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www.sigmaaldrich.com, Anti-inflammatory agents, Leukotriene antagonists

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Acids (1)
Anti-inflammatory and antirheumatic products (1)
Antiasthmatic drugs (1)
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Drugs acting on the musculoskeletal system (1)
Drugs acting on the respiratory system (1)
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amlexanox (68302-57-8)  
Aphthasol  ·  AA-673  ·  AA 673
Amlexanox (trade name Aphthasol) is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. This drug has been discontinued in the U.S.

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Phenidone (92-43-3)  
phenidone monohydrochloride
Phenidone (1-phenyl-3-pyrazolidinone) is an organic compound that is primarily used as a photographic developer. It has five to ten times the developing power as Metol. It also has low toxicity and, unlike some other developers, does not cause dermatitis upon skin contact.
histamine (51-45-6)  
Histamine Dihydrochloride  ·  Histamine Hydrochloride  ·  Peremin
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.
Prostaglandin E2 (363-24-6)  
PGE2  ·  Dinoprostone  ·  Prepidil Gel
Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin which is used as a medication. As a medication it is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. In babies it is used in those with congenital heart defects until surgery can be carried out.
ZILEUTON (111406-87-2)  
Zileuton (trade name ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used for the maintenance treatment of asthma. Zileuton was introduced in 1996 by Abbott Laboratories and is now marketed in two formulations by Cornerstone Therapeutics Inc. under the brand names ZYFLO and ZYFLO CR.
Pranlukast (150821-03-7, 103177-37-3)  
ONO-RS 411  ·  SB 205312  ·  8-(4 (4-phenylbutoxy)benzoyl)amino-2-(tetrazol-5'-yl)-4-oxo-4H-1-benzopyran
Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan.
SERATRODAST (112665-43-7)  
AA-2414  ·  AA 2414  ·  7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
Seratrodast (development name, AA-2414; marketed originally as Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma. It was the first TP receptor antagonist that was developed as an anti-asthmatic drug and received marketing approval in Japan in 1997. As of 2017 seratrodast was marketed as Bronica in Japan, and as Changnuo, Mai Xu Jia, Quan Kang Nuo in China.
Histamine dihydrochloride (56-92-8)  
Histamine  ·  Histamine Hydrochloride  ·  Peremin
Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML). It is a FDA-approved active ingredient for topical analgesic use and is available in such products as Australian Dream Cream, which is used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains.
celecoxib (169590-42-5)  
Celebrex  ·  SC58635  ·  SC-58635
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people two years or older. Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause.
Icatibant (130308-48-4, 138614-30-9)  
Icatibant, trade name Firazyr, is medication that has been approved by the European Commission for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency. It is not effective in angioedema caused by medication from the ACE inhibitor class, as shown in a 2017 trial. It is a peptidomimetic consisting of ten amino acids, which is a selective and specific antagonist of bradykinin B2 receptors.
TEPOXALIN (103475-41-8)  
Tepoxalin is a nonsteroidal anti-inflammatory drug approved for veterinary use in the United States and many other countries. It is primarily used to reduce inflammation and relief of pain caused by musculoskeletal disorders such as hip dysplasia and arthritis. It is generally marketed under the brand name Zubrin.
INDOMETHACIN SODIUM (7681-54-1)  
Indomethacin  ·  Indocin  ·  Indometacin
amlexanox (68302-57-8)  
Aphthasol  ·  AA-673  ·  AA 673
Amlexanox (trade name Aphthasol) is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. This drug has been discontinued in the U.S.
tiaramide hydrochloride (35941-71-0)  
tiaramide  ·  FK 1160  ·  NTA-194
TIARAMIDE (32527-55-2)  
FK 1160  ·  NTA-194  ·  Solantal
prostacyclin (61849-14-7)  
PGI2  ·  Epoprostenol  ·  Prostaglandin I2
Epoprostenol sodium (61849-14-7, 35121-78-9)  
Prostacyclin  ·  PGI2  ·  Epoprostenol
Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator. When used as a drug, it is also known as epoprostenol.
prostaglandin I2 (61849-14-7, 35121-78-9)  
Prostacyclin  ·  PGI2  ·  Epoprostenol
epoprostenol (136626-78-3, 61849-14-7, 35121-78-9)  
Prostacyclin  ·  PGI2  ·  Prostaglandin I2
Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator. When used as a drug, it is also known as epoprostenol.
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