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Drugs acting on the respiratory system, Cyclic compounds

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Respiratory system drug (83)
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codeine (52-28-8, 76-57-3)  
Codeine Phosphate  ·  Isocodeine  ·  Ardinex
Isocodeine is an opioid research chemical related to codeine. It is an epimer of codeine that can be prepared from it by a Mitsunobu reaction. Dozens of derivatives and analogs of isocodeine and the related compound isomorphine have been produced.
azelastine (58581-89-8)  
Astelin  ·  Optivar  ·  azelastine hydrochloride
Azelastine is a potent, second-generation, selective, histamine antagonist (histamine-H1-receptor antagonist) used as a first line therapy of mild intermittent, moderate/severe intermittent and mild persistent rhinitis (new classification system for rhinitis). Azelastine has been formulated both as a nasal spray and as eye drops and are available worldwide under many brand names.
PIRFENIDONE (53179-13-8)  
Pirfenidone is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. It was developed by several companies worldwide, including the original patent holder, Marnac, InterMune Inc.
BROMPHENIRAMINE (86-22-6)  
Dimetane  ·  Brompheniramine Maleate  ·  Chlorphed
Brompheniramine (Bromfed, Dimetapp, Bromfenex, Dimetane, BPN, Lodrane), commonly marketed as its salt brompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.
chlorpheniramine (113-92-8, 32188-09-3, 132-22-9)  
Chlorpheniramine Maleate  ·  Teldrin  ·  Piriton
Chlorphenamine (also known as chlorpheniramine, CP, or CPM) is a first-generation antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorphenamine is one of the most commonly used antihistamines in small-animal veterinary practice.
METHDILAZINE (1982-37-2)  
methdilazine hydrochloride
Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.
ketorolac (66635-83-4, 74103-06-3)  
Ketorolac, sold under the brand name Toradol among others, is a nonsteroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives, used as an analgesic. It is considered a first-generation NSAID. Ketorolac acts by inhibiting the bodily synthesis of prostaglandins.
antazoline (91-75-8)  
Antistine  ·  Antazoline Phosphate  ·  Antazoline Hydrochloride
Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. To treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline. The drug is a Histamine H1 receptor antagonist: selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.
thiethylperazine (1420-55-9, 1179-69-7)  
Torecan  ·  Norzine  ·  Novartis Brand of Thiethlperazine Maleate
Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects. Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.
methapyrilene (91-80-5)  
Thionylan  ·  Lullamin  ·  Tenalin
tetrahydrozoline (84-22-0)  
Visine  ·  tetrahydrozoline hydrochloride  ·  Tyzine
Tetryzoline (INN; also known as tetrahydrozoline), a derivative of imidazoline, is found in over-the-counter eye drops and nasal sprays. Other derivatives include naphazoline, oxymetazoline, and xylometazoline. Tetrahydrozoline is an alpha agonist and its main mechanism of action is the constriction of conjunctival blood vessels.
DEXCHLORPHENIRAMINE (25523-97-1)  
Polaramine  ·  dexchlorpheniramine maleate  ·  Polaramin
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
pyrilamine (59-33-6, 91-84-9)  
Mepyramine  ·  Pyrilamine Maleate  ·  Anthisan
Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties.
chlorcyclizine (82-93-9)  
chlorcycline  ·  chlorocyclizin  ·  Histachlorazine
Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine also has some anticholinergic, antiserotonergic, and local anesthetic properties.
Roflumilast (162401-32-3)  
Roflumilast (trade names Daxas, Daliresp) is a drug that acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). It has anti-inflammatory effects and is used as an orally administered drug for the treatment of inflammatory conditions of the lungs such as chronic obstructive pulmonary disease (COPD). In June 2010, it was approved in the EU for severe COPD associated with chronic bronchitis.
Pemirolast (69372-19-6, 100299-08-9)  
Pemirolast (INN) is a mast cell stabilizer used as an anti-allergic drug therapy. It is marketed under the tradenames Alegysal and Alamast. Clinical trials studying treatments for allergic conjunctivitis have found that an ophthalmic solution containing levocabastine with pemirolast potassium may be more effective in alleviating symptoms than levocabastine alone.
NEDOCROMIL (69049-73-6)  
Nedocromil sodium is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well-known inhaler medications) and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.
carbinoxamine (5560-77-0, 486-16-8)  
carbinoxamine maleate  ·  Histex PD  ·  Histex CT
Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid.
doxapram (309-29-5)  
Dopram  ·  Doxapram Hydrochloride  ·  Genopharm Brand of Doxapram Hydrochloride
Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
clenbuterol (50306-01-9, 37148-27-9, 50499-60-0, 50306-03-1)  
NAB 365  ·  NAB365  ·  Planipart
Clenbuterol, marketed as Dilaterol, Spiropent, Ventipulmin, is a sympathomimetic amine used by sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders such as asthma use this as a bronchodilator to make breathing easier. It is most commonly available as the hydrochloride salt, clenbuterol hydrochloride.
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