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Kappa agonists, Cycloalkanes


Analgesics (4)
Cyclic compounds (4)
Drugs acting on the nervous system (4)
Opioid receptor ligands (4)
Opioids (4)
Psychoactive drugs (4)
Cyclobutanes (3)
Four-membered rings (3)
Delta-opioid agonists (2)
Dissociative drugs (2)
Pharmaceuticals (2)
Semisynthetic opioids (2)
Synthetic opioids (2)
Alcohols (1)
Analgesic (1)
Convulsants (1)
Cyclopropanes (1)
Ethers (1)
Nervous system drug (1)
Neurotoxins (1)
Three-membered rings (1)

butorphanol (42408-82-2, 58786-99-5)  
Stadol  ·  Butorphanol Tartrate  ·  Stadol NS
Butorphanol (BC 2627) is a morphinan-type synthetic agonist–antagonist opioid analgesic developed by Bristol-Myers. Brand name Stadol was recently discontinued by the manufacturer. It is now only available in its generic formulations, manufactured by Novex, Mylan, Apotex and Ben Venue Laboratories.
nalbuphine (20594-83-6)  
Nubain  ·  Nalbuphine Hydrochloride  ·  EN-2234A
Nalbuphine is a semi-synthetic opioid agonist-antagonist used commercially as an analgesic under a variety of trade names, including Nubain and Manfine.
CYCLORPHAN (4163-15-9)  
Cyclorphan is an opioid analgesic of the morphinan family that was never marketed. It acts as a μ-opioid receptor (MOR) weak partial agonist or antagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR). The drug was first synthesized in 1964 by scientists at Research Corporation.
Xorphanol (77287-89-9)  
Xorphanol (INN) (developmental code name TR-5379 or TR-5379M), also known as xorphanol mesylate (USAN), is an opioid analgesic of the morphinan family that was never marketed. Xorphanol is a mixed agonist–antagonist of opioid receptors, acting preferentially as a high-efficacy partial agonist/near-full agonist of the κ-opioid receptor (Ki = 0.4 nM; EC50 = 3.3 nM; Imax = 49%; IA = 0.84) and to a lesser extent as a partial agonist of the μ-opioid receptor (Ki = 0.25 nM; IC50 = 3.4 nM; Imax = 29%) with lower relative intrinsic activity and marked antagonistic potential (including the ability to antagonize morphine-induced effects and induce opioid withdrawal in opioid-dependent individuals). The drug has also been found to act as an agonist of the δ-opioid receptor (Ki = 1.0 nM; IC50 = 8 nM; Imax = 76%).

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1-HEXENE (592-41-6, 68526-99-8, 68783-15-3)  
1-Hexene (also Hex-1-ene) is an organic compound with the formula C6H12. It is an alkene that is classified in industry as higher olefin and an alpha-olefin, the latter term meaning that the double bond is located at the alpha (primary) position, endowing the compound with higher reactivity and thus useful chemical properties. 1-Hexene is an industrially significant linear alpha olefin.
Azacyclonol (115-46-8)  
azacyclonol hydrochloride
Azacyclonol (trade names Ataractan, Calmeran, Frenoton, Frenquel, Psychosan), also known as γ-pipradrol, is a drug which is an ataractive; an agent which diminishes hallucinations in psychotic individuals. It has also been called a tranquilizer and antipsychotic, though these definitions are not accurate as it does not actually possess such properties. Despite being a positional isomer of pipradrol, it is not a psychostimulant, and instead has mild depressant effects.
1-NONENE (124-11-8, 68855-57-2, 31387-92-5, 68526-55-6)  
Nonene is an alkene with the molecular formula C9H18. Many structural isomers are possible, depending on the location of the C=C double bond and the branching of the other parts of the molecule. Industrially, the most important nonenes are trimers of propene.
1,2,3,4-Tetrahydronaphthalene (68412-24-8, 119-64-2)  
Tetralin (1,2,3,4-tetrahydronaphthalene) is a hydrocarbon having the chemical formula C10H12. This molecule is similar to the naphthalene chemical structure except that one ring is saturated.
INDAN (496-11-7, 56573-11-6)  
Vinzons, officially the Municipality of Vinzons, is a 3rd class municipality in the province of Camarines Norte, Philippines. According to the 2015 census, it has a population of 43,485 people. The Calaguas Islands are part of Vinzons.
CYCLOHEXANOL (108-93-0)  
Anol, also known as para-hydroxypropenylbenzene, is a simple phenol that was derived via demethylation from anethole, an estrogenic constituent of anise and fennel, by Sir Charles Dodds in 1937. It was reported to possess extremely potent estrogenic activity on par with that of steroidal estrogens like estrone, with a dose of 1 μg inducing estrus in rats. However, subsequent studies with different preparations of anol failed to confirm these findings, and it was found that dimerization of anol into dianol and hexestrol can rapidly occur and that the latter impurity was responsible for the highly potent estrogenic effects.
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