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Kappa agonists, Opioids, Natural opium alkaloids

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Analgesics (2)
Drugs acting on the nervous system (2)
Ethers (2)
Euphoriants (2)
Morphine (2)
Mu-opioid agonists (2)
Opiates (2)
Opioid receptor ligands (2)
Opium (2)
Psychoactive drugs (2)
Pharmaceuticals (1)

morphine (64-31-3, 57-27-2)  
Morphia  ·  Morphine Sulfate  ·  MS Contin
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals. It acts directly on the central nervous system (CNS) to decrease the feeling of pain. It can be taken for both acute pain and chronic pain.

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Synephrine (94-07-5)  
Synephrin  ·  Oxedrine  ·  Sympaethamin
Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine. p-Synephrine (or formerly Sympatol and oxedrine [BAN]) and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine. This substance is present at very low concentrations in common foodstuffs such as orange juice and other orange (Citrus species) products, both of the "sweet" and "bitter" variety.
DL-Methamphetamine (4846-07-5, 7632-10-2, 51-57-0)  
Methamphetamine  ·  Desoxyn  ·  Methylamphetamine
Methamphetamine (contracted from N-methylamphetamine) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms.
Dronabinol (308064-99-5, 6465-30-1, 1972-08-3)  
Tetrahydrocannabinol (THC) is a psychotropic cannabinoid (dronabinol, trade names Marinol and Syndros are a synthetic form of THC, approved by the FDA) and is the principal psychoactive constituent of cannabis. Its chemical name is (−)-trans-Δ⁹-tetrahydrocannabinol, and the term THC is used to refer to isomers as well. The pharmaceutical formulation dronabinol is available by prescription in the US, Canada, Germany, and New Zealand.
ISOQUINOLINE (119-65-3)  
isoquinoline hydrochloride  ·  isoquinoline conjugate acid  ·  isoquinoline hydrobromide
Isoquinoline is a heterocyclic aromatic organic compound. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring.
Cathinone (71031-15-7)  
Cathinone (also known as benzoylethanamine, or β-keto-amphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines. It is probably the main contributor to the stimulant effect of Catha edulis. Cathinone differs from many other amphetamines in that it has a ketone functional group.
cannabinol (521-35-7)  
Cannabinol (CBN) is a non-psychoactive cannabinoid found only in trace amounts in Cannabis, and is mostly found in aged Cannabis. Pharmacologically relevant quantities are formed as a metabolite of tetrahydrocannabinol (THC). CBN acts as a partial agonist at the CB1 receptors, but has a higher affinity to CB2 receptors; however, it has lower affinities relative to THC.
Oripavine (467-04-9)  
O(3)-dimethylthebaine  ·  6-demethoxythebaine  ·  oripavine hydrochloride, (5alpha)-isomer
Oripavine is an opiate and the major metabolite of thebaine. It is the parent compound from which a series of semi-synthetic opioids are derived, which includes the compounds etorphine and buprenorphine. Although its analgesic potency is comparable to morphine, it is not used clinically due to its severe toxicity and low therapeutic index.
Gnoscopine (6035-40-1)  
Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid from plants of the poppy family, without painkilling properties. This agent is primarily used for its antitussive (cough-suppressing) effects.
1022-13-5 (1022-13-5)  
2-MACB  ·  2-methylamino-5-chlorobenzophenone  ·  2-(N-methylamino)-5-chlorobenzophenone
AMPHETAMINE (60-15-1, 300-62-9)  
Amphetamine Sulfate  ·  Levoamphetamine  ·  Phenamine
Amphetamine (contracted from alpha-methylphenethylamine) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers, levoamphetamine and dextroamphetamine, in their pure amine forms.
Levmetamfetamine (33817-09-3)  
Levomethamphetamine is the levorotary (L-enantiomer) form of methamphetamine. Levomethamphetamine is a sympathomimetic vasoconstrictor which is the active ingredient in some over-the-counter (OTC) nasal decongestant inhalers in the United States.
METHAMPHETAMINE (51-57-0, 537-46-2)  
Desoxyn  ·  Methylamphetamine  ·  Methamphetamine Hydrochloride
Methamphetamine (contracted from N-methylamphetamine) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms.
Noscapine hydrchloride (912-60-7)  
Narcotine  ·  Noscapine  ·  Noscapine Hydrochloride
Laudanosine (1699-51-0, 2688-77-9)  
Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. Laudanosine also occurs naturally in minute amounts (0.1%) in opium, from which it was first isolated in 1871.
Norephedrine (36393-56-3, 14838-15-4, 37577-28-9, 700-65-2)  
Phenylpropanolamine  ·  Phenylpropanolamine Hydrochloride  ·  Dexatrim
Phenylpropanolamine (PPA) is a sympathomimetic agent which is used as a decongestant and appetite suppressant. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs.
noscapine (6035-40-1, 128-62-1, 912-60-7)  
Narcotine  ·  Noscapine Hydrochloride  ·  Dreluso Brand of Noscapine Hydrochloride
Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid from plants of the poppy family, without painkilling properties. This agent is primarily used for its antitussive (cough-suppressing) effects.
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Kappa agonists
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