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Drugs acting on the respiratory system, Six-membered rings

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Cyclic compounds (59)
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PIRFENIDONE (53179-13-8)  
Pirfenidone is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. It was developed by several companies worldwide, including the original patent holder, Marnac, InterMune Inc.
BROMPHENIRAMINE (86-22-6)  
Dimetane  ·  Brompheniramine Maleate  ·  Chlorphed
Brompheniramine (Bromfed, Dimetapp, Bromfenex, Dimetane, BPN, Lodrane), commonly marketed as its salt brompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.
chlorpheniramine (113-92-8, 32188-09-3, 132-22-9)  
Chlorpheniramine Maleate  ·  Teldrin  ·  Piriton
Chlorphenamine (also known as chlorpheniramine, CP, or CPM) is a first-generation antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorphenamine is one of the most commonly used antihistamines in small-animal veterinary practice.
thiethylperazine (1420-55-9, 1179-69-7)  
Torecan  ·  Norzine  ·  Novartis Brand of Thiethlperazine Maleate
Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects. Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.
methapyrilene (91-80-5)  
Thionylan  ·  Lullamin  ·  Tenalin
DEXCHLORPHENIRAMINE (25523-97-1)  
Polaramine  ·  dexchlorpheniramine maleate  ·  Polaramin
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
pyrilamine (59-33-6, 91-84-9)  
Mepyramine  ·  Pyrilamine Maleate  ·  Anthisan
Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties.
chlorcyclizine (82-93-9)  
chlorcycline  ·  chlorocyclizin  ·  Histachlorazine
Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine also has some anticholinergic, antiserotonergic, and local anesthetic properties.
carbinoxamine (5560-77-0, 486-16-8)  
carbinoxamine maleate  ·  Histex PD  ·  Histex CT
Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid.
doxapram (309-29-5)  
Dopram  ·  Doxapram Hydrochloride  ·  Genopharm Brand of Doxapram Hydrochloride
Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
AZATADINE (3964-81-6)  
Azatadine (Optimine) is a first-generation antihistamine and anticholinergic that was launched Schering-Plough in 1973. It was patented in 1967. It has been succeeded by other antihistamines and marketing approvals have been widely withdrawn.
diphenylpyraline (147-20-6)  
diphenylpyraline hydrochloride  ·  diphenylpyraline maleate (2:1)  ·  Lergobine
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents.
Dexbrompheniramine (132-21-8)  
dexbrompheniramine maleate  ·  Disophrol
Dexbrompheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada.
Chloropyrilene (148-65-2)  
Chlorothen (trade name Thenclor) is an antihistamine and anticholinergic.
Bepotastine (125602-71-3)  
Bepotastine (Talion, Bepreve) is a 2nd generation antihistamine. It was approved in Japan for use in the treatment of allergic rhinitis and urticaria/pruritus in July 2000 and January 2002, respectively. It is currently marketed in the United States under the brand-name Bepreve, by ISTA Pharmaceuticals.
Buclizine (82-95-1, 163837-52-3, 163837-51-2)  
buclizine hydrochloride  ·  Softran  ·  Stuart brand 1 of buclizine dihydrochloride
Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine. In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.
dyclonine (586-60-7)  
Sucrets  ·  Dyclone  ·  dyclonine hydrochloride
Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.
Nikethamide (59-26-7)  
Coramine  ·  Coramin  ·  Cordiamine
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.
Piclamilast (144035-83-6)  
Piclamilast (RP 73401), is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma.
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