877-202-0205     support@chemchart.com     @chemchart
        
Sign In    Register
   Reset Filters

Kappa agonists, Opioid receptor ligands, Drugs acting on the nervous system, Allyl compounds, Six-membered rings, Dissociative drugs, Opioids

Categories

Alkenes (1)
Analgesics (1)
Cyclic compounds (1)
Cycloalkenes (1)
Cyclohexenes (1)
Opioid antagonists (1)
Pharmaceuticals (1)
Psychoactive drugs (1)
Semisynthetic opioids (1)

Nalorphine (62-67-9)  
Allylnormorphine  ·  Nalorphine Hydrochloride  ·  Lethidrone
Nalorphine (INN) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonist–antagonist with opioid antagonist and analgesic properties. It was introduced in 1954 and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence. It acts at two opioid receptors — the μ-opioid receptor (MOR) where it has antagonistic effects, and at the κ-opioid receptor (KOR) (Ki = 1.6 nM; EC50 = 483 nM; Emax = 95%) where it exerts high-efficacy partial agonist/near-full agonist characteristics.
Related searches
Kappa agonists
Opioid receptor ligands
Drugs acting on the nervous system
Allyl compounds
Six-membered rings
Dissociative drugs
Opioids