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Potassium channel blockers


Antiarrhythmic agents (36)
Drugs acting on the cardiovascular system (36)
Cyclic compounds (18)
Pharmaceuticals (18)
Drugs acting on the nervous system (14)
Drugs acting on the gastrointestinal system and metabolism (13)
Psychoactive drugs (13)
Anti-diabetic drugs (12)
Six-membered rings (11)
Aromatic compounds (10)
Sulfonylureas (9)
Antitussives (8)
Drugs acting on the respiratory system (8)
Respiratory system drug (8)
Amines (7)
Bases (chemistry) (7)
Piperidines (7)
Gastrointestinal system drug (6)
Analgesics (5)
Chloroarenes (5)
Five-membered rings (5)
Opioid receptor ligands (5)
Opioids (5)
Synthetic opioids (5)
Euphoriants (4)
Mu-opioid agonists (4)
Pyridines (4)
Antihistamines (3)
Ethers (3)
H1 receptor antagonists (3)
Meglitinides (3)
Ureas (3)
Antianginals (2)
Antihypertensive agents (2)
Aromatic ketones (2)
Beta blockers (2)
Cardiovascular system drug (2)
Disulfiram-like drugs (2)
Dopamine antagonists (2)
Sodium channel blockers (2)
Acetaldehyde dehydrogenase inhibitors (1)
Alcohols (1)
Antidiuretics (1)
Antiemetics (1)
Antipsychotics (1)
Aromatic amines (1)
Cycloalkanes (1)
Cyclopentanes (1)
Cyclopropanes (1)
D2 antagonists (1)
D3 antagonists (1)
D4 antagonists (1)
Decongestants (1)
Diphenylbutylpiperidines (1)
Drugs acting on the genito-urinary system (1)
Drugs acting on the musculoskeletal system (1)
Expectorants (1)
Fluoroarenes (1)
Halides (1)
Isoxazoles (1)
Monoamine reuptake inhibitors (1)
Motility stimulants (1)
Muscle relaxants (1)
Nervous system drug (1)
Nitrobenzenes (1)
Nootropics (1)
Norepinephrine reuptake inhibitors (1)
Opioid metabolites (1)
Organobromides (1)
Organohalides (1)
Psychoanaleptics (1)
Psychopharmacology (1)
Pyrimidines (1)
Pyrrolidines (1)
Pyrrolines (1)
Quaternary ammonium compounds (1)
Quaternary compounds (1)
Systemic hormonal preparations (1)
Thiophenes (1)
Three-membered rings (1)
Typical antipsychotics (1)


Sigma Aldrich (12)
AK Scientific (9)
TCI Chemicals (6)
Frontier Scientific (4)
Matrix Scientific (4)
Apollo Scientific (2)
Oakwood Chemical (2)
SynQuest Laboratories (2)
Accela (1)
Toronto Research Chemicals (1)

4-aminopyridine (504-24-5)  
VMI103  ·  Fampridine SR  ·  Fampridine-SR
4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool in characterizing subtypes of the potassium channel.
Dextropropoxyphene (469-62-5, 2621-61-6, 2338-37-6)  
Propoxyphene  ·  Darvon  ·  Propoxyphene Hydrochloride
Dextropropoxyphene is an analgesic in the opioid category, patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anaesthetic effects.
Dofetilide (115256-11-6)  
Dofetilide is a class III antiarrhythmic agent. It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 µg of dofetilide. It is not available in Europe or Australia.
chlorpropamide (94-20-2)  
Diabinese  ·  Glucamide  ·  Clorpropamid
Chlorpropamide is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation sulfonylurea. It has more side effects than other sulfonylureas and its use is no longer recommended.
Ibutilide (122647-32-9, 122647-31-8)  
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents.
tolbutamide (64-77-7)  
Orinase  ·  Diabetol  ·  Rastinon
Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas.
acetohexamide (968-81-0)  
Dymelor  ·  Dimelor  ·  Gamadiabet
Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.
orphenadrine (83-98-7)  
Norflex  ·  Orphenadrine Citrate  ·  Disipal
Orphenadrine (sold under many brand names worldwide) is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine. It is used to treat muscle pain and to help with motor control in Parkinson's disease, but has largely been superseded by newer drugs. It was discovered and developed in the 1940s.
pimozide (2062-78-4)  
Orap  ·  Antalon  ·  Orap forte
Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1).
glimepiride (684286-46-2, 93479-97-1)  
Amaryl  ·  Amarel  ·  Aventis brand of glimepiride
Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or as second-generation.
sotalol (3930-20-9)  
Sotalol is a medication used to treat abnormal heart rhythms. The U.S. Food and Drug Administration (FDA) advises that sotalol only be used for serious abnormal heart rhythms, because its prolongation of the QT interval carries a small risk of life-threatening polymorphic ventricular tachycardia known as torsade de pointes.
Carbutamide (339-43-5)  
Glucidoral  ·  Bucarban  ·  Oranyl
Carbutamide (brand name Glucidoral) is an anti-diabetic drug of the sulfonylurea class, developed by Servier. It is classified as first-generation.
domperidone (57808-66-9)  
Motilium  ·  Apo-Domperidone  ·  Gastrocure
Domperidone, sold under the brand name Motilium among others, is a peripherally selective dopamine D2 receptor antagonist that was developed by Janssen Pharmaceutica and is used as an antiemetic, gastroprokinetic agent, and galactagogue. It may be administered orally or rectally, and is available in the form of tablets, orally disintegrating tablets (based on Zydis technology), suspension, and suppositories. The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.
Levopropoxyphene (2338-37-6)  
Levopropoxyphene is an antitussive. It is an optical isomer of dextropropoxyphene. The racemic mixture is called propoxyphene.
Mitiglinide (145375-43-5, 207844-01-7)  
Mitiglinide (INN, trade name Glufast) is a drug for the treatment of type 2 diabetes. Mitiglinide belongs to the meglitinide (glinide) class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals.
Gliquidone (33342-05-1, 62783-47-5)  
gliquidone, monosodium salt  ·  gliquidone, calcium salt  ·  Beglynora
Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class. It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2.
Glisoxepide (25046-79-1)  
Pro-diaban  ·  4-(4-beta-(5-methylisoxazol-3-carboxamidoethyl)phenylsulfonyl)-1,1-hexamethylenesemicarbazide  ·  RP-22410
Glisoxepide (INN) is an orally available anti-diabetic drug from the group of sulfonylureas. It belongs to second-generation sulfonylureas.
Bretylium (59-41-6)  
bretylium iodide  ·  bretylium bromide  ·  bretylium chloride
Bretylium (also bretylium tosylate) is an antiarrhythmic agent. It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system.
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