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Kappa agonists, Cyclic compounds, www.tcichemicals.com, Drugs acting on the nervous system

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Alkaloid (1)
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Heterocyclic compounds (4 or more rings) (1)
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Matrine (519-02-8)  
Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism. Matrine possesses strong antitumor activities in vitro and in vivo.

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Melatonin (8041-44-9, 73-31-4)  
Melatonin, also known as N-acetyl-5-methoxy tryptamine, is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness. Melatonin is also produced in plants where it functions as a first line of defense against oxidative stress. In animals, melatonin is involved in the entrainment (synchronization) of the circadian rhythms including sleep-wake timing, blood pressure regulation, seasonal reproduction, and many others.
15532-75-9 (15532-75-9)  
TFMPP  ·  1-(m-trifluoromethylphenyl)piperazine  ·  1-(3-trifluoromethylphenyl)piperazine
3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class. Usually in combination with its analogue benzylpiperazine (BZP), it is sold as an alternative to the illicit drug MDMA ("Ecstasy") under the name "Legal X".
5-METHOXYTRYPTAMINE (608-07-1)  
Methoxytryptamine  ·  Meksamine  ·  Mexamine
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacetylation of melatonin in the pineal gland.
2,4-THIAZOLIDINEDIONE (2295-31-0)  
thiazolidinedione  ·  T-174  ·  2,4-thiazolidinedione potassium
The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s.
Compound VII (98033-68-2)  
WIN 53338  ·  WIN-53338  ·  WIN53338
EXIFONE (52479-85-3, 72841-23-7)  
hexahydro-2,3,4,3',4',5'-benzophenone  ·  Adlone
histamine (51-45-6)  
Histamine Dihydrochloride  ·  Histamine Hydrochloride  ·  Peremin
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.
N-Phenylnicotinamide (1752-96-1)  
nicotinanilide  ·  nicotinanilide monohydrochloride
4-Hydroxyquinazoline (491-36-1)  
4(3H)-quinazolinone  ·  quinazolin-4-one
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Kappa agonists
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