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Synthetic estrogens

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ethinyl estradiol (57-63-6)  
Estinyl  ·  Ethinyloestradiol  ·  Ethynyl Estradiol
Ethinylestriol (EE3), or 17α-ethynylestriol, also known as 17α-ethynylestra-1,3,5(10)-triene-3,16α,17β-triol, is a synthetic, steroidal estrogen that was never marketed. Nilestriol, the 3-cyclopentyl ether of ethinylestriol, is a prodrug of ethinylestriol, and is a more potent estrogen in comparison, but, similarly to ethinylestriol, was never marketed. Ethinylestriol has been found to reduce the risk of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary cancer when given as a prophylactic in animal models, while other estrogens like ethinylestradiol and diethylstilbestrol were ineffective.
norethindrone (68-22-4)  
Norethisterone  ·  Micronor  ·  Norlutin
Norethisterone (NET), also known as norethindrone, is a medication that is used in combination with estrogen or alone in hormonal contraceptives, menopausal hormone therapy, and in the treatment of gynecological disorders. It is a synthetic progestogen (or a progestin) of the 19-nortestosterone group and has similar effects to those of natural progesterone, including suppression of gonadotropins, ovulation inhibition, and endometrial transformation. In addition to its progestogenic activity, NET also has weak androgenic and estrogenic effects at high dosages.
diethylstilbestrol (6898-97-1, 56-53-1, 22610-99-7, 64-67-5)  
Stilbestrol  ·  Distilbène  ·  Stilbene Estrogen
ethynodiol (1231-93-2)  
ethinodiol
Etynodiol, or ethynodiol, is a steroidal progestin of the 19-nortestosterone group which was never marketed. A diacylated derivative, etynodiol diacetate, is used as a hormonal contraceptive. While etynodiol is sometimes used as a synonym for etynodiol diacetate, it usually refers to etynodiol diacetate, not etynodiol.
dienestrol (35495-11-5, 84-17-3, 13029-44-2)  
Dienoestrol  ·  Ortho Dienestrol  ·  Dienestrol, (Z,E)-Isomer
Dienestrol (INN, USAN) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others), also known as dienoestrol (BAN), is a synthetic nonsteroidal estrogen of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe. It was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene.
Estrodienol (35495-11-5)  
Dienestrol (INN, USAN) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others), also known as dienoestrol (BAN), is a synthetic nonsteroidal estrogen of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe. It was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene.
LYNESTRENOL (52-76-6)  
Ethinylestrenol  ·  Linestrenol  ·  Lynestrenol, (9 beta, 10 alpha,17 alpha)-Isomer
Lynestrenol is a progestin which is used in oral contraceptives in combination with an estrogen and in the treatment of gynecological disorders. It is has potent progestogenic effects on the uterine endometrium (transforming proliferative endometrium into secretory one), inhibits secretion of gonadotropins, suppresses maturation of follicles in the ovaries and ovulation, and reduces menstrual bleeding.
chlorotrianisene (569-57-3)  
Chlorotrianisene (INN, USAN, BAN; brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, many others; also known as CTA; tri-p-anisylchloroethylene, TACE, or tris(p-methoxyphenyl)chloroethylene) is a synthetic nonsteroidal estrogen of the triphenylethylene group which was formerly used for the treatment of menopausal symptoms, estrogen deficiency, and prostate cancer before being discontinued. It was approved in the United States as TACE in 1952, and was introduced throughout Europe subsequently. CTA was the first estrogenic compound of the triphenylethylene series to be introduced.
