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Kappa agonists, Opioid receptor ligands, Drugs acting on the nervous system, Aromatic compounds

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Analgesics (3)
Cyclic compounds (3)
Opioids (3)
Psychoactive drugs (3)
Analgesic (2)
Benzodiazepines (2)
Five-membered rings (2)
Fluoroarenes (2)
Chloroarenes (1)
Dissociative drugs (1)
Piperazines (1)
Pyrrolidines (1)
Six-membered rings (1)
Synthetic opioids (1)
Thiophenes (1)

Tifluadom (83386-35-0)  
KC 5103  ·  KC 5911  ·  KC-5911
Tifluadom is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, tifluadom has no activity at the GABAA receptor, but instead is a selective agonist for the κ-opioid receptor. In accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite.
GR-89696 (126766-32-3)  
GR 85571  ·  GR103545  ·  GR 103545
GR-89696 is a drug which acts as a highly selective κ-opioid agonist. It shows selective effects in different animal models and it is thought it may be a subtype-selective agonist for the κ2 subtype. Recent studies have suggested that GR-89696 and related κ2-selective agonists may be useful for preventing the itching which is a common side effect of conventional opioid analgesic drugs, without the additional side effects of non-selective kappa agonists.
Lufuradom (85118-42-9, 94006-14-1)  
Lufuradom (INN) is a drug and benzodiazepine derivative which, unlike other benzodiazepines, is described as an analgesic. Similarly to its analogue tifluadom, it was never marketed.
Related searches
Kappa agonists
Opioid receptor ligands
Drugs acting on the nervous system
Aromatic compounds