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www.sigmaaldrich.com, Drugs acting on the genito-urinary system, Synthetic estrogens, Aromatase inhibitors

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Androgens and anabolic steroids (1)
Consumer Ingredients (1)
Hormonal agents (1)
Pharmaceuticals (1)
Progestogens (1)
Sex hormones (1)
Systemic hormonal preparations (1)

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Toronto Research Chemicals (1)

norethindrone (68-22-4)  
Norethisterone  ·  Micronor  ·  Norlutin
Norethisterone (NET), also known as norethindrone, is a medication that is used in combination with estrogen or alone in hormonal contraceptives, menopausal hormone therapy, and in the treatment of gynecological disorders. It is a synthetic progestogen (or a progestin) of the 19-nortestosterone group and has similar effects to those of natural progesterone, including suppression of gonadotropins, ovulation inhibition, and endometrial transformation. In addition to its progestogenic activity, NET also has weak androgenic and estrogenic effects at high dosages.

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formestane (566-48-3)  
Formestane, sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced.
bicalutamide (90357-06-5)  
Casodex  ·  4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide  ·  ICI 176334
Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer. It is typically used together with a gonadotropin-releasing hormone (GnRH) analogue or surgical removal of the testicles to treat advanced prostate cancer. Bicalutamide may also be used to treat excessive hair growth in women, as a component of feminizing hormone therapy for transgender women, to treat early puberty in boys, and to prevent overly long-lasting erections in men.
letrozole (112809-51-5)  
Femara  ·  CGS 20267  ·  Fémara
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor which is used in the treatment of hormonally-responsive breast cancer after surgery.
Tamoxifen citrate (54965-24-1)  
Tamoxifen  ·  Nolvadex  ·  ICI 46,474
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome.
tamoxifen (13002-65-8, 10540-29-1)  
Nolvadex  ·  Tamoxifen Citrate  ·  ICI 46,474
aminoglutethimide (125-84-8)  
Cytadren  ·  Ciba Vision Brand of Aminoglutethimide  ·  Orimeten
Aminoglutethimide is an anti-steroid drug marketed under the tradename Cytadren by Novartis around the world. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also used by bodybuilders.
ethisterone (434-03-7)  
Pregneninolone  ·  Anhydrohydroxyprogesterone  ·  17 alpha Ethynyltestosterone
Ethisterone (brand names Proluton C, Pranone among others), also known as ethinyltestosterone, pregneninolone, or anhydrohydroxyprogesterone, is a progestin with androgenic activity which was derived from testosterone and was introduced for medical use in 1939. It was the second progestogen to be marketed (intramuscular progesterone was introduced as Proluton in 1934) and was both the first orally active progestogen and the first progestin (synthetic progestogen) to be introduced. Although ethisterone has largely been superseded by newer drugs and is now little used, it reportedly continues to be available in some countries.
raloxifene (84449-90-1)  
Raloxifene, sold under the brand name Evista among others, is a medication which is used in the prevention and treatment of osteoporosis in postmenopausal women and to reduce the risk of breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer. It is taken by mouth. Side effects of raloxifene include hot flashes, leg cramps, and an increased risk of blood clots and other cardiovascular events such as stroke.
EXEMESTANE (107868-30-4)  
Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow.
progesterone (57-83-0)  
Pregnenedione  ·  Progesterone, (13 alpha,17 alpha)-(+-)-Isomer  ·  Progesterone, (9 beta,10 alpha)-Isomer
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens, and is the major progestogen in the body. Progesterone has a variety of important functions in the body.
flutamide (13311-84-7)  
Eulexin  ·  Euflex  ·  SCH 13521
Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer. It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women. It is taken by mouth, usually three times per day.
diethylstilbestrol (6898-97-1, 56-53-1, 22610-99-7, 64-67-5)  
Stilbestrol  ·  Distilbène  ·  Stilbene Estrogen
ethinyl estradiol (57-63-6)  
Estinyl  ·  Ethinyloestradiol  ·  Ethynyl Estradiol
Ethinylestriol (EE3), or 17α-ethynylestriol, also known as 17α-ethynylestra-1,3,5(10)-triene-3,16α,17β-triol, is a synthetic, steroidal estrogen that was never marketed. Nilestriol, the 3-cyclopentyl ether of ethinylestriol, is a prodrug of ethinylestriol, and is a more potent estrogen in comparison, but, similarly to ethinylestriol, was never marketed. Ethinylestriol has been found to reduce the risk of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary cancer when given as a prophylactic in animal models, while other estrogens like ethinylestradiol and diethylstilbestrol were ineffective.
estrone (19973-76-3, 53-16-7)  
Folliculin  ·  Kestrone  ·  Wehgen
Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue.
estradiol (50-28-2, 73459-61-7)  
Oestradiol  ·  Estrace  ·  Vivelle
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips, and a feminine pattern of fat distribution in women and is important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus, and vagina during puberty, adulthood, and pregnancy.
Dienogest (65928-58-7)  
Dienogest, sold under the brand names Dinagest, Natazia, Qlaira, Valette, and Visanne among others, is a progestin which is available both in combination with estrogen for use in hormonal contraception and menopausal hormone therapy and by itself for the treatment of endometriosis. It has some antiandrogenic activity in addition to its progestogenic effects and as a result may improve symptoms of androgen-dependent conditions like acne.
methyltestosterone (262423-02-9, 58-18-4)  
Android  ·  Oreton  ·  Metandren
Methyltestosterone, sold under the brand names Android, Metandren, and Testred among others, is an androgen and anabolic steroid (AAS) medication which is used in the treatment of low testosterone levels in men, delayed puberty in boys, at low doses as a component of menopausal hormone therapy for menopausal symptoms like hot flashes, osteoporosis, and low sexual desire in women, and to treat breast cancer in women. It is taken by mouth. Side effects of methyltestosterone include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.
DROLOXIFENE CITRATE (97752-20-0)  
droloxifene  ·  3-hydroxytamoxifen  ·  FK-435
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