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trc-canada.com, Cycloalkanes, Monoamine reuptake inhibitors

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amantadine (768-94-5)  
Aman  ·  Symmetrel  ·  Amantadine Hydrochloride
Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. It is the organic compound 1-adamantylamine or 1-aminoadamantane, meaning it consists of an adamantane backbone that has an amino group substituted at one of the four methyne positions.

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pargyline (555-57-7)  
Pargyline Hydrochloride
Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC50 for MAO-A is 0.01152 µmol/L and for MAO-B is 0.00820 µmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl". It was one of several MAO inhibitors introduced in the 1960s including nialamide, isocarboxazid, phenelzine, and tranylcypromine. By 2007 the drug was discontinued and as of 2014 there were no generic versions available in the US.
Brofaromine (63638-91-5)  
Brofaromine (proposed brand name Consonar) is a reversible inhibitor of monoamine oxidase A (RIMA) discovered by Ciba-Geigy. The compound was primarily researched in the treatment of depression and anxiety but its development was dropped before it was brought to market. Brofaromine also acts as a serotonin reuptake inhibitor, and its dual pharmacologic effects offered promise in the treatment of a wide spectrum of depressed patients while producing less severe anticholinergic side effects in comparison with older standard drugs like the tricyclic antidepressants.
para-Chloroamphetamine (64-12-0, 2275-84-5)  
Ly123362  ·  Ly 123362  ·  p-Chloroamphetamine
para-Chloroamphetamine (PCA), also known as 4-chloroamphetamine (4-CA), is a substituted amphetamine and monoamine releaser similar to MDMA, but with substantially higher neurotoxicity, thought to be due to the unrestrained release of both serotonin and dopamine by a metabolite. It is used as a neurotoxin by neurobiologists to selectively kill serotonergic neurons for research purposes, in the same way that 6-hydroxydopamine is used to kill dopaminergic neurons. However, the effects of the compound on experimental animals appear less encouraging.
N-Acetyl-5-hydroxytryptamine (1210-83-9)  
N-acetylserotonin  ·  N-acetylhydroxytryptamine
N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical precursor and intermediate in the endogenous production of melatonin from serotonin. It also has biological activity in its own right, including acting as a melatonin receptor agonist, an agonist of the TrkB, and having antioxidant effects.
2-Phenylpropylamine (582-22-9)  
beta-methylphenethylamine  ·  beta-methylphenylethylamine  ·  BMPEA compound
β-Methylphenethylamine (β-Me-PEA, BMPEA), or 1-amino-2-phenylpropane, is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. In appearance, it is a colorless or yellowish liquid.
NORFENFLURAMINE (673-18-7, 1886-26-6)  
Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. This side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in Europe, as both fenfluramine and benfluorex form norfenfluramine as an active metabolite.
Nisoxetine (53179-07-0, 57754-86-6, 57226-61-6)  
3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine  ·  LY 135252  ·  N-methyl-gamma-(2-methylphenoxy)phenylpropanolamine
Nisoxetine, originally synthesized in the Lilly research laboratories during the early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses. It currently has no clinical applications in humans, although it was originally researched as an antidepressant. Nisoxetine is now widely used in scientific research as a standard selective norepinephrine reuptake inhibitor.
2,5-Dimethoxy-4-ethylamphetamine (22004-32-6)  
2,5-Dimethoxy-4-ethylamphetamine (DOET, DOE, Hecate) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized by Alexander Shulgin, and was described in his book PiHKAL (Phenethylamines i Have Known And Loved).
3,4-Dimethoxybenzylamine (5763-61-1)  
3,4-DBA  ·  3,4-dimethoxybenzylamine monohydrochloride  ·  veratrylamine
MMDA (13674-05-0)  
MMDA (3-methoxy-4,5-methylenedioxyamphetamine; 5-methoxy-MDA) is a psychedelic and entactogen drug of the amphetamine class. It is an analogue of lophophine, MDA, and MDMA. MMDA was described by Alexander Shulgin in his book PiHKAL.
p-Fluoroamphetamine (459-02-9)  
4-Fluoroamphetamine (4-FA; 4-FMP; PAL-303; "Flux"), also known as para-fluoroamphetamine (PFA) is a psychoactive research chemical of the phenethylamine and substituted amphetamine chemical classes. It produces stimulant and entactogenic effects, and is described subjectively as being between amphetamine and MDMA. As a recreational drug, 4-FA is sometimes sold along with related compounds such as 2-fluoroamphetamine and 4-fluoromethamphetamine.
4-Methoxyphenethylamine (55-81-2)  
O-methyltyramine sulfate (2:1)  ·  O-methyltyramine hydrochloride  ·  p-methoxyphenylethylamine
tryptamine (61-54-1)  
3-(2-aminoethyl)indole  ·  tryptamine monohydrochloride  ·  tryptamine sulfate
Tryptamine is a monoamine alkaloid. It contains an indole ring structure, and is structurally similar to the amino acid tryptophan, from which the name derives. Tryptamine is found in trace amounts in the brains of mammals and is hypothesized to play a role as a neuromodulator or neurotransmitter.
3-Methoxyphenethylamine (2039-67-0)  
3-methoxy-4-hydroxyphenylethylamine  ·  3-methoxy-4-hydroxyphenylethylamine sulfate (2:1)  ·  3-methoxy-4-hydroxyphenylethylamine hydrochloride
Deprenyl (14611-51-9, 2323-36-6)  
Selegiline, also known as L-deprenyl, is a substituted phenethylamine. At normal clinical doses, it is a selective irreversible MAO-B inhibitor. In larger doses it loses its specificity and also inhibits MAO-A.
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