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www.sigmaaldrich.com, Drugs acting on the genito-urinary system, CYP17A1 inhibitors, Anti-diabetic drugs, Antiglucocorticoids, matrixscientific.com, Antiandrogens

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rosiglitazone (122320-73-4)  
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.

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formestane (566-48-3)  
Formestane, sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced.
bicalutamide (90357-06-5)  
Casodex  ·  4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide  ·  ICI 176334
Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer. It is typically used together with a gonadotropin-releasing hormone (GnRH) analogue or surgical removal of the testicles to treat advanced prostate cancer. Bicalutamide may also be used to treat excessive hair growth in women, as a component of feminizing hormone therapy for transgender women, to treat early puberty in boys, and to prevent overly long-lasting erections in men.
nilutamide (63612-50-0)  
Nilandron  ·  Anandron  ·  RU 23908
Nilutamide, sold under the brand names Nilandron and Anandron, is a nonsteroidal antiandrogen (NSAA) which is used in the treatment of prostate cancer. It has also been studied as a component of feminizing hormone therapy for transgender women and to treat acne and seborrhea in women. It is taken by mouth.
raloxifene (84449-90-1)  
Raloxifene, sold under the brand name Evista among others, is a medication which is used in the prevention and treatment of osteoporosis in postmenopausal women and to reduce the risk of breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer. It is taken by mouth. Side effects of raloxifene include hot flashes, leg cramps, and an increased risk of blood clots and other cardiovascular events such as stroke.
flutamide (13311-84-7)  
Eulexin  ·  Euflex  ·  SCH 13521
Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer. It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women. It is taken by mouth, usually three times per day.
1,3,5-tris(3-isocyanato-4-methylphenyl)-1,3,5-triazinane-2,4,6-trione (26603-40-7, 8060-82-0)  
brobenzoxaldine, broxyquinoline drug combination  ·  Intestopan  ·  Enteroquin
thalidomide (50-35-1)  
Thalomid  ·  Celgene Brand of Thalidomide  ·  Sedoval
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs. Today, thalidomide is used mainly as a treatment of certain cancers (multiple myeloma) and of a complication of leprosy. Thalidomide was first marketed in 1957 in West Germany under the trade-name Contergan.
metformin (1115-70-4, 657-24-9)  
Glucophage  ·  Metformin Hydrochloride  ·  Metformin HCl
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.
Metformin hydrochloride (15537-72-1, 1115-70-4)  
Metformin  ·  Glucophage  ·  Metformin HCl
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.
Tamoxifen citrate (54965-24-1)  
Tamoxifen  ·  Nolvadex  ·  ICI 46,474
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome.
tamoxifen (13002-65-8, 10540-29-1)  
Nolvadex  ·  Tamoxifen Citrate  ·  ICI 46,474
aminoglutethimide (125-84-8)  
Cytadren  ·  Ciba Vision Brand of Aminoglutethimide  ·  Orimeten
Aminoglutethimide is an anti-steroid drug marketed under the tradename Cytadren by Novartis around the world. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also used by bodybuilders.
stanozolol (10418-03-8, 302-96-5)  
Winstrol  ·  Stanazolol  ·  Stromba
Stanozolol, sold under many brand names, is an androgen and anabolic steroid (AAS) medication which was derived from dihydrotestosterone (DHT). It was developed by American pharmaceutical company Winthrop Laboratories (Sterling Drug) in 1962, and has been approved by the Food and Drug Administration for human use, though it is no longer marketed in this country. It is also used in veterinary medicine.
2,4-THIAZOLIDINEDIONE (2295-31-0)  
thiazolidinedione  ·  T-174  ·  2,4-thiazolidinedione potassium
The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s.
DROLOXIFENE CITRATE (97752-20-0)  
droloxifene  ·  3-hydroxytamoxifen  ·  FK-435
Imatinib (152459-95-5)  
Imatinib, sold under the brand names Gleevec among others, is a medication used to treat cancer. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that is Philadelphia chromosome-positive (Ph+) and certain types of gastrointestinal stromal tumors (GIST), systemic mastocytosis, and myelodysplastic syndrome. It is taken by mouth.
celecoxib (169590-42-5)  
Celebrex  ·  SC58635  ·  SC-58635
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people two years or older. Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause.
anastrozole (120511-73-1)  
Arimidex  ·  anastrazole  ·  Zeneca brand of anastrozole
Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk.
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