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Drugs acting on the respiratory system, PDE4 inhibitors

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Antiasthmatic drugs (15)
Respiratory agents (15)
Pharmaceuticals (7)
Alkaloids (4)
Antitussives (4)
Drugs acting on the nervous system (3)
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Roflumilast (162401-32-3)  
Roflumilast (trade names Daxas, Daliresp) is a drug that acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). It has anti-inflammatory effects and is used as an orally administered drug for the treatment of inflammatory conditions of the lungs such as chronic obstructive pulmonary disease (COPD). In June 2010, it was approved in the EU for severe COPD associated with chronic bronchitis.
pentoxifylline (6493-05-6)  
Trental  ·  Torental  ·  Pentoxil
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It is generic and sold under many brand names worldwide.
drotaverine (14009-24-6, 985-12-6)  
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth. It is structurally related to papaverine, is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects. It is available in Asian and Eastern European countries under several brand names.
luteolin (491-70-3)  
Luteoline  ·  3',4',5,7-Tetrahydroxy-Flavone  ·  3',4',5,7-Tetrahydroxyflavone
Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance.
Piclamilast (144035-83-6)  
Piclamilast (RP 73401), is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma.
rolipram (61413-54-5)  
ZK 62711  ·  ZK62711  ·  ZK-62711
Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It served as a prototype molecule for several companies' drug discovery and development efforts. Rolipram was discontinued after clinical trials showed that its therapeutic window was too narrow; it could not be dosed at high enough levels to be effective without causing significant gastrointestinal side effects.
propentofylline (55242-55-2)  
HWA 285  ·  1-(5'-oxohexyl)-3-methyl-7-propylxanthine  ·  HWA-285
Propentofylline (HWA 285) is a xanthine derivative with purported neuroprotective effects.
Cilomilast (153259-65-5)  
Cilomilast (INN, codenamed SB-207,499, proposed trade name Ariflo) is a drug which was developed for the treatment of respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD). It is orally active and acts as a selective phosphodiesterase-4 inhibitor. Phosphodiesterase (PDE) inhibitors, such as theophylline, have been used to treat COPD for centuries; however, the clinical benefits of these agents have never been shown to outweigh the risks of their numerous adverse effects.
Glaucine (475-81-0)  
glaucine phosphate (5:7), (+-)-isomer  ·  glaucine acetate, (+-)-isomer  ·  glaucine phosphate (2:3), (S)-isomer
Glaucine is an alkaloid found in several different plant species in the Papaveraceae family such as Glaucium flavum, Glaucium oxylobum and Corydalis yanhusuo, and in other plants like Croton lechleri in the family Euphorbiaceae. It has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries. Glaucine may produce side effects such as sedation, fatigue, and a hallucinogenic effect characterised by colourful visual images, and has been detected as a novel psychoactive drug.
etazolate (51022-77-6)  
SQ 20009  ·  SQ-20009  ·  SQ20009
Etazolate (SQ-20,009, EHT-0202) is an anxiolytic drug which is a pyrazolopyridine derivative and has unique pharmacological properties. It acts as a positive allosteric modulator of the GABAA receptor at the barbiturate binding site, as an adenosine antagonist of the A1 and A2 subtypes, and as a phosphodiesterase inhibitor selective for the PDE4 isoform. It is currently in clinical trials for the treatment of Alzheimer's disease.

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1,3,5-tris(3-isocyanato-4-methylphenyl)-1,3,5-triazinane-2,4,6-trione (26603-40-7, 8060-82-0)  
brobenzoxaldine, broxyquinoline drug combination  ·  Intestopan  ·  Enteroquin
AEIQS (84468-17-7)  
N-(2-aminoethyl)-5-isoquinolinesulfonamide  ·  H-9  ·  protein kinase C inhibitor H-9
Protein kinase inhibitor H-8 (84478-11-5)  
H8 protein kinase inhibitor  ·  N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide  ·  H-8 protein kinase inhibitor
121-30-2 (121-30-2)  
2-ACBDS  ·  2-amino-4-chloro-m-benzenedisulfonamide  ·  4-amino-6-chloro-1,3-benzenedisulfonamide
thalidomide (50-35-1)  
Thalomid  ·  Celgene Brand of Thalidomide  ·  Sedoval
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs. Today, thalidomide is used mainly as a treatment of certain cancers (multiple myeloma) and of a complication of leprosy. Thalidomide was first marketed in 1957 in West Germany under the trade-name Contergan.
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Drugs acting on the respiratory system
PDE4 inhibitors
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