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Polycyclic organic compounds, Cholinergics, Neurotoxins, Pharmaceuticals

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Cyclic compounds (2)
Drugs acting on the nervous system (2)
Heterocyclic compounds (2)
Heterocyclic compounds (bridged-ring) (2)
Nicotinic agonists (2)
Parasympathomimetics (2)
Psychoactive drugs (2)

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Varenicline (249296-44-4)  
Varenicline (trade name Chantix and Champix), is a prescription medication used to treat nicotine addiction. It both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. It is a high-affinity partial agonist for the α4β2 nicotinic acetylcholine receptor subtype (nACH) that leads to the release of dopamine in the nucleus accumbens when activated, and therefore, has the capacity to reduce the feelings of craving and withdrawal caused by smoking cessation.
CYTISINE (485-35-8)  
Tsitizin  ·  cytisine hydrochloride, hydrate  ·  cytisine hydrochloride
Cytisine, also known as baptitoxine and sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation. Its molecular structure has some similarity to that of nicotine and it has similar pharmacological effects.

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TASOSARTAN (145733-36-4)  
Tasosartan is an angiotensin II receptor antagonist. It was withdrawn from FDA review by the manufacturer after phase III clinical trials showed elevated transaminases (a sign of possible liver toxicity) in a significant number of participants given the drug.
Biphenyl (92-52-4, 68409-73-4)  
diphenyl  ·  diphenyl, 14C-labeled
Biphenyl (or diphenyl or phenylbenzene or 1,1′-biphenyl or lemonene) is an organic compound that forms colorless crystals. Particularly in older literature, compounds containing the functional group consisting of biphenyl less one hydrogen (the site at which it is attached) may use the prefixes xenyl or diphenylyl. It has a distinctively pleasant smell.
2-CHLORONAPHTHALENE (1321-65-9, 1335-88-2, 91-58-7)  
2-Chloronaphthalene is an organochlorine chemical compound, a chlorinated derivative of naphthalene. Its chemical formula is C 10H 7Cl. The compound is an isomer for 1-chloronaphthalene.
CHRYSENE (65996-93-2, 50-32-8, 218-01-9)  
Chrysene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C 18H 12 that consists of four fused benzene rings. It is a natural constituent of coal tar, from which it was first isolated and characterized. It is also found in creosote at levels of 0.5-6 mg/kg.
Dioxin (1746-01-6)  
TCDD  ·  PCDD  ·  Tetrachlorodibenzodioxin
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a polychlorinated dibenzo-p-dioxin (sometimes shortened, though inaccurately, to simply "dioxin") with the chemical formula C 12H 4Cl 4O 2. TCDD is a colorless solid with no distinguishable odor at room temperature. It is usually formed as a side product in organic synthesis and burning of organic materials.
2-METHYLNAPHTHALENE (7419-61-6, 91-57-6)  
2-methylnaphthalene, methyl-13C-labeled  ·  2-methylnaphthalene, lithium salt, ion(1-)  ·  2-methylnaphthalene, naphthalene-1-(13)C-labeled
2-Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH). On February 22, 2014, NASA announced a greatly upgraded database for detecting and monitoring PAHs, including 2-methylnaphthalene, in the universe. According to NASA scientists, over 20% of the carbon in the universe may be associated with PAHs, possible starting materials for the formation of life.
1-METHYLNAPHTHALENE (90-12-0, 1321-94-4)  
1-Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH). It has a cetane number of zero, and was previously used as the lower reference for cetane number. However, due to the expense and handling difficulty of 1-methylnaphthalene, it was replaced in this capacity by isocetane, with a CN of 15.
ACENAPHTHENE (83-32-9)  
Acenaphthene is a polycyclic aromatic hydrocarbon (PAH) consisting of naphthalene with an ethylene bridge connecting positions 1 and 8. It is a colourless solid. Coal tar consists of about 0.3% of this compound.
HEXACHLOROETHANE (67-72-1)  
perchloroethane  ·  carbon hexachloride  ·  Avlothane
Hexachloroethane, also known as perchloroethane (PCA), C2Cl6, is a white crystalline solid at room temperature with a camphor-like odor. It has been used by the military in smoke compositions, such as base-eject smoke munitions (smoke grenades).
FLUORENE (2299-68-5, 86-73-7)  
9H-fluorene
Fluorene , or 9H-fluorene, is a polycyclic aromatic hydrocarbon. It forms white crystals that exhibit a characteristic, aromatic odor similar to that of naphthalene. It is combustible.
1,1,1,2-TETRACHLOROETHANE (23425-39-0, 630-20-6)  
1,1,1,2-Tetrachloroethane is a chlorinated hydrocarbon. It is a colorless liquid with a sweet chloroform-like odor. It is used as a solvent and in the production of wood stains and varnishes.
naphthalene (91-20-3, 68412-25-9)  
Naphthalene is an organic compound with formula C 10H 8. It is the simplest polycyclic aromatic hydrocarbon, and is a white crystalline solid with a characteristic odor that is detectable at concentrations as low as 0.08 ppm by mass. As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings.
FLUORANTHENE (206-44-0, 76774-50-0)  
Fluoranthene is a polycyclic aromatic hydrocarbon (PAH). The molecule can be viewed as the fusion of naphthalene and benzene unit connected by a five-membered ring. Although samples are often pale yellow, the compound is colorless.
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