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www.sigmaaldrich.com, Drugs acting on the genito-urinary system, CYP17A1 inhibitors, Anti-diabetic drugs, Hormonal agents, Sex hormones, Pyridines

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Drugs acting on the gastrointestinal system and metabolism (2)
PPAR agonists (2)
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Six-membered rings (2)
Systemic hormonal preparations (2)
Thiazolidinediones (2)

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Pioglitazone (111025-46-8)  
Actos  ·  pioglitazone hydrochloride  ·  U72,107A
Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione (TZD) class with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. While pioglitazone does decrease blood sugar levels, studies on the main cardiovascular outcomes have not yielded statistically significant results. Its cardiovascular safety profile compares favorably with that of rosiglitazone, which was withdrawn from some markets after concerns about an increased risk of cardiac events.
rosiglitazone (122320-73-4)  
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.

Related Results:
2,4-THIAZOLIDINEDIONE (2295-31-0)  
thiazolidinedione  ·  T-174  ·  2,4-thiazolidinedione potassium
The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s.
thalidomide (50-35-1)  
Thalomid  ·  Celgene Brand of Thalidomide  ·  Sedoval
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs. Today, thalidomide is used mainly as a treatment of certain cancers (multiple myeloma) and of a complication of leprosy. Thalidomide was first marketed in 1957 in West Germany under the trade-name Contergan.
1,3,5-tris(3-isocyanato-4-methylphenyl)-1,3,5-triazinane-2,4,6-trione (26603-40-7, 8060-82-0)  
brobenzoxaldine, broxyquinoline drug combination  ·  Intestopan  ·  Enteroquin
5-Bromo-4'-chlorosalicylanilide (3679-64-9)  
5-bromosalicyl-4'-chloranilide  ·  salifungin
Bromochlorosalicylanilide is an antifungal. It may cause allergic contact dermatitis in some individuals.
BENZIMIDAZOLE (51-17-2)  
benzimidazole monohydrochloride  ·  benzimidazole mononitrate
Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. It is a colorless solid.
5-Aminobenzimidazole (934-22-5)  
5-aminobenzimidazole hydrochloride
Melatonin (8041-44-9, 73-31-4)  
Melatonin, also known as N-acetyl-5-methoxy tryptamine, is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness. Melatonin is also produced in plants where it functions as a first line of defense against oxidative stress. In animals, melatonin is involved in the entrainment (synchronization) of the circadian rhythms including sleep-wake timing, blood pressure regulation, seasonal reproduction, and many others.
Lepidine (491-35-0)  
4-methylquinoline  ·  4-methylquinoline hydrochloride
Lepidine, or 4-methylquinoline, is a heterocyclic aromatic organic compound. Its methyl group is fairly acidic, allowing for condensations to occur at this position, especially when the nitrogen is quaternized. It is used in the preparation of certain dyes.
4-Hydroxyquinazoline (491-36-1)  
4(3H)-quinazolinone  ·  quinazolin-4-one
N-(Hydroxymethyl)phthalimide (118-29-6)  
N-hydroxymethylphthalimide
tolazamide (1156-19-0)  
Tolinase  ·  Pharmacia Brand of Tolazamide
Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
2-HYDROXYPYRIDINE (72762-00-6, 37342-64-6, 142-08-5)  
2-pyridinone  ·  2-pyridone  ·  2-hydroxypyridine sodium salt
2-Pyridone is an organic compound with the formula C 5H 4NH(O). It is a colourless solid. It is well known to form hydrogen bonded dimers and it is also a classic case of a compound that exists as tautomers.
QUINAZOLINE (253-82-7)  
Quinazoline is a organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water.
2-AMINOTHIAZOLE (96-50-4)  
T157602  ·  2-aminothiazole sulfate (1:1)  ·  2-aminothiazole mononitrate
2-Aminothiazole is a heterocyclic amine featuring an thiazole core. It can also be considered a cyclic isothiourea. It possesses an odor similar to pyridine and is soluble in water, alcohols and diethyl ether.
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