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Pyrazoles, www.sigmaaldrich.com, Cannabis, AM cannabinoids

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AM251 (183232-66-8)  
AM 251  ·  N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide  ·  N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group.

Related Results:
2-Amino-1-phenylethanol (4561-43-7, 7568-93-6)  
beta Phenylethanolamine  ·  2-Hydroxyphenethylamine  ·  beta-Hydroxyphenethylamine
Phenylethanolamine (sometimes abbreviated PEOH), or β-hydroxyphenethylamine, is a trace amine with a structure similar to those of other trace phenethylamines as well as the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine. As an organic compound, phenylethanolamine is a β-hydroxylated phenethylamine that is also structurally related to a number of synthetic drugs in the substituted phenethylamine class. In common with these compounds, phenylethanolamine has strong cardiovascular activity and, under the name Apophedrin, has been used as a drug to produce topical vasoconstriction.
2-Methylbenzyl alcohol (89-95-2)  
2-methylbenzyl alcohol, 3H-labeled  ·  ortho-methylbenzyl alcohol
Cyclopropylmethanol (2516-33-8)  
cyclopropylcarbinol
2-Phenyl-2-propanol (617-94-7)  
dimethylphenylcarbinol  ·  2-phenylpropanol-2
DL-Methamphetamine (4846-07-5, 7632-10-2, 51-57-0)  
Methamphetamine  ·  Desoxyn  ·  Methylamphetamine
Methamphetamine (contracted from N-methylamphetamine) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms.
TENOCYCLIDINE (21500-98-1, 1867-65-8)  
Tenocyclidine (TCP) was discovered by a team at Parke Davis in the late 1950s. It is a dissociative anesthetic drug with psychostimulant and hallucinogenic effects. It is similar in effects to phencyclidine (PCP) but is considerably more potent.
2-Phenylpropylamine (582-22-9)  
beta-methylphenethylamine  ·  beta-methylphenylethylamine  ·  BMPEA compound
β-Methylphenethylamine (β-Me-PEA, BMPEA), or 1-amino-2-phenylpropane, is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. In appearance, it is a colorless or yellowish liquid.
PROPARGYL ALCOHOL (107-19-7)  
2-propyn-1-ol  ·  propargyl alcohol, lithium salt  ·  propargyl alcohol, sodium salt
Propargyl alcohol, or 2-propyn-1-ol, is an organic compound with the formula C3H4O. It is the simplest stable alcohol containing an alkyne functional group. Propargyl alcohol is a colorless viscous liquid that is miscible with water and most polar organic solvents.
2-(Methylamino)-1-phenylethanol (6589-55-5, 68579-60-2)  
N-methylphenylethanolamine, (+-)-isomer  ·  N-methylphenylethanolamine hydrochloride  ·  MPEOA
Halostachine (also known as N-methylphenylethanolamine) is a natural product, an alkaloid first isolated from the Asian shrub Halostachys caspica (synonym Halostachys belangeriana), and structurally a β-hydroxy-phenethylamine (a phenylethanolamine) related to its better-known "parent" biogenic amine, phenylethanolamine, to the adrenergic drug synephrine, and to the alkaloid ephedrine. The pharmacological properties of halostachine have some similarity to those of these structurally-related compounds, and Halostachys caspica extracts have been included as a constituent of certain OTC dietary supplements, but halostachine has never been developed as a prescription drug. Although it is found in nature as a single stereoisomer, halostachine is more commonly available as a synthetic product in the form of its racemate (see below).
MMDA (13674-05-0)  
MMDA (3-methoxy-4,5-methylenedioxyamphetamine; 5-methoxy-MDA) is a psychedelic and entactogen drug of the amphetamine class. It is an analogue of lophophine, MDA, and MDMA. MMDA was described by Alexander Shulgin in his book PiHKAL.
Methadrene (554-99-4)  
N-methylepinephrine  ·  alpha((dimethylamino)methyl)- 3,4-dihydroxybenzyl alcohol  ·  N-methyladrenaline
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