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www.sigmaaldrich.com, Drugs acting on the genito-urinary system

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METHAMPHETAMINE (51-57-0, 537-46-2)  
Desoxyn  ·  Methylamphetamine  ·  Methamphetamine Hydrochloride
Methamphetamine (contracted from N-methylamphetamine) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms.
Triclocarban (101-20-2)  
trichlorocarbanilide  ·  Cutisan  ·  Septivon
Triclocarban is an antibacterial agent common in personal care products like soaps and lotions as well as in the medical field, for which it was originally developed. Studies on its antibacterial qualities and mechanisms are growing. Research suggests that it is similar in its mechanism to triclosan and is effective in fighting infections by targeting the growth of bacteria such as Staphylococcus aureus.
Pioglitazone (111025-46-8)  
Actos  ·  pioglitazone hydrochloride  ·  U72,107A
Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione (TZD) class with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. While pioglitazone does decrease blood sugar levels, studies on the main cardiovascular outcomes have not yielded statistically significant results. Its cardiovascular safety profile compares favorably with that of rosiglitazone, which was withdrawn from some markets after concerns about an increased risk of cardiac events.
OXYTOCIN (50-56-6)  
Pitocin  ·  Syntocinon  ·  Ocytocin
Oxytocin (Oxt; , