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Voltage-gated sodium channel blockers

Categories

Amidines (5)
Antiarrhythmic agents (5)
Bases (chemistry) (5)
Drugs acting on the cardiovascular system (5)
Guanidines (5)
Neurotoxins (5)
Sodium channel blockers (5)
Adamantane-like molecules (4)
Analgesics (4)
Drugs acting on the nervous system (4)
Alkaloids (1)

TETRODOTOXIN (4368-28-9)  
Tarichatoxin  ·  Tetradotoxin  ·  Fugu Toxin
Tarichatoxin (4368-28-9)  
Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin. Although tetrodotoxin was discovered in these fish and found in several other aquatic animals (e.g., in blue-ringed octopuses, rough-skinned newts, and moon snails), it is actually produced by certain infecting or symbiotic bacteria like Pseudoalteromonas, Pseudomonas, and Vibrio as well as other species found in the animals.
SAXITOXIN (73603-72-2, 35523-89-8)  
Saxitoxin (STX) is a potent neurotoxin and the best-known paralytic shellfish toxin (PST). Ingestion of saxitoxin, usually by consumption of shellfish contaminated by toxic algal blooms, is responsible for the human illness known as paralytic shellfish poisoning (PSP). The term saxitoxin originates from the genus name of the butter clam (Saxidomus) from which it was first isolated.