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Kappa agonists, Cyclohexenes, Dissociative drugs

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Alkenes (1)
Allyl compounds (1)
Analgesics (1)
Cyclic compounds (1)
Cycloalkenes (1)
Drugs acting on the nervous system (1)
Opioid antagonists (1)
Opioid receptor ligands (1)
Opioids (1)
Pharmaceuticals (1)
Psychoactive drugs (1)
Semisynthetic opioids (1)
Six-membered rings (1)

Nalorphine (62-67-9)  
Allylnormorphine  ·  Nalorphine Hydrochloride  ·  Lethidrone
Nalorphine (INN) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonist–antagonist with opioid antagonist and analgesic properties. It was introduced in 1954 and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence. It acts at two opioid receptors — the μ-opioid receptor (MOR) where it has antagonistic effects, and at the κ-opioid receptor (KOR) (Ki = 1.6 nM; EC50 = 483 nM; Emax = 95%) where it exerts high-efficacy partial agonist/near-full agonist characteristics.

Related Results:
15532-75-9 (15532-75-9)  
TFMPP  ·  1-(m-trifluoromethylphenyl)piperazine  ·  1-(3-trifluoromethylphenyl)piperazine
3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class. Usually in combination with its analogue benzylpiperazine (BZP), it is sold as an alternative to the illicit drug MDMA ("Ecstasy") under the name "Legal X".
Ro 48-8071 (161582-11-2)  
Ro 48-8071hydrochloride  ·  (4'-(6-allylmethylaminohexyloxy)-2'-fluorophenyl)-4-(4-bromophenyl)methanone fumarate  ·  Ro-48-8071
Flavaspidic acid (114-42-1)  
Flavaspidic acid BB is a phloroglucinol derivative found in the fern Dryopteris abbreviata.
3,20-Allopregnanedione (566-65-4)  
5alpha-Pregnane-3,20-dione  ·  3,20-Allopregnanedione, (5beta,13alpha,17alpha)-Isomer  ·  5 alpha-Pregnane-3,20-dione
Fluanisone (1480-19-9)  
fluanisone dihydrochloride  ·  haloanisone  ·  fluanisone monohydrochloride
Fluanisone is a typical antipsychotic and sedative of the butyrophenone chemical class. It is used in the treatment of schizophrenia and mania. It is also a component (along with fentanyl) of the injectable veterinary formulation Hypnorm where it is used for rodent analgesia during short surgical procedures.
Nikethamide (59-26-7)  
Coramine  ·  Coramin  ·  Cordiamine
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.
spiperone (749-02-0)  
Spiroperidol  ·  Spiroperone
Spiperone (Spiroperidol; brand name: Spiropitan (JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use in Japan as a treatment for schizophrenia. Additionally, spiperone was identified by compound screening to be an activator of Ca2+ activated Cl− channels (CaCCs), thus a potential target for therapy of cystic fibrosis.
ALPHA-PHELLANDRENE (4221-98-1, 1329-99-3, 99-83-2, 34448-33-4)  
alpha phellandrene, (S+)-isomer  ·  alpha phellandrene, (R)-isomer  ·  5-isopropyl-2-methyl-1,3-cyclohexadiene
Phellandrene is the name for a pair of organic compounds that have a similar molecular structure and similar chemical properties. α-Phellandrene and β-phellandrene are cyclic monoterpenes and are double-bond isomers. In α-phellandrene, both double bonds are endocyclic and in β-phellandrene, one of them is exocyclic.
1022-13-5 (1022-13-5)  
2-MACB  ·  2-methylamino-5-chlorobenzophenone  ·  2-(N-methylamino)-5-chlorobenzophenone
TENOCYCLIDINE (21500-98-1, 1867-65-8)  
Tenocyclidine (TCP) was discovered by a team at Parke Davis in the late 1950s. It is a dissociative anesthetic drug with psychostimulant and hallucinogenic effects. It is similar in effects to phencyclidine (PCP) but is considerably more potent.
Spiroxatrine (1054-88-2)  
Spiroxatrine is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamine antagonist effects.
Pecazine (60-89-9)  
mepazine  ·  mepazine monohydrochloride  ·  pecazin
Gepirone (83928-76-1)  
Gepirone is an antidepressant and anxiolytic drug of the azapirone group that was synthesized by Bristol-Myers Squibb in 1986 and has been under development for the treatment of depression but has yet to be marketed. It has been under development in the U.S. in an extended release form (referred to as gepirone ER), but despite completing phase III clinical trials and demonstrating efficacy, it has been rejected multiple times by the Food and Drug Administration (FDA) during the drug approval process.
TRIOXIFENE (63619-84-1)  
Trioxifene (INN) (developmental code name LY-133,314), or as the salt trioxifene mesylate (USAN), is a selective estrogen receptor modulator (SERM) with competitive binding activity against estradiol for the ERα and antagonistic activity against ERα-mediated gene expression, that was under preclinical and clinical development by Eli Lilly and Company for breast cancer and prostate cancer, but was abandoned.
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Kappa agonists
Cyclohexenes
Dissociative drugs
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