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Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.. It is recommended by some doctors and used in the treatment of schizophrenia and bipolar disorder.
(E)-Flupenthixol (53772-85-3, 2709-56-0)
Flupenthixol · Flupentixol · Fluanxol
Flupentixol (INN), also known as flupenthixol (former BAN), marketed under brand names such as Depixol and Fluanxol is a typical antipsychotic drug of the thioxanthene class. It was introduced in 1965 by Lundbeck. In addition to single drug preparations, it is also available as flupentixol/melitracen—a combination product containing both melitracen (a tricyclic antidepressant) and flupentixol.
3-methyl-1-phenyl-2-pyrazolin-5-one · MCI-186 · norantipyrine
Edaravone, sold as under the brand names Radicava and Radicut, is an intravenous medication used to help with recovery following a stroke and to treat amyotrophic lateral sclerosis (ALS). The label carries a warning about the potential for hypersensitivity reactions to edaravone, and adverse effects include bruising, gait disturbances, headache, skin inflammation, eczema, problems breathing, excess sugar in urine, and fungal skin infections. The mechanism by which edaravone might be effective is unknown.
Epipregnanolone (4406-35-3, 128-21-2)
Epipregnanolone, also known as 3β-hydroxy-5β-pregnan-20-one or 3β,5β-tetrahydroprogesterone (3β,5β-THP), is an endogenous neurosteroid. It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone. Epipregnanolone is biosynthesized from progesterone by the actions of 5β-reductase and 3β-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone as the intermediate in this two-step transformation.
Paraxanthine, or 1,7-dimethylxanthine, is a dimethyl derivative of xanthine, structurally related to caffeine. Like caffeine, paraxanthine is a psychoactive central nervous system (CNS) stimulant. It possesses a potency roughly equal to that of caffeine and is likely involved in the mediation of the effects of caffeine itself.
Cordycepin (75808-67-2, 73-03-0)
Cordycepin, or 3'-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the absence of the hydroxy group in the 3' position of its ribose part. It was initially extracted from the fungus Cordyceps militaris, but is now produced synthetically. Because cordycepin is similar to adenosine, some enzymes cannot discriminate between the two.
ethyl apovincaminate tartrate (1:1) · TCV-3B · Cavinton
Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine (sometimes described as "a synthetic ethyl ester of apovincamine"), an extract from the lesser periwinkle plant. Vinpocetine was first isolated from the plant in 1975 by the Hungarian chemist Csaba Szántay. The mass production of the synthetic compound was started in 1978 by the Hungarian pharmaceutical company Richter Gedeon.
ADRAFINIL (63547-13-7, 827603-92-9)
benzhydrylsulfinylacetohydroxamic acid · Olmifon · CRL-40028