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Topoisomerase inhibitors

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Antineoplastic and immunomodulating drugs (31)
Antineoplastic drugs (31)
DNA replication inhibitors (31)
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DNA intercalaters (3)
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etoposide (33419-42-0)  
VP16  ·  Vepesid  ·  VP 16
Teniposido (29767-20-2)  
Teniposide  ·  Vumon  ·  VM26
Teniposide (trade name Vumon) is a chemotherapeutic medication used in the treatment of childhood acute lymphocytic leukemia (ALL), Hodgkin's lymphoma, certain brain tumours, and other types of cancer. It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.
teniposide (29767-20-2)  
Vumon  ·  VM26  ·  VM 26
Teniposide (trade name Vumon) is a chemotherapeutic medication used in the treatment of childhood acute lymphocytic leukemia (ALL), Hodgkin's lymphoma, certain brain tumours, and other types of cancer. It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.
Valrubicin (56124-62-0)  
Valrubicin (N-trifluoroacetyladriamycin-14-valerate, trade name Valstar) is a chemotherapy drug used to treat bladder cancer. Valrubicin is a semisynthetic analog of the anthracycline doxorubicin, and is administered by infusion directly into the bladder. It was originally launched as Valstar in the U.S.
novobiocin (303-81-1, 1476-53-5)  
Novobiocin Sodium  ·  Streptonivicin  ·  Monosodium Salt Novobiocin
nalidixic acid (389-08-2)  
Nalidixate Sodium Anhydrous  ·  Nevigramon  ·  Nalidixin
Nalidixic acid (tradenames Nevigramon, Neggram, Wintomylon and WIN 18,320) is the first of the synthetic quinolone antibiotics. In a technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom. Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.
IDARUBICIN (58957-92-9)  
Idarubicin or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake.
7-Ethyl-10-hydroxycamptothecin (86639-52-3)  
SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.
camptothecin (7689-03-4)  
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E.
Pixantrone (144510-96-3, 144675-97-8)  
Pixantrone (rINN; trade name Pixuvri) is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent. The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials.
Aclacinomycin A (57576-44-0, 64520-15-6, 77448-81-8)  
Aclarubicin  ·  NSC-208734  ·  Aclaplastin
Aclarubicin (INN) or aclacinomycin A is an anthracycline drug that is used in the treatment of cancer. Soil bacteria Streptomyces galilaeus can produce aclarubicin. It can induce histone eviction from chromatin upon intercalation.
Fisetin (528-48-3)  
5-Desoxy-quercetin  ·  3,3',4',7-Tetrahydroxyflavone  ·  3,3',4',7-Tetrahydroxy-flavone
Fisetin (7,3′,4′-flavon-3-ol), is a plant polyphenol from the flavonoid group. It can be found in many plants, where it serves as a colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers.
Rubitecan (91421-42-0)  
Rubitecan (INN, marketing name Orathecin) is an oral topoisomerase inhibitor, developed by Supergen.
aclarubicin (57576-44-0)  
Aclacinomycin A  ·  NSC-208734  ·  Aclaplastin
Aclarubicin (INN) or aclacinomycin A is an anthracycline drug that is used in the treatment of cancer. Soil bacteria Streptomyces galilaeus can produce aclarubicin. It can induce histone eviction from chromatin upon intercalation.
Annamycin (92689-49-1)  
Annamycin is an anthracycline antibiotic being investigated for the treatment of cancer.
Daca (89459-25-6)  
Acridine carboxamide is an chemotherapy agent that is being studied in the treatment of cancer. It belongs to the family of drugs called topoisomerase inhibitors. While the agent was well tolerated in Phase II clinical trials, it did not show efficacy when tested against various types of cancers.
MENOGARIL (71628-96-1)  
Menogaril is an anthracycline analog of nogalamycin which was developed in late 1970s. It has even stronger anticancer activity than nogalamycin and has less toxicity than nogalamycin. However, its development for clinical use was cancelled.
Losoxantrone (88303-60-0)  
Losoxantrone (biantrazole) is a anthroquinone anthrapyrazole antineoplastic agent and analog of mitoxantrone. It is also sometimes known as DuP 941.
pirarubicin (72496-41-4)  
Théprubicine  ·  THP-doxorubicin  ·  4'-O-tetrapyranyldoxorubicin
Pirarubicin (INN) is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
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