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Neuroprotective agents

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Drugs acting on the nervous system (17)
Psychoactive drugs (9)
Analgesics (7)
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Monoamine oxidase inhibitors (5)
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Opioid receptor ligands (5)
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Six-membered rings (3)
Anxiolytics (2)
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Sulfonic acids (2)
Amines (1)
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Antimigraine drugs (1)
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GABA reuptake inhibitors (1)
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Melatonergic (1)
Melatonin (1)
Melatonin receptor agonists (1)
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Sigma Aldrich (7)
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simvastatin (79902-63-9)  
Simvastatin, marketed under the trade name Zocor among others, is a lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid (fat) levels. It is also used to decrease the risk of heart problems in those at high risk.
edaravone (89-25-8)  
3-methyl-1-phenyl-2-pyrazolin-5-one  ·  MCI-186  ·  norantipyrine
Edaravone, sold as under the brand names Radicava and Radicut, is an intravenous medication used to help with recovery following a stroke and to treat amyotrophic lateral sclerosis (ALS). The label carries a warning about the potential for hypersensitivity reactions to edaravone, and adverse effects include bruising, gait disturbances, headache, skin inflammation, eczema, problems breathing, excess sugar in urine, and fungal skin infections. The mechanism by which edaravone might be effective is unknown.
Cianidanol (154-23-4, 8001-48-7, 100786-01-4, 7295-85-4)  
Catechin  ·  Epicatechin  ·  Catechuic Acid
Catechin is a flavan-3-ol, a type of natural phenol and antioxidant. It is a plant secondary metabolite. It belongs to the group of flavan-3-ols (or simply flavanols), part of the chemical family of flavonoids.
(-)-Epicatechin (490-46-0)  
Catechin  ·  Epicatechin  ·  Catechuic Acid
Catechin is a flavan-3-ol, a type of natural phenol and antioxidant. It is a plant secondary metabolite. It belongs to the group of flavan-3-ols (or simply flavanols), part of the chemical family of flavonoids.
6-HYDROXYMELATONIN (2208-41-5)  
6-oxymelatonin
6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metabolite of the neurotransmitter melatonin. Similar to melatonin, 6-OHM is a full agonist of the MT1 and MT2 receptors. It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin.
Acamprosate calcium (77337-73-6)  
AOTA  ·  acamprosate  ·  Campral
Acamprosate, sold under the brand name Campral, is a medication used along with counselling to treat alcohol dependence. Acamprosate is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal. When used alone, acamprosate is not an effective therapy for alcoholism in most individuals; however, studies have found that acamprosate works best when used in combination with psychosocial support since it facilitates a reduction in alcohol consumption as well as full abstinence.
Homotaurine (3687-18-1)  
3-APS  ·  3-aminopropanesulfonic acid  ·  3-amino-1-propanesulfonic acid
Homotaurine (3-amino-1-propanesulfonic acid (3-APS) or tramiprosate (INN)) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. It has GABAergic activity, apparently by mimicking GABA, which is it resembles.
7,8,3'-TRIHYDROXYFLAVONE (137502-84-2)  
7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from 7,8-dihydroxyflavone (7,8-DHF). Relative to 7,8-DHF, 7,8,3'-THF is 2–3-fold more potent in vitro as a TrkB agonist. 7,3’-Dihydroxyflavone (7,3'-DHF) is also more potent than 7,8-DHF in vitro, indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity.
Tezampanel (154652-83-2)  
Tezampanel (INN, USAN) (code names LY-293,558, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant properties, the former of which may, at least in part, occur via blockade of calcium uptake into neurons. Tezampanel has a range of effects which may be useful for medicinal purposes, as well as its applications in scientific research.
Zonampanel (210245-80-0)  
Zonampanel (INN, code name YM872) is a quinoxalinedione derivative drug and competitive antagonist of the AMPA receptor which was being investigated by Yamanouchi/Astellas Pharma as a neuroprotective drug for the treatment of ischemic stroke but never completed clinical trials. In clinical trials, zonampanel produced severe side effects including hallucinations, agitation, and catatonia in patients, resulting in early termination of the trials.
Fanapanel (161605-73-8)  
Fanapanel (INN, code name ZK-200775), also known as MPQX, is a quinoxalinedione derivative drug which acts as a competitive antagonist of the AMPA receptor. It was under development by Schering AG for the treatment of cerebral ischemia associated with stroke and trauma, but clinical trials were halted for safety reasons related to possible glial cell toxicity and due to intolerable side effects such as excessive sedation, reduction in consciousness (consisting of stupor and coma), and transient neurological deterioration. The drug was also observed to produce visual alteration and impairment, including blurred vision, strongly impaired color perception, and reduced visual acuity and dark vision, side effects thought to be caused by blockade of AMPA receptors in the retina.
CI-966 (110283-79-9)  
CI-966 (developmental code name) is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective blocker of the GABA transporter 1 (GAT-1) (IC50 = 0.26 µM), and hence indirect and non-selective GABA receptor full agonist. It was investigated as a potential anticonvulsant, anxiolytic, and neuroprotective therapeutic but was discontinued during clinical development due to the incidence of severe adverse effects at higher doses and hence was never marketed. In a phase I human clinical trial while under development for the treatment of epilepsy, CI-966 was assessed at doses of 1–10 mg, 25 mg, and 50 mg.
Tolibut (28311-38-8)  
Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) (that is, a GABA analogue) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substition. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties.

Related Results:
Thymoquinone (73940-92-8, 490-91-5)  
2-methyl-5-isopropyl-p-benzoquinone  ·  2-isopropyl-5-methylbenzoquinone  ·  dihydrothymoquinone
Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It is also found in select cultivated Monarda fistulosa plants grown and steam distilled in the USA producing an essential oil. In laboratory experiments in cells and in animals, it has shown anti-inflammatory and anti-oxidant effects, and has been studied in models of cardiovascular diseases and diabetes, neurodegenerative diseases and stroke, and cancer.
Crocin (94238-00-3, 39465-00-4, 42553-65-1)  
alpha-crocin
Crocin is a carotenoid chemical compound that is found in the flowers crocus and gardenia. Crocin is the chemical primarily responsible for the color of saffron. Chemically, crocin is the diester formed from the disaccharide gentiobiose and the dicarboxylic acid crocetin.
L-Carnosine (305-84-0)  
Carnosine  ·  Carnosine Hydrochloride  ·  Carnosine, (D-His)-Isomer
Carnosine (beta-alanyl-L-histidine), featuring the characteristic Imidazole-ring, is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. Carnosine and carnitine were discovered by Russian chemist Vladimir Gulevich.
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