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trc-canada.com, Antiparkinsonian agents

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Aripiprazole (129722-12-9)  
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.. It is recommended by some doctors and used in the treatment of schizophrenia and bipolar disorder.
methyldopa (555-30-6, 41372-08-1)  
Aldomet  ·  Methyldopate  ·  alpha Methyldopa
Methyldopa, sold under the brand name Aldomet among others, is a medication used for high blood pressure. It is one of the preferred treatments for high blood pressure in pregnancy. For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred.
amantadine (768-94-5)  
Aman  ·  Symmetrel  ·  Amantadine Hydrochloride
Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. It is the organic compound 1-adamantylamine or 1-aminoadamantane, meaning it consists of an adamantane backbone that has an amino group substituted at one of the four methyne positions.
carbidopa (28860-95-9)  
Lodosyn  ·  MK 486  ·  Methyldopahydrazine
Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa. This property is significant in that it allows a greater proportion of peripheral levodopa to cross the blood–brain barrier for central nervous system effect.
2-HYDROXYESTRONE (362-06-1)  
2-Hydroxyestrone (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a major metabolite of estrone and estradiol. It is formed irreversibly from estrone in the liver and to a lesser extent in other tissues via 2-hydroxylation mediated by cytochrome P450 enzymes, mainly the CYP3A and CYP1A subfamilies. 2-OHE1 is the most abundant catechol estrogen in the body.
D-Dopa (5796-17-8)  
Dopa  ·  Dihydroxyphenylalanine  ·  3,4 Dihydroxyphenylalanine
D-DOPA (D-3,4-dihydroxyphenylalanine; dextrodopa) is similar to L-DOPA (levodopa), but with opposite chirality. Levo- and dextro- rotation reference a molecule's ability to rotate planes of polarized light in either direction. Whereas L-DOPA is moderately effective in the treatment of Parkinson's disease (PD) and Dopamine-responsive dystonia (DRD) by stimulating the production of dopamine in the brain, D-DOPA is biologically inactive.
Talipexole (101626-70-4)  
Talipexole (B-HT920, Domnin) is a dopamine agonist that is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim; it was introduced in 1996. As of December 2014 it was not approved for marketing in the US nor in Europe. Talipexole is a D2 dopamine receptor agonist and interacts both pre- and post-synaptic receptors.

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TETRABENAZINE (58-46-8)  
Nitoman  ·  Orphan Brand of Tetrabenazine  ·  Tetrabenazine Orphan Brand
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is marketed under the trade names Nitoman in Canada and Xenazine in New Zealand, some parts of Europe and in the United States as an orphan drug. On August 15, 2008, the U.S.
Clozapine N-oxide (34233-69-7)  
8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine N-oxide
Dexpramipexole (104632-28-2)  
Dexpramipexole (KNS-760704) is a drug that was investigated by Knopp Biosciences and Biogen Idec for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The drug failed to show efficacy in terms of function or survival in a Phase III study of patients with ALS. More recently, dexpramipexole was shown in a Phase 2 open-label trial to reduce eosinophil counts and eliminate the need for corticosteroid treatment in a subset of patients with steroid-responsive hypereosinophilic syndrome.
ropinirole (91374-21-9)  
Ropinirole (INN; trade names Requip, Repreve, Ronirol, Adartrel) is a dopamine agonist of the non-ergoline class of medications. It is manufactured by GlaxoSmithKline (GSK), Cipla, Dr. Reddy's Laboratories and Sun Pharmaceutical.
Piribedil mesylate (52293-23-9)  
Piribedil  ·  ET 495  ·  Trivastal
LISURIDE (19875-60-6, 18016-80-3)  
Dopergin  ·  Schering Brand 2 of Lisuride Maleate  ·  Lisuride Maleate
Lisuride, sold under the brand names Dopergin, Proclacam, and Revanil, is an antiparkinson agent of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride is described as free base (see table on the right) and as hydrogen maleate salt. Lisuride is used to lower prolactin and, in low doses, to prevent migraine attacks.
Biperiden hydrochloride (1235-82-1)  
Biperiden  ·  Akineton  ·  Biperidene
Biperiden, sold under the brandname Akineton among others, is a medication used to treat Parkinson disease and certain drug-induced movement disorders. It is not recommended for tardive dyskinesias. It is taken by mouth, injection into a vein, or muscle.
piribedil (3605-01-4)  
ET 495  ·  Trivastal  ·  Piribedil Mesylate
Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.
trihexyphenidyl (144-11-6)  
Artane  ·  Trihexyphenidyl Hydrochloride  ·  Benzhexol
Trihexyphenidyl (Artane, Apo-Trihex, Parkin, Pacitane), also known as benzhexol, Ariane, and trihex, is an antiparkinsonian agent of the antimuscarinic class. It has been in clinical usage for decades.
sulpiride (15676-16-1)  
Sulp  ·  neogama  ·  Deponerton
Sulpiride (brand names Dogmatil ( DE, HK, SG, PH), Dolmatil (IE, UK), Eglonyl (RU, ZA), Espiride (ZA), Modal (IL), Prometar (UY), Sulpor (UK) and others) is an atypical antipsychotic drug (although some texts have referred to it as a typical antipsychotic) of the benzamide class used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purpose.
Cuvalit (19875-60-6)  
Lisuride  ·  Dopergin  ·  Schering Brand 2 of Lisuride Maleate
lisuride maleate (19875-60-6)  
Lisuride  ·  Dopergin  ·  Schering Brand 2 of Lisuride Maleate
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