Polycyclic organic compounds, matrixscientific.com, Pharmaceuticals, Six-membered rings, Antineoplastic and immunomodulating drugs
Cyclic compounds (1)
Zosuquidar Trihydrochloride (167465-36-3)
Zosuquidar (also LY-335979) is an experimental antineoplastic drug. In 2010, it was announced that a phase III trial for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome did not meet its primary endpoint and Eli Lilly discontinued its development. Zosquidir inhibits P-glycoproteins.
Biphenyl (92-52-4, 68409-73-4)
diphenyl · diphenyl, 14C-labeled
Biphenyl (or diphenyl or phenylbenzene or 1,1′-biphenyl or lemonene) is an organic compound that forms colorless crystals. Particularly in older literature, compounds containing the functional group consisting of biphenyl less one hydrogen (the site at which it is attached) may use the prefixes xenyl or diphenylyl. It has a distinctively pleasant smell.
2-METHYLNAPHTHALENE (7419-61-6, 91-57-6)
2-methylnaphthalene, methyl-13C-labeled · 2-methylnaphthalene, lithium salt, ion(1-) · 2-methylnaphthalene, naphthalene-1-(13)C-labeled
2-Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH). On February 22, 2014, NASA announced a greatly upgraded database for detecting and monitoring PAHs, including 2-methylnaphthalene, in the universe. According to NASA scientists, over 20% of the carbon in the universe may be associated with PAHs, possible starting materials for the formation of life.
1-Phenyltridecane (123-02-4, 68648-87-3, 129813-59-8, 29463-64-7)
A 215 · A-215 · alkylate-215
Tasosartan is an angiotensin II receptor antagonist. It was withdrawn from FDA review by the manufacturer after phase III clinical trials showed elevated transaminases (a sign of possible liver toxicity) in a significant number of participants given the drug.
1-METHYLNAPHTHALENE (90-12-0, 1321-94-4)
1-Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH). It has a cetane number of zero, and was previously used as the lower reference for cetane number. However, due to the expense and handling difficulty of 1-methylnaphthalene, it was replaced in this capacity by isocetane, with a CN of 15.
9H-carbazole · 9-azafluorene · dibenzo(b,d)pyrrole
Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene rings fused on either side of a five-membered nitrogen-containing ring. The compound's structure is based on the indole structure, but in which a second benzene ring is fused onto the five-membered ring at the 2–3 position of indole (equivalent to the 9a–4a double bond in carbazole, respectively).
1,1,1,2-TETRACHLOROETHANE (23425-39-0, 630-20-6)
1,1,1,2-Tetrachloroethane is a chlorinated hydrocarbon. It is a colorless liquid with a sweet chloroform-like odor. It is used as a solvent and in the production of wood stains and varnishes.
1,2-DIHYDRONAPHTHALENE (447-53-0, 29828-28-2)
Dialin (1,2-dihydronaphthalene) is a hydrocarbon with the chemical formula C10H10. It is similar to naphthalene but one ring is partially saturated.
CHRYSENE (65996-93-2, 50-32-8, 218-01-9)
Chrysene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C 18H 12 that consists of four fused benzene rings. It is a natural constituent of coal tar, from which it was first isolated and characterized. It is also found in creosote at levels of 0.5-6 mg/kg.