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Kappa agonists, Cyclic compounds, Neurotoxins

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Analgesics (2)
Convulsants (2)
Drugs acting on the nervous system (2)
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Antiarrhythmic agents (1)
Cycloalkanes (1)
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Delta-opioid agonists (1)
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Four-membered rings (1)
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Mu-opioid agonists (1)
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meperidine (57-42-1)  
Demerol  ·  Dolin  ·  Pethidine
Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class. Synthesized in 1939 as a potential anticholinergic agent by the German chemist Otto Eisleb, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, Germany. Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines (piminodine, anileridine and others), the prodines (alphaprodine, MPPP, etc.), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues.
Xorphanol (77287-89-9)  
Xorphanol (INN) (developmental code name TR-5379 or TR-5379M), also known as xorphanol mesylate (USAN), is an opioid analgesic of the morphinan family that was never marketed. Xorphanol is a mixed agonist–antagonist of opioid receptors, acting preferentially as a high-efficacy partial agonist/near-full agonist of the κ-opioid receptor (Ki = 0.4 nM; EC50 = 3.3 nM; Imax = 49%; IA = 0.84) and to a lesser extent as a partial agonist of the μ-opioid receptor (Ki = 0.25 nM; IC50 = 3.4 nM; Imax = 29%) with lower relative intrinsic activity and marked antagonistic potential (including the ability to antagonize morphine-induced effects and induce opioid withdrawal in opioid-dependent individuals). The drug has also been found to act as an agonist of the δ-opioid receptor (Ki = 1.0 nM; IC50 = 8 nM; Imax = 76%).

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(+/-)-Epibatidine (140111-52-0)  
Epibatidine is a putative alkaloid that is secreted by the Ecuadoran frog Epipedobates anthonyi. It was discovered by John W. Daly in 1974, but its structure was not fully elucidated until 1992.
3-Apmpa (127729-35-5)  
SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABAB receptor agonist. It has sedative effects in animal studies and is widely used in research into potential treatment of various types of drug addiction.
Mesulergine (64795-35-3)  
Mesulergine is a psychoactive drug of the ergoline chemical class that acts on serotonin and dopamine receptors. The compound had entered clinical trials for the treatment of Parkinson's disease; however, further development was halted due to adverse histological abnormalities in rats.
N-Phenylnicotinamide (1752-96-1)  
nicotinanilide  ·  nicotinanilide monohydrochloride
(Benzoylmethylene)triphenylphosphorane (859-65-4)  
SK and F 45349  ·  SKF-45349  ·  SKF 45349
2-Phenylpropylamine (582-22-9)  
beta-methylphenethylamine  ·  beta-methylphenylethylamine  ·  BMPEA compound
β-Methylphenethylamine (β-Me-PEA, BMPEA), or 1-amino-2-phenylpropane, is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. In appearance, it is a colorless or yellowish liquid.
N-(pyridin-4-yl)benzamide (5221-44-3)  
N-(4-pyridyl)benzamide
Metofoline (14415-95-3, 180003-15-0, 2154-02-1)  
Metofoline ([[International nonproprietary name|INN), also known as methofoline (USAN), is an opioid analgesic drug discovered in the 1950s by a team of Swiss researchers at Hoffmann-La Roche. Methopholine is an isoquinoline derivative which is not structurally related to most other opioids. However, its structural similarity to papaverine is notable.
Propargylamine (2450-71-7)  
propargylamine monohydrochloride  ·  propinylamine
EXIFONE (52479-85-3, 72841-23-7)  
hexahydro-2,3,4,3',4',5'-benzophenone  ·  Adlone
MUSCARINE (300-54-9)  
Muscarine, L-(+)-muscarine, or muscarin is a natural product found in certain mushrooms, particularly in Inocybe and Clitocybe species, such as the deadly C. dealbata. Mushrooms in the genera Entoloma and Mycena have also been found to contain levels of muscarine which can be dangerous if ingested. Muscarine has been found in harmless trace amounts in Boletus, Hygrocybe, Lactarius and Russula.
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