www.sigmaaldrich.com, Drugs acting on the genito-urinary system, CYP17A1 inhibitors, Anti-diabetic drugs, Antiglucocorticoids, Six-membered rings, Cyclic compounds
Hormonal agents (2)
PPAR agonists (2)
Sex hormones (2)
AK Scientific (2)
Oakwood Chemical (1)
TCI Chemicals (1)
Actos · pioglitazone hydrochloride · U72,107A
Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione (TZD) class with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. While pioglitazone does decrease blood sugar levels, studies on the main cardiovascular outcomes have not yielded statistically significant results. Its cardiovascular safety profile compares favorably with that of rosiglitazone, which was withdrawn from some markets after concerns about an increased risk of cardiac events.
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.
5-bromosalicyl-4'-chloranilide · salifungin
Bromochlorosalicylanilide is an antifungal. It may cause allergic contact dermatitis in some individuals.
7-chloro-1H-indole-2,3-dione · 7477-63-6
4(3H)-quinazolinone · quinazolin-4-one
Quinazoline is a organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water.
Compound VII (98033-68-2)
WIN 53338 · WIN-53338 · WIN53338
Thalomid · Celgene Brand of Thalidomide · Sedoval
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs. Today, thalidomide is used mainly as a treatment of certain cancers (multiple myeloma) and of a complication of leprosy. Thalidomide was first marketed in 1957 in West Germany under the trade-name Contergan.