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PPAR agonists

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Drugs acting on the gastrointestinal system and metabolism (24)
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gemfibrozil (25812-30-0)  
Lopid  ·  Pilder  ·  CI719
Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid.
Pioglitazone (111025-46-8)  
Actos  ·  pioglitazone hydrochloride  ·  U72,107A
Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione (TZD) class with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. While pioglitazone does decrease blood sugar levels, studies on the main cardiovascular outcomes have not yielded statistically significant results. Its cardiovascular safety profile compares favorably with that of rosiglitazone, which was withdrawn from some markets after concerns about an increased risk of cardiac events.
rosiglitazone (122320-73-4)  
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.
fenofibrate (49562-28-9)  
CiL  ·  Tricor  ·  Lofibra
Fenofibrate, marketed as Tricor and under several other brand names, is a drug of the fibrate class. It is mainly used to reduce cholesterol levels in people at risk of cardiovascular disease. Like other fibrates, it reduces both low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high-density lipoprotein (HDL) levels and reducing triglyceride levels.
Telmisartan (144701-48-4)  
Telmisartan (INN) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. It was discovered by Boehringer Ingelheim and launched in 1999 as Micardis. In January 2014, Actavis as generic version of Micardis got appoval from FDA.
BISPHENOL A DIGLYCIDYL ETHER (1675-54-3, 500008-19-5)  
DGEBA  ·  DGEBPA  ·  2,2-bis(p-glycidyloxyphenyl)propane
Bisphenol A diglycidyl ether (commonly abbreviated BADGE or DGEBA) is an organic compound used as constituent of epoxy resins. The compound is a colorless solid (commercial samples can appear yellow) that melts slightly above room temperature.
clofibrate (637-07-0)  
Atromid  ·  Atromid S  ·  Ethyl Chlorophenoxyisobutyrate
Clofibrate (tradename Atromid-S) is an organic compound. It is marketed as a fibrate. It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood.
troglitazone (97322-87-7)  
Troglitazone (Rezulin, Resulin, Romozin, Noscal) is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for patients with diabetes mellitus type 2. It was developed by Daiichi Sankyo (Japan).
bezafibrate (41859-67-0)  
Cedur  ·  BM15.075  ·  Regadrin B
Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used as a lipid-lowering agent to treat hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL.
Ciprofibrate (52214-84-3)  
Lipanor  ·  Oroxadin  ·  Hyperlipen
Ciprofibrate is a fibrate that was developed as a lipid-lowering agent.
Etofibrate (31637-97-5)  
Lipo-Merz  ·  etofibrate hydrochloride  ·  Tricerol
Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and are released gradually, in a manner similar to controlled-release formulations.
Tesaglitazar (251565-85-2)  
Tesaglitazar (also known as AZ 242) is a dual peroxisome proliferator-activated receptor agonist with affinity to PPARα and PPARγ, proposed for the management of type 2 diabetes. The drug had completed several phase III clinical trials, however in May, 2006 AstraZeneca announced that it had discontinued further development.
ciglitazone (74772-77-3)  
5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione  ·  ADD-3878  ·  ciglitizone
Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones.
Muraglitazar (331741-94-7)  
Muraglitazar (proposed tradename Pargluva) is a dual peroxisome proliferator-activated receptor agonist with affinity to PPARα and PPARγ. The drug had completed phase III clinical trials, however in May, 2006 Bristol-Myers Squibb announced that it had discontinued further development. Data on muraglitazar is relatively sparse due to the recent introduction of this agent.
Tetradecylthioacetic acid (2921-20-2)  
Tetradecylthioacetic acid (TTA) is a synthetic fatty acid used as a nutritional supplement. TTA acts as a peroxisome proliferator-activated receptor alpha (PPARα) agonist and increases mitochondrial fatty acid oxidation in vitro. In rodent studies, TTA has been reported to have other activities such as reducing inflammation and preventing high fat diet induced adiposity and insulin resistance.
Farglitazar (196808-45-4)  
Farglitazar is a peroxisome proliferator-activated receptor agonist which is being developed by GlaxoSmithKline for the treatment of hepatic fibrosis. It is currently in phase II clinical trials.
Netoglitazone (161600-01-7)  
Netoglitazone (also called MCC-555) is a hypoglycemic agent belonging to the thiazolidinedione group.
simfibrate (14929-11-4)  
Cholesolvin  ·  CLY-503  ·  1,3-propanediol bis(alpha-p-chlorophenoxyisobutyrate)
Simfibrate is a fibrate.
Clofibride (26717-47-5)  
MG 46  ·  lipenan  ·  N-dimethylbutyramide 4-chlorophenoxyisobutyrate
Clofibride is a fibrate.
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