09-9)  
Chloromycetin  ·  Ophthochlor  ·  Cloranfenicol
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever.
abacavir (136470-78-5, 188062-50-2, 79804-71-0)  
Abacavir (ABC) is a medication used to prevent and treat HIV/AIDS. Similar to other nucleoside reverse transcriptase inhibitors (NRTIs), abacavir is used together with other HIV medications, and is not recommended by itself. It is taken by mouth as a tablet or solution and may be used in children over the age of three months.
nitrofurantoin (67-20-9)  
Furadantin  ·  Macrodantin  ·  Furantoin
Nitrofurantoin, sold under the trade name Macrobid among others, is an antibiotic used to treat bladder infections. It is not effective for kidney infections. It is taken by mouth.
chlorpropamide (94-20-2)  
Diabinese  ·  Glucamide  ·  Clorpropamid
Chlorpropamide is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation sulfonylurea. It has more side effects than other sulfonylureas and its use is no longer recommended.
quinacrine (69-05-6, 78901-94-7, 83-89-6)  
Atabrine  ·  Mepacrine  ·  Atebrin
Mepacrine (INN), also called quinacrine (USAN) or by the trade name Atabrine, is a drug with several medical applications. It is related to chloroquine and mefloquine.
Edecrin  ·  Ethacrynate Sodium  ·  Ethacrinic Acid
Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure. Unlike the other loop diuretics, etacrynic acid is not a sulfonamide and thus, its use is not contraindicated in those with sulfa allergies. Ethacrynic acid is a phenoxyacetic acid derivative containing a ketone group and a methylene group.
tolbutamide (64-77-7)  
Orinase  ·  Diabetol  ·  Rastinon
Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas.
tinidazole (19387-91-8)  
Fasigyn  ·  Farmasierra Brand of Tinidazole  ·  Fasigyne
Tinidazole is an anti-parasitic drug used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of amoebic and parasitic infections. It was developed in 1972.
phentolamine (50-60-2)  
Regitine  ·  Phentolamine Mesylate  ·  Rogitine
Phentolamine (Regitine) is a reversible nonselective α-adrenergic antagonist.
furazolidone (67-45-8)  
Furoxone  ·  Furazolidine  ·  Furazol
Furazolidone is a nitrofuran antibacterial agent and monoamine oxidase inhibitor (MAOI). It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.
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