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www.sigmaaldrich.com, Drugs acting on the genito-urinary system, Antihypertensive agents, D4 antagonists, Drugs acting on the nervous system

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Alpha blockers (1)
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Alpha-2 blockers (1)
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D2 antagonists (1)
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Piperidines (1)
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Psychopharmacology (1)
Six-membered rings (1)
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Pipamperone (1893-33-0)  
R 3345  ·  Dipiperon  ·  1'-(3-(4-fluorobenzoyl)propyl)-(1,4'-bipiperidine) -4'-carboxamide
Pipamperone (INN, USAN, BAN), also known as carpiperone and floropipamide or fluoropipamide, and as floropipamide hydrochloride (JAN), is a typical antipsychotic of the butyrophenone family used in the treatment of schizophrenia. It is or has been marketed under brand names including Dipiperon, Dipiperal, Piperonil, Piperonyl, and Propitan. Pipamperone was discovered at Janssen Pharmaceutica in 1961, and entered clinical trials in the United States in 1963.

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1,3,5-tris(3-isocyanato-4-methylphenyl)-1,3,5-triazinane-2,4,6-trione (26603-40-7, 8060-82-0)  
brobenzoxaldine, broxyquinoline drug combination  ·  Intestopan  ·  Enteroquin
Telmisartan (144701-48-4)  
Telmisartan (INN) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. It was discovered by Boehringer Ingelheim and launched in 1999 as Micardis. In January 2014, Actavis as generic version of Micardis got appoval from FDA.
doxazosin (74191-85-8)  
Cardura  ·  Doxazosin Mesylate  ·  Progandol Neo
Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand names Cardura and Carduran, is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH). In March 2000, the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) study stopped its arm of the trial looking at alpha blockers, because doxazosin was less effective than a simple diuretic, and because patients on doxazosin had a 25% higher rate of cardiovascular disease and twice the rate of congestive heart failure as patients on diuretics. Pfizer, aware of the results before publication, launched a marketing campaign in early 2000, and sales were largely unaffected, despite the dangers highlighted by the study.
spironolactone (52-01-7)  
Aldactone  ·  Spirolactone  ·  NovoSpiroton
Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women, and as a part of feminizing hormone therapy in transgender women. Spironolactone is taken by mouth.
thalidomide (50-35-1)  
Thalomid  ·  Celgene Brand of Thalidomide  ·  Sedoval
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs. Today, thalidomide is used mainly as a treatment of certain cancers (multiple myeloma) and of a complication of leprosy. Thalidomide was first marketed in 1957 in West Germany under the trade-name Contergan.
loperamide (53179-11-6)  
Imodium  ·  Loperamide Hydrochloride  ·  Loperamide Monohydrochloride
Loperamide, sold under the brand name Imodium among others, is a medication used to decrease the frequency of diarrhea. It is often used for this purpose in gastroenteritis, inflammatory bowel disease, and short bowel syndrome. It is not recommended for those with blood in the stool.
Metformin hydrochloride (15537-72-1, 1115-70-4)  
Metformin  ·  Glucophage  ·  Metformin HCl
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.
Melatonin (8041-44-9, 73-31-4)  
Melatonin, also known as N-acetyl-5-methoxy tryptamine, is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness. Melatonin is also produced in plants where it functions as a first line of defense against oxidative stress. In animals, melatonin is involved in the entrainment (synchronization) of the circadian rhythms including sleep-wake timing, blood pressure regulation, seasonal reproduction, and many others.
valsartan (137862-53-4)  
Valsartan (trade name Diovan) is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. It is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor.
dihydroergotamine (511-12-6, 6190-39-2)  
Agit  ·  Dihydroergotamine Mesylate  ·  Migranal
Dihydroergotamine (DHE) is an ergot alkaloid used to treat migraines. It is a derivative of ergotamine. It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan.
Dihydroergotamine mesylate (6190-39-2, 11032-41-0)  
Agit  ·  Dihydroergotamine  ·  Migranal
Dihydroergotamine (DHE) is an ergot alkaloid used to treat migraines. It is a derivative of ergotamine. It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan.
2,4-THIAZOLIDINEDIONE (2295-31-0)  
thiazolidinedione  ·  T-174  ·  2,4-thiazolidinedione potassium
The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s.
MOXONIDINE (75438-57-2)  
Moxon  ·  Zint  ·  Cynt
Moxonidine (INN) is a new-generation centrally acting antihypertensive drug licensed for the treatment of mild to moderate essential hypertension. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure. In addition, it demonstrates favourable effects on parameters of the insulin resistance syndrome, apparently independent of blood pressure reduction.
metformin (1115-70-4, 657-24-9)  
Glucophage  ·  Metformin Hydrochloride  ·  Metformin HCl
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.
PHENOTHIAZINE (92-84-2)  
phenosan
Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Although the parent compound has no uses, derivatives of phenothiazine are highly bioactive and have widespread use and rich history. The derivative chlorpromazine revolutionized the field of psychiatry and allergy treatment.
chlorothiazide (58-94-6)  
Chlorothiazide sodium (Diuril) is an organic compound used as a diuretic and as an antihypertensive. It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day.
indapamide (26807-65-8)  
S 1520  ·  SE1520  ·  S1520
Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
midodrine (133163-28-7, 42794-76-3)  
Midon  ·  ProAmatine  ·  Midodrine Hydrochloride
Midodrine (brand names Amatine, ProAmatine, Gutron, Bramox)is a vasopressor/antihypotensive agent. Midodrine was approved in the United States by the Food and Drug Administration (FDA) in 1996 for the treatment of dysautonomia and orthostatic hypotension. In August 2010, the FDA proposed withdrawing this approval because the manufacturer, Shire plc, has failed to complete required studies after the medicine reached the market.
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