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Vasodilators

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papaverine (61-25-6, 58-74-2)  
Papaverine Hydrochloride  ·  Pavabid  ·  Cerespan
Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm, vasospasm (especially those involving the intestines, heart, or brain), and occasionally in the treatment of erectile dysfunction. It is used in the treatment of acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic (morphine-related) opium alkaloids (opiates).
Cilostazol (73963-72-1)  
Pletal  ·  6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone  ·  OPC 13013
Cilostazol is a quinolinone-derivative medication used in the alleviation of the symptoms of intermittent claudication in individuals with peripheral vascular disease. It is manufactured by Otsuka Pharmaceutical Co. under the trade name Pletaal.
Vardenafil (224785-90-4, 224789-15-5)  
Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction that is sold under the trade names Levitra (Bayer AG, GSK, and SP), Staxyn in India, and Vivanza in Italy.
adenosine (5536-17-4, 58-61-7, 30143-02-3, 5682-25-7)  
Adenocard  ·  Adenoscan
Adenosine is a purine nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Derivatives of adenosine are widely found in nature and play an important role in biochemical processes, such as energy transfer—as adenosine triphosphate (ATP) and adenosine diphosphate (ADP)—as well as in signal transduction as cyclic adenosine monophosphate (cAMP). Adenosine itself is a neuromodulator, believed to play a role in promoting sleep and suppressing arousal.
prazosin (19216-56-9)  
Minipress  ·  Prazosin Hydrochloride  ·  Prazosin HCL
Prazosin, trade names Minipress, Vasoflex, Lentopres and Hypovase, is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD). It is an α1-blocker which acts as an inverse agonist at alpha-1 adrenergic receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine.
Tadalafil (171596-29-5)  
Tadalafil (INN) is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis see-AL-iss, and under the name Adcirca ad-SUR-kə for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction when the conditions coincide.
Vidarabine (5536-17-4, 24356-66-9)  
Adenine Arabinoside  ·  Ara A  ·  Arabinofuranosyladenine
9-|A-d-arabinofuranosyladenine (5536-17-4)  
Vidarabine  ·  Adenine Arabinoside  ·  Ara A
phentolamine (50-60-2)  
Regitine  ·  Phentolamine Mesylate  ·  Rogitine
Phentolamine (Regitine) is a reversible nonselective α-adrenergic antagonist.
Regadenoson (313348-27-5)  
Regadenoson (CVT-3146, Lexiscan) is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing. It produces hyperemia quickly and maintains it for a duration that is useful for radionuclide myocardial perfusion imaging. The selective nature of the drug makes it preferable to other stress agents such as adenosine, which are less selective and therefore cause more side-effects.
diazoxide (364-98-7)  
Hyperstat  ·  Proglycem
Diazoxide (INN; brand name Proglycem) is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels, preventing calcium flux across the sarcolemma and activation of the contractile apparatus. In the United States, this agent is only available in the oral form and is typically given in hospital settings.
pentoxifylline (6493-05-6)  
Trental  ·  Torental  ·  Pentoxil
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It is generic and sold under many brand names worldwide.
tolazoline (59-98-3)  
Priscoline  ·  Tolazoline Hydrochloride  ·  Priscol
Tolazoline is a non-selective competitive α-adrenergic receptor antagonist. It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT2A agonist drugs such as 25I-NBOMe, DOB and Bromodragonfly (prolonged severe vasoconstriction can lead to gangrene if untreated).
Amrinone (60719-84-8)  
Inocor  ·  Amrinone LAW Brand  ·  Cordemcura
Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR).
betahistine (5638-76-6)  
Serc  ·  PT 9  ·  Fidium
Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease. It was first registered in Europe in 1970 for the treatment of Ménière's disease.
NICORANDIL (65141-46-0)  
Nicorandil Aventis Brand  ·  Dancor  ·  Adancor
Nicorandil is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Angedil (in Romania, Poland), Dancor (in Switzerland), Nikoran,PCA (in India), Aprior (in the Philippines), Nitorubin (in Japan), and Sigmart (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States.
PRENYLAMINE (390-64-7)  
Corontin  ·  Difril  ·  Segontin
Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which was used as a vasodilator in the treatment of angina pectoris; it was introduced in the 1960s by German manufacturer Albert-Roussel pharma gmbh which was acquired by Hoechst AG in 1974 and which in turn became part of Sanofi Aventis in 2005. It was withdrawn from market worldwide in 1988 because it caused QT prolongation and Torsades de pointes which in turn caused sudden death. The cardiac side effects were not detected during clinical development, but only emerged after the drug was widely used.
trapidil (15421-84-8)  
UCB Brand of Trapidil  ·  Rocornal  ·  Trapymin
Trapidil is a vasodilator and an antiplatelet drug. It also acts as an antagonist of platelet-derived growth factor.
molsidomine (25717-80-0)  
SIN 10  ·  ct-Arzneimittel Brand of Molsidomine  ·  Alpharma Brand of Molsidomine
Molsidomine is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
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