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www.sigmaaldrich.com, Drugs acting on the genito-urinary system, Alpha blockers

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Antihypertensive agents (10)
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Aripiprazole (129722-12-9)  
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.. It is recommended by some doctors and used in the treatment of schizophrenia and bipolar disorder.
Risperidone (106266-06-2)  
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication. It is mainly used to treat schizophrenia, bipolar disorder, and irritability in people with autism. It is taken either by mouth or by injection into a muscle.
nicergoline (27848-84-6)  
Nicergolin neuraxpharm  ·  ergobel  ·  Krewel Brand of Nicergoline
Nicergoline (INN, marketed under the trade name Sermion) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.
Pipamperone (1893-33-0)  
R 3345  ·  Dipiperon  ·  1'-(3-(4-fluorobenzoyl)propyl)-(1,4'-bipiperidine) -4'-carboxamide
Pipamperone (INN, USAN, BAN), also known as carpiperone and floropipamide or fluoropipamide, and as floropipamide hydrochloride (JAN), is a typical antipsychotic of the butyrophenone family used in the treatment of schizophrenia. It is or has been marketed under brand names including Dipiperon, Dipiperal, Piperonil, Piperonyl, and Propitan. Pipamperone was discovered at Janssen Pharmaceutica in 1961, and entered clinical trials in the United States in 1963.
piribedil (3605-01-4)  
ET 495  ·  Trivastal  ·  Piribedil Mesylate
Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.
2-(1-Piperazinyl)pyrimidine (125523-53-7, 20980-22-7)  
MJ-13653  ·  1-(2-pyrimidinyl)piperazine  ·  MJ 13653
1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α2-adrenergic receptor (Ki = 7.3–40 nM) and, to a much lesser extent, as a partial agonist of the 5-HT1A receptor (Ki = 414 nM; Emax = 54%). It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic receptors.
Pizotifen (15574-96-6)  
Sandomigran  ·  Pizotyline  ·  BC 105
Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene-based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches.
Cyamemazine (3546-03-0)  
cyamamazine  ·  10-(3-dimethylamino-2-methylpropyl)phenothiazine-2-carbonitrile  ·  cyamepromazine
Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class which was introduced by Theraplix in France in 1972 and later in Portugal as well. It is used for the treatment of schizophrenia and, especially, for psychosis-associated anxiety, due to its unique anxiolytic efficacy. Cyamemazine differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α1-adrenergic, H1, and mACh receptor antagonism, it additionally produces potent blockade of several serotonin receptors, including 5-HT2A, 5-HT2C, and 5-HT7.
1-Benzylpiperazine (2759-28-6)  
1-benzylpiperazine hydrochloride  ·  1-benzylpiperazine tartrate  ·  1-benzylpiperazine dihydrochloride
Benzylpiperazine (BZP) is a recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity and seizures.
Metazosin (116728-65-5, 95549-92-1)  
Metazosin is an antihypertensive alpha-adrenergic antagonist.

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Telmisartan (144701-48-4)  
Telmisartan (INN) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. It was discovered by Boehringer Ingelheim and launched in 1999 as Micardis. In January 2014, Actavis as generic version of Micardis got appoval from FDA.
UNII-37420PJU4M (32634-95-0)  
17-acetoxy-6-methylene-4-pregnene-3,20-dione  ·  17 alpha acetoxy-6-methylene-4-pregnene-3,20-dione  ·  VP-2
Pregneninolone (434-03-7)  
Ethisterone  ·  Anhydrohydroxyprogesterone  ·  17 alpha Ethynyltestosterone
17-Hydroxypregnenolone (387-79-1)  
Hydroxypregnenolone  ·  17-Hydroxypregnenolone, (3beta,13alpha,17alpha)-Isomer  ·  17-Hydroxypregnenolone, (3alpha)-Isomer
17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase (CYP17A1) that is present in the adrenal and gonads. Peak levels are reached in humans at the end of puberty and then decline.
Aethisteron (434-03-7)  
Ethisterone  ·  Pregneninolone  ·  Anhydrohydroxyprogesterone
2,4-THIAZOLIDINEDIONE (2295-31-0)  
thiazolidinedione  ·  T-174  ·  2,4-thiazolidinedione potassium
The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s.
doxazosin (74191-85-8)  
Cardura  ·  Doxazosin Mesylate  ·  Progandol Neo
Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand names Cardura and Carduran, is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH). In March 2000, the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) study stopped its arm of the trial looking at alpha blockers, because doxazosin was less effective than a simple diuretic, and because patients on doxazosin had a 25% higher rate of cardiovascular disease and twice the rate of congestive heart failure as patients on diuretics. Pfizer, aware of the results before publication, launched a marketing campaign in early 2000, and sales were largely unaffected, despite the dangers highlighted by the study.
losartan (114798-26-4)  
Cozaar  ·  Losartan Potassium  ·  DuP 753
Losartan, sold under the trade name Cozaar among others, is a medication mainly used to treat high blood pressure. Other uses include for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth.
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