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www.sigmaaldrich.com, Anti-inflammatory agents, Cyclic compounds

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Anti-inflammatory and antirheumatic products (29)
Drugs acting on the musculoskeletal system (29)
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SynQuest Laboratories (2)

Diclofenac (15307-86-5)  
Voltaren  ·  Diclofenac Sodium  ·  SR 38
Diclofenac (sold under a number of trade names) is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names. The name "diclofenac" derives from its chemical name: 2-(2,6-dichloranilino) phenylacetic acid.
celecoxib (169590-42-5)  
Celebrex  ·  SC58635  ·  SC-58635
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people two years or older. Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause.
piroxicam (36322-90-4)  
Feldene  ·  CP-16171  ·  CP16171
Valdecoxib (181695-72-7)  
Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. Valdecoxib was manufactured and marketed under the brand name Bextra by G.
ketorolac (66635-83-4, 74103-06-3)  
Ketorolac, sold under the brand name Toradol among others, is a nonsteroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives, used as an analgesic. It is considered a first-generation NSAID. Ketorolac acts by inhibiting the bodily synthesis of prostaglandins.
tolmetin (26171-23-3)  
Tolectin  ·  Tolmetin Sodium  ·  McN-2559
Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) of the heterocyclic acetic acid derivative class. It is used primarily to reduce hormones that cause pain, swelling, tenderness, and stiffness in conditions such as osteoarthritis and rheumatoid arthritis, including juvenile rheumatoid arthritis. In the United States it is marketed as Tolectin and comes as a tablet or capsule.
FLUOCINOLONE ACETONIDE (67-73-2)  
Capex  ·  Synalar  ·  Jellin
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity.
flurbiprofen (5104-49-4, 51543-38-5)  
Froben  ·  Ansaid  ·  Ocufen
Flurbiprofen is a member of the phenylalkanoic acid derivative family of nonsteroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Side effects are analogous to those of ibuprofen.
diflunisal (22494-42-4)  
Dolobid  ·  Dolocid  ·  Novo-Diflunisal
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, as MK647, after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, marketed by Merck & Co., but generic versions are now widely available.
sulindac (32004-68-5, 9000-14-0, 38194-50-2, 49627-22-7)  
Copal  ·  Clinoril  ·  Chibret
fluocinonide (356-12-7)  
Lidex  ·  Topsyn  ·  Lidemol
Fluocinonide (Fluonex, Lidex, Lidex-E, Lonide, Lyderm, and Vanos) is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort. The usual prescription concentration is 0.05% as a topical cream, ointment, solution, or gel.
DESONIDE (638-94-8)  
Tridesilon  ·  Desowen  ·  Desocort
Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory that has been available since the 1970s. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile and is available as a cream, ointment, lotion, and as a foam under the tradename Verdeso Foam.
Etoricoxib (202409-33-4)  
Etoricoxib (Arcoxia) is a selective COX-2 inhibitor from Merck & Co. Currently it is approved in more than 80 countries worldwide but not in the US, where the Food and Drug Administration (FDA) has required additional safety and efficacy data for etoricoxib before it will issue approval.
amcinonide (51022-69-6)  
Cyclocort  ·  Hermal brand of amcinonide  ·  Amciderm
Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis. Amcinonide can also be classified as a multi-functional small molecule corticosteroid, which has been approved by the FDA and is currently marketed as an ointment, lotion, or cream. It acts as both a transcription factor for responses to glucocorticoids and modulator for other transcription factors while also regulating phospholipase A2 activity.
nimesulide (51803-78-2)  
Aulin  ·  Nexen  ·  R 805
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with pain medication and fever reducing properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis, and primary dysmenorrhoea in adolescents and adults above 12 years old. Side effects may include liver problems.
Parecoxib (198470-84-7)  
Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx).
halcinonide (3093-35-4)  
Halog  ·  Halciderm  ·  SQ 18,566
Halcinonide is a high potency corticosteroid, in group II (second most potent group) under US classification. It is used topically (in a 0.05% cream provided as Halog) in the treatment of certain skin conditions.
tiaprofenic acid (103667-49-8, 33005-95-7)  
Surgam  ·  Nu-Tiaprofenic  ·  tiaprofenic acid, calcium salt
Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended in children.
2,3,5,6-Tetramethylpyrazine (1124-11-4)  
tetramethylpyrazine  ·  Liqustrazine  ·  chuanxiongzine
Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans. When purified, tetramethylpyrazine is a colorless solid. It is classifed as an alkylpyrazine.
Aceclofenac (89796-99-6)  
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.
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