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www.sigmaaldrich.com, Drugs acting on the genito-urinary system, Antihypertensive agents, D4 antagonists, Drugs acting on the cardiovascular system, Alpha blockers, Psychoactive drugs, Drugs acting on the nervous system

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Alpha-1 blockers (1)
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D2 antagonists (1)
D3 antagonists (1)
Dopamine antagonists (1)
Drugs for benign prostatic hyperplasia (1)
Fluoroarenes (1)
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Psychopharmacology (1)
Six-membered rings (1)
Typical antipsychotics (1)
Urologicals (1)

Pipamperone (1893-33-0)  
R 3345  ·  Dipiperon  ·  1'-(3-(4-fluorobenzoyl)propyl)-(1,4'-bipiperidine) -4'-carboxamide
Pipamperone (INN, USAN, BAN), also known as carpiperone and floropipamide or fluoropipamide, and as floropipamide hydrochloride (JAN), is a typical antipsychotic of the butyrophenone family used in the treatment of schizophrenia. It is or has been marketed under brand names including Dipiperon, Dipiperal, Piperonil, Piperonyl, and Propitan. Pipamperone was discovered at Janssen Pharmaceutica in 1961, and entered clinical trials in the United States in 1963.

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1,3,5-tris(3-isocyanato-4-methylphenyl)-1,3,5-triazinane-2,4,6-trione (26603-40-7, 8060-82-0)  
brobenzoxaldine, broxyquinoline drug combination  ·  Intestopan  ·  Enteroquin
spironolactone (52-01-7)  
Aldactone  ·  Spirolactone  ·  NovoSpiroton
Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women, and as a part of feminizing hormone therapy in transgender women. Spironolactone is taken by mouth.
Telmisartan (144701-48-4)  
Telmisartan (INN) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. It was discovered by Boehringer Ingelheim and launched in 1999 as Micardis. In January 2014, Actavis as generic version of Micardis got appoval from FDA.
doxazosin (74191-85-8)  
Cardura  ·  Doxazosin Mesylate  ·  Progandol Neo
Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand names Cardura and Carduran, is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH). In March 2000, the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) study stopped its arm of the trial looking at alpha blockers, because doxazosin was less effective than a simple diuretic, and because patients on doxazosin had a 25% higher rate of cardiovascular disease and twice the rate of congestive heart failure as patients on diuretics. Pfizer, aware of the results before publication, launched a marketing campaign in early 2000, and sales were largely unaffected, despite the dangers highlighted by the study.
valsartan (137862-53-4)  
Valsartan (trade name Diovan) is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. It is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor.
2,4-THIAZOLIDINEDIONE (2295-31-0)  
thiazolidinedione  ·  T-174  ·  2,4-thiazolidinedione potassium
The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s.
Metformin hydrochloride (15537-72-1, 1115-70-4)  
Metformin  ·  Glucophage  ·  Metformin HCl
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.
loperamide (53179-11-6)  
Imodium  ·  Loperamide Hydrochloride  ·  Loperamide Monohydrochloride
Loperamide, sold under the brand name Imodium among others, is a medication used to decrease the frequency of diarrhea. It is often used for this purpose in gastroenteritis, inflammatory bowel disease, and short bowel syndrome. It is not recommended for those with blood in the stool.
Agomelatine (138112-76-2)  
Agomelatine (brand names Valdoxan, Melitor, Thymanax) is an atypical antidepressant developed by the pharmaceutical company Servier. It is marketed for the treatment of major depressive disorder, primarily for its relatively favorable side effect profile: it avoids the weight gain, sexual dysfunction, and severe withdrawal associated with the most commonly used classes of antidepressants (SSRIs, SNRIs, tricyclics), while providing similar therapeutic benefit. Due to its distinctive mechanism of action, agomelatine is also studied for its effects on sleep regulation.
memantine (19982-08-2)  
Namenda  ·  D 145  ·  D145
Memantine is used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors. It was first synthesized by Eli Lilly and Company in 1968 as a potential agent to treat diabetes; the NMDA activity was discovered in the 1980s.
Trazodone hydrochloride (19666-36-5, 25332-39-2)  
Trazodone  ·  Desyrel  ·  Trittico
Trazodone, sold under many brand names worldwide, is an atypical antidepressant of the serotonin antagonist and reuptake inhibitor (SARI) class. It is a phenylpiperazine compound. Trazodone also has anti-anxiety (anxiolytic) and sleep-inducing (hypnotic) effects.
PHENOTHIAZINE (92-84-2)  
phenosan
Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Although the parent compound has no uses, derivatives of phenothiazine are highly bioactive and have widespread use and rich history. The derivative chlorpromazine revolutionized the field of psychiatry and allergy treatment.
dihydroergotamine (511-12-6, 6190-39-2)  
Agit  ·  Dihydroergotamine Mesylate  ·  Migranal
Dihydroergotamine (DHE) is an ergot alkaloid used to treat migraines. It is a derivative of ergotamine. It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan.
thalidomide (50-35-1)  
Thalomid  ·  Celgene Brand of Thalidomide  ·  Sedoval
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs. Today, thalidomide is used mainly as a treatment of certain cancers (multiple myeloma) and of a complication of leprosy. Thalidomide was first marketed in 1957 in West Germany under the trade-name Contergan.
clozapine (5786-21-0)  
Clozaril  ·  Leponex
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication. It is mainly used for schizophrenia that does not improve following the use of other antipsychotic medications. In those with schizophrenia and schizoaffective disorder it may decrease the rate of suicidal behavior.
Labetalol hydrochloride (32780-64-6, 72487-34-4)  
Labetalol  ·  Normodyne  ·  Trandate
Labetalol is a medication used to treat high blood pressure. It can be given intravenously in severe hypertensive situations, or by mouth for long term hypertension management. Its dose and use is limited by its main side effect—postural hypotension, where there is a substantial drop in blood pressure when standing up.
lamotrigine (84057-84-1)  
Lamictal  ·  3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine  ·  Labileno
Lamotrigine, sold as the brandname Lamictal among other, is an anticonvulsant medication used to treat epilepsy and bipolar disorder. For epilepsy, this includes focal seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome. In bipolar, it is used to treat acute episodes of depression, rapid cycling in bipolar type II, and prevent recurrence in bipolar type I.
Dihydroergotamine mesylate (6190-39-2, 11032-41-0)  
Agit  ·  Dihydroergotamine  ·  Migranal
Dihydroergotamine (DHE) is an ergot alkaloid used to treat migraines. It is a derivative of ergotamine. It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan.
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