ETHYNODIOL DIACETATE (297-76-7)  
Continuin  ·  Femulen  ·  (3 beta, 17 alpha)-19-Norpregn-4-en-20-yne-3,17 diol Diacetate
Etynodiol diacetate, or ethynodiol diacetate, is a progestin of the 19-nortestosterone group which is used in oral contraceptives. It is the 3β,17β-diacetate ester of etynodiol, and acts as a rapidly converted prodrug of norethisterone, with etynodiol occurring as an intermediate. Etynodiol diacetate has weak androgenic activity, and, unlike most progestins but similarly to norethisterone and noretynodrel, also has some estrogenic activity.
hexestrol (84-16-2, 5635-50-7)  
Hexestrol, (R-(R*,R*))-Isomer  ·  Hexestrol, (R*,S*)-Isomer  ·  Dihydrodiethylstilbestrol
Hexestrol (INN) (brand names Synestrol, Synoestrol, Estrifar, Estronal, numerous others), also known as hexanestrol, hexoestrol, and dihydrodiethylstilbestrol, is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol which was used to treat estrogen deficiency. Oil solution of hexestrol is still manufactured in Russia under trade name Синэстрол.[1] Hexestrol has also been available and used in ester form, including as hexestrol diacetate, hexestrol dicaprylate, hexestrol diphosphate, and hexestrol dipropionate. Hexestrol has approximately 302% and 234% of the affinity of estradiol at the ERα and ERβ, respectively.
meso-Hexestrol (84-16-2)  
Hexestrol  ·  Hexestrol, (R-(R*,R*))-Isomer  ·  Hexestrol, (R*,S*)-Isomer
Estradiol mustard (22966-79-6)  
Estradiol mustard (developmental code name NSC-112259), also known as chlorphenacyl estradiol diester, as well as estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic, steroidal estrogen and alkylating antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was never marketed. It is selectively distributed into estrogen receptor (ER)-positive tissues such as ER-expressing tumors like those seen in breast and prostate cancers. For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard alkylating antineoplastic agents.
fosfestrol (522-40-7)  
Stilphostrol  ·  diethylstilbestrol diphosphate  ·  Kyorin
Fosfestrol (INN, BAN, JAN) (brand names Honvan, Difostilben, Fosfostilben, Fostrolin, Stilbol, Stilphostrol, Vagestrol, among others), also known as diethylstilbestrol diphosphate (USAN), abbreviated as DESDP or DESP, is a synthetic nonsteroidal estrogen of the stilbestrol group which is or has been used in the treatment of prostate cancer. It is a prodrug of diethylstilbestrol. The drug has been marketed widely throughout the world, including in the United States, Canada, Europe, Hong Kong, and Mexico.
METHALLENESTRIL (517-18-0)  
Vallestril  ·  methallenestril, (+)-isomer  ·  methallenestril, (+-)-isomer
Methallenestril (INN) (brand names Cur-men, Ercostrol, Geklimon, Novestrine, Vallestril), also known as methallenoestril (BAN) and as methallenestrol, as well as Horeau's acid, is a synthetic nonsteroidal estrogen and a derivative of allenolic acid and allenestrol (specifically, a methyl ether of it) that was formerly used to treat menstrual issues but is now no longer marketed. It is a seco-analogue of bisdehydrodoisynolic acid, and although methallenestril is potently estrogenic in rats, in humans it is only weakly so in comparison. Vallestril was a brand of methallenestril issued by G.
16alpha-Hydroxyestrone (566-76-7)  
16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol. It is a potent estrogen similarly to estrone, and it has been suggested that the ratio of 16α-hydroxyestrone to 2-hydroxyestrone, the latter being much less estrogenic in comparison and even antiestrogenic in the presence of more potent estrogens like estradiol, may be involved in the pathophysiology of breast cancer. Conversely, 16α-hydroxyestrone may help to protect against osteoporosis.
estradiol dipropionate (113-38-2)  
estradiol dipropionate, (17alpha)-isomer
Estradiol dipropionate (BAN, JAN) (brand names Agofollin, Di-Ovocyclin, Progynon DP, others) is a semisynthetic, steroidal estrogen that is or has been marketed in the United States and Europe. It is the 3,17β-dipropanoyl ester of estradiol. Along with estradiol benzoate, estradiol dipropionate was one of the first estradiol esters to be developed, having been patented in 1937, was assessed in clinical studies by 1939, and has been marketed by Schering as Progynon DP and Ciba Pharmaceutical Products as Di-Ovocylin since at least 1940.
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