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Imidazoles

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ondansetron (99614-01-4, 99614-02-5)  
Zofran  ·  Ondansetron Hydrochloride  ·  GR38032F
Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also useful in gastroenteritis. It has little effect on vomiting caused by motion sickness.
Nilotinib (641571-10-0)  
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10–30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.
methimazole (60-56-0)  
Tapazole  ·  Metizol  ·  Mercazole
2-METHYLIMIDAZOLE (693-98-1)  
2-methylimidazole, silver (1+) salt  ·  2-methylimidazole hydrochloride  ·  Zn(2-methylimidazole)2
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH3C3H2N2H. It is a white or colorless solid that is highly soluble in polar organic solvents. It is a precursor to a range of drugs and is a ligand in coordination chemistry.
pilocarpine (92-13-7, 54-71-7)  
Pilocarpine Hydrochloride  ·  Ocusert  ·  Pilocarpine Nitrate
Pilocarpine is a medication used to treat increased pressure inside the eye and dry mouth. As eye drops it is used for angle closure glaucoma until surgery can be performed, ocular hypertension, open angle glaucoma, and to bring about constriction of the pupil following their dilation. Onset of effects with the drops is typically within an hour and lasts for up to a day.
imidazole (288-32-4)  
imidazolium chloride  ·  imidazole acetate  ·  imidazole sodium
Imidazole is an organic compound with the formula C3N2H4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and having non-adjacent nitrogen atoms.
ACADESINE (2627-69-2)  
AICA riboside  ·  AICA ribonucleoside  ·  ARA-100
Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery.
Carbimazole (22232-54-8)  
Herbrand Brand of Carbimazole  ·  Neo Tomizol  ·  Sanofi Synthelabo Brand of Carbimazole
Carbimazole is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).
1-methylimidazole (616-47-7)  
1-methylimidazolium hydrogen sulfate  ·  1-methylimidazolium ethanoate  ·  N-methylimidazole
1-Methylimidazole or N-methylimidazole is an aromatic heterocyclic organic compound with the formula CH3C3H3N2. It is a colourless liquid that is used as a specialty solvent, a base, and as a precursor to some ionic liquids. It is a fundamental nitrogen heterocycle and as such mimics for various nucleoside bases as well as histidine and histamine,
Tipifarnib (192185-68-5, 192185-72-1)  
Tipifarnib (INN, proposed trade name Zarnestra) is a farnesyltransferase inhibitor that is being investigated in patients 65 years of age and older with newly diagnosed acute myeloid leukemia (AML). It inhibits the Ras kinase in a post-translational modification step before the kinase pathway becomes hyperactive. It inhibits prenylation of the CaaX tail motif, which allows Ras to bind to the membrane where it is active.
Capravirine (178979-85-6)  
AG-1549
Capravirine was a non-nucleoside reverse transcriptase inhibitor which reached phase II trials before development was discontinued by Pfizer. Both phase IIb trials which were conducted failed to demonstrate that therapy with capravirine provided any significant advantage over existing triple-drug HIV therapies, and pharmacology studies showed that capravirine may interact with other HIV drugs.
Faicar (13018-54-7)  
5-Formamidoimidazole-4-carboxamide ribotide (or FAICAR) is an intermediate in the formation of purines. It is formed by the enzyme AICAR transformylase from AICAR and 10-formyltetrahydrofolate.
beta-Pilocarpine (531-35-1, 5984-94-1)  
Pilocarpine  ·  Pilocarpine Hydrochloride  ·  Ocusert
4-Methylhistamine (36507-31-0)  
4-Methylhistamine is a histamine agonist selective for the H4 subtype.
Liarozole (115575-11-6)  
Liarozole is a retinoic acid metabolism-blocking drug and aromatase inhibitor.
DAZOXIBEN (103735-00-8, 78218-09-4)  
Dazoxiben is an orally active thromboxane synthase inhibitor. It has shown a significant clinical improvement in patients with Raynaud's syndrome.
Azalanstat (143393-27-5)  
Azalanstat (INN, codenamed RS-21607) is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor.
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