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Kappa agonists, Cyclohexenes, Pharmaceuticals

Categories

Alkenes (1)
Allyl compounds (1)
Analgesics (1)
Cyclic compounds (1)
Cycloalkenes (1)
Dissociative drugs (1)
Drugs acting on the nervous system (1)
Opioid antagonists (1)
Opioid receptor ligands (1)
Opioids (1)
Psychoactive drugs (1)
Semisynthetic opioids (1)
Six-membered rings (1)

Nalorphine (62-67-9)  
Allylnormorphine  ·  Nalorphine Hydrochloride  ·  Lethidrone
Nalorphine (INN) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonist–antagonist with opioid antagonist and analgesic properties. It was introduced in 1954 and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence. It acts at two opioid receptors — the μ-opioid receptor (MOR) where it has antagonistic effects, and at the κ-opioid receptor (KOR) (Ki = 1.6 nM; EC50 = 483 nM; Emax = 95%) where it exerts high-efficacy partial agonist/near-full agonist characteristics.

Related Results:
16673-34-0 (16673-34-0)  
5-chloro-2-methoxy-N-(2-(4-sulfamoylphenyl)ethyl)benzamide
1022-13-5 (1022-13-5)  
2-MACB  ·  2-methylamino-5-chlorobenzophenone  ·  2-(N-methylamino)-5-chlorobenzophenone
2,4-THIAZOLIDINEDIONE (2295-31-0)  
thiazolidinedione  ·  T-174  ·  2,4-thiazolidinedione potassium
The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s.
ALPHA-PHELLANDRENE (4221-98-1, 1329-99-3, 99-83-2, 34448-33-4)  
alpha phellandrene, (S+)-isomer  ·  alpha phellandrene, (R)-isomer  ·  5-isopropyl-2-methyl-1,3-cyclohexadiene
Phellandrene is the name for a pair of organic compounds that have a similar molecular structure and similar chemical properties. α-Phellandrene and β-phellandrene are cyclic monoterpenes and are double-bond isomers. In α-phellandrene, both double bonds are endocyclic and in β-phellandrene, one of them is exocyclic.
Ro 48-8071 (161582-11-2)  
Ro 48-8071hydrochloride  ·  (4'-(6-allylmethylaminohexyloxy)-2'-fluorophenyl)-4-(4-bromophenyl)methanone fumarate  ·  Ro-48-8071
althiazide (133585-76-9, 5588-16-9, 133562-97-7)  
altozide  ·  altizide  ·  3-((allylthio)methyl)-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
Altizide is a thiazide diuretic. In combination with spironolactone it is sold under the brand name of Aldactacine and Aldactazine by Pfizer and other names by other companies.
Nikethamide (59-26-7)  
Coramine  ·  Coramin  ·  Cordiamine
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.
Levmetamfetamine (33817-09-3)  
Levomethamphetamine is the levorotary (L-enantiomer) form of methamphetamine. Levomethamphetamine is a sympathomimetic vasoconstrictor which is the active ingredient in some over-the-counter (OTC) nasal decongestant inhalers in the United States.
GAMMA-TERPINENE (99-85-4)  
alpha-terpinene  ·  beta-terpinene  ·  1,4-p-menthadiene
The terpinenes are a group of isomeric hydrocarbons that are classified as terpenes. They each have the same molecular formula and carbon framework, but they differ in the position of carbon-carbon double bonds. α-Terpinene has been isolated from cardamom and marjoram oils, and from other natural sources.
Pravadoline (92623-83-1)  
Pravadoline (WIN 48,098) is an antiinflammatory and analgesic drug with an IC50 of 4.9 µM and a Ki of 2511 nM at CB1, related in structure to nonsteroidal anti-inflammtory drugs (NSAIDs) such as indometacin. It was developed in the 1980s as a new antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). However, pravadoline was found to exhibit unexpectedly strong analgesic effects, which appeared at doses ten times smaller than the effective anti-inflammatory dose and so could not be explained by its action as a COX inhibitor.
1-(4-Chlorobenzhydryl)piperazine (303-26-4)  
norchlorcyclizine  ·  norchlorcyclizine hydrochloride  ·  N-(p-chlorobenzhydryl)piperazine
androsterone (53-41-8)  
Epiandrosterone  ·  5 alpha Androstan 3 alpha ol 17 one  ·  5 alpha-Androstan-3 alpha-ol-17-one
Androsterone, or 5α-androstan-3α-ol-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7 that of testosterone. Androsterone is a metabolite of testosterone and dihydrotestosterone (DHT).
2-METHYLPIPERIDINE (109-05-7)  
2-methylpiperidine hydrochloride  ·  2-pipecoline  ·  2-methylpiperidine, (+-)-isomer
Ciprofibrate (52214-84-3)  
Lipanor  ·  Oroxadin  ·  Hyperlipen
Ciprofibrate is a fibrate that was developed as a lipid-lowering agent.
Dicyandiamide (461-58-5)  
cyanoguanidine  ·  dicyandiamido sulfate  ·  dicyandiamido
2-Cyanoguanidine is a nitrile derived from guanidine. It is a dimer of cyanamide, from which it can be prepared. 2-Cyanoguanidine is a colourless solid that is soluble in water, acetone, and alcohol, but not nonpolar organic solvents.
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Kappa agonists
Cyclohexenes
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