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Kappa agonists, Cyclobutanes

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Analgesics (3)
Cyclic compounds (3)
Cycloalkanes (3)
Drugs acting on the nervous system (3)
Four-membered rings (3)
Opioid receptor ligands (3)
Opioids (3)
Psychoactive drugs (3)
Pharmaceuticals (2)
Semisynthetic opioids (2)
Alcohols (1)
Analgesic (1)
Convulsants (1)
Delta-opioid agonists (1)
Dissociative drugs (1)
Ethers (1)
Neurotoxins (1)
Synthetic opioids (1)

butorphanol (42408-82-2, 58786-99-5)  
Stadol  ·  Butorphanol Tartrate  ·  Stadol NS
Butorphanol (BC 2627) is a morphinan-type synthetic agonist–antagonist opioid analgesic developed by Bristol-Myers. Brand name Stadol was recently discontinued by the manufacturer. It is now only available in its generic formulations, manufactured by Novex, Mylan, Apotex and Ben Venue Laboratories.
nalbuphine (20594-83-6)  
Nubain  ·  Nalbuphine Hydrochloride  ·  EN-2234A
Nalbuphine is a semi-synthetic opioid agonist-antagonist used commercially as an analgesic under a variety of trade names, including Nubain and Manfine.
Xorphanol (77287-89-9)  
Xorphanol (INN) (developmental code name TR-5379 or TR-5379M), also known as xorphanol mesylate (USAN), is an opioid analgesic of the morphinan family that was never marketed. Xorphanol is a mixed agonist–antagonist of opioid receptors, acting preferentially as a high-efficacy partial agonist/near-full agonist of the κ-opioid receptor (Ki = 0.4 nM; EC50 = 3.3 nM; Imax = 49%; IA = 0.84) and to a lesser extent as a partial agonist of the μ-opioid receptor (Ki = 0.25 nM; IC50 = 3.4 nM; Imax = 29%) with lower relative intrinsic activity and marked antagonistic potential (including the ability to antagonize morphine-induced effects and induce opioid withdrawal in opioid-dependent individuals). The drug has also been found to act as an agonist of the δ-opioid receptor (Ki = 1.0 nM; IC50 = 8 nM; Imax = 76%).

Related Results:
UNII-37420PJU4M (32634-95-0)  
17-acetoxy-6-methylene-4-pregnene-3,20-dione  ·  17 alpha acetoxy-6-methylene-4-pregnene-3,20-dione  ·  VP-2
Pregneninolone (434-03-7)  
Ethisterone  ·  Anhydrohydroxyprogesterone  ·  17 alpha Ethynyltestosterone
Aethisteron (434-03-7)  
Ethisterone  ·  Pregneninolone  ·  Anhydrohydroxyprogesterone
17-Hydroxypregnenolone (387-79-1)  
Hydroxypregnenolone  ·  17-Hydroxypregnenolone, (3beta,13alpha,17alpha)-Isomer  ·  17-Hydroxypregnenolone, (3alpha)-Isomer
17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase (CYP17A1) that is present in the adrenal and gonads. Peak levels are reached in humans at the end of puberty and then decline.
SPIRADOLINE (87151-85-7)  
Spiradoline (U-62066) is a drug which acts as a highly selective κ-opioid agonist. It has analgesic, diuretic and antitussive effects, and produces subjective effects in animals similar to those of ketazocine and alazocine. The main effect in humans is sedation, along with analgesic and diuretic effects, but significant side effects such as dysphoria and hallucinations have stopped it from being used clinically.
Skf 83566 (94344-79-3, 99295-33-7)  
SK and F-83566  ·  1H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-  ·  7-bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
ciglitazone (74772-77-3)  
5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione  ·  ADD-3878  ·  ciglitizone
Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones.
spiperone (749-02-0)  
Spiroperidol  ·  Spiroperone
Spiperone (Spiroperidol; brand name: Spiropitan (JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use in Japan as a treatment for schizophrenia. Additionally, spiperone was identified by compound screening to be an activator of Ca2+ activated Cl− channels (CaCCs), thus a potential target for therapy of cystic fibrosis.
ALPHA-PHELLANDRENE (4221-98-1, 1329-99-3, 99-83-2, 34448-33-4)  
alpha phellandrene, (S+)-isomer  ·  alpha phellandrene, (R)-isomer  ·  5-isopropyl-2-methyl-1,3-cyclohexadiene
Phellandrene is the name for a pair of organic compounds that have a similar molecular structure and similar chemical properties. α-Phellandrene and β-phellandrene are cyclic monoterpenes and are double-bond isomers. In α-phellandrene, both double bonds are endocyclic and in β-phellandrene, one of them is exocyclic.
3,20-Allopregnanedione (566-65-4)  
5alpha-Pregnane-3,20-dione  ·  3,20-Allopregnanedione, (5beta,13alpha,17alpha)-Isomer  ·  5 alpha-Pregnane-3,20-dione
QUINPIROLE (74196-92-2, 80373-22-4)  
Quinpirole is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist. It is used in scientific research. Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it.
1077-27-6 (1077-27-6, 62-46-4)  
Lipoic Acid  ·  alpha Lipoic Acid  ·  Thioctic Acid
Skf-81297 (71636-61-8)  
SKF 81297  ·  SK and F 81297  ·  SK and F-81297
SKF-81,297 is a synthetic drug of the benzazepine chemical class that acts as a selective dopamine D1/D5 receptor full agonist, and produces a characteristic stimulant-like pattern of anorexia, hyperactivity and self-administration in animals. This profile is shared with several related drugs such as 6-Br-APB and SKF-82,958, but not with certain other D1 full agonists such as A-77,636, reflecting functional selectivity of D1 activation. Newer findings reveal that SKF-81,297 additionally acts as a partial agonist at D1-D2 receptor heteromers.
Ro 48-8071 (161582-11-2)  
Ro 48-8071hydrochloride  ·  (4'-(6-allylmethylaminohexyloxy)-2'-fluorophenyl)-4-(4-bromophenyl)methanone fumarate  ·  Ro-48-8071
Related searches
Kappa agonists
Cyclobutanes
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