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trc-canada.com, PDE4 inhibitors

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Roflumilast (162401-32-3)  
Roflumilast (trade names Daxas, Daliresp) is a drug that acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). It has anti-inflammatory effects and is used as an orally administered drug for the treatment of inflammatory conditions of the lungs such as chronic obstructive pulmonary disease (COPD). In June 2010, it was approved in the EU for severe COPD associated with chronic bronchitis.
pentoxifylline (6493-05-6)  
Trental  ·  Torental  ·  Pentoxil
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It is generic and sold under many brand names worldwide.
luteolin (491-70-3)  
Luteoline  ·  3',4',5,7-Tetrahydroxy-Flavone  ·  3',4',5,7-Tetrahydroxyflavone
Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance.
propentofylline (55242-55-2)  
HWA 285  ·  1-(5'-oxohexyl)-3-methyl-7-propylxanthine  ·  HWA-285
Propentofylline (HWA 285) is a xanthine derivative with purported neuroprotective effects.
Cilomilast (153259-65-5)  
Cilomilast (INN, codenamed SB-207,499, proposed trade name Ariflo) is a drug which was developed for the treatment of respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD). It is orally active and acts as a selective phosphodiesterase-4 inhibitor. Phosphodiesterase (PDE) inhibitors, such as theophylline, have been used to treat COPD for centuries; however, the clinical benefits of these agents have never been shown to outweigh the risks of their numerous adverse effects.

Related Results:
Protein kinase inhibitor H-8 (84478-11-5)  
H8 protein kinase inhibitor  ·  N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide  ·  H-8 protein kinase inhibitor
AEIQS (84468-17-7)  
N-(2-aminoethyl)-5-isoquinolinesulfonamide  ·  H-9  ·  protein kinase C inhibitor H-9
APROTININ (9087-70-1)  
Trasylol  ·  Bovine Pancreatic Trypsin Inhibitor  ·  Antilysin
Iniprol (9087-70-1)  
Aprotinin  ·  Trasylol  ·  Bovine Pancreatic Trypsin Inhibitor
9087-70-1 (9087-70-1)  
Aprotinin  ·  Trasylol  ·  Bovine Pancreatic Trypsin Inhibitor
1,9-Pyrazoloanthrone (129-56-6)  
SP600125  ·  anthra(1,9-cd)pyrazol-6(2H)-one  ·  NSC75890
1,9-Pyrazoloanthrone is a chemical compound that is a derivative of anthrone. It is used in biochemical studies as an inhbitor of c-Jun N-terminal kinases (JNKs). Derivatives of 1,9-pyrazoloanthrone have a variety of biological activities.
nu6102 (444722-95-6)  
O(6)-cyclohexylmethoxy-2-(4'-sulfamoylanilino)purine
Imatinib (152459-95-5)  
Imatinib, sold under the brand names Gleevec among others, is a medication used to treat cancer. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that is Philadelphia chromosome-positive (Ph+) and certain types of gastrointestinal stromal tumors (GIST), systemic mastocytosis, and myelodysplastic syndrome. It is taken by mouth.
4-Hydroxyquinazoline (491-36-1)  
4(3H)-quinazolinone  ·  quinazolin-4-one
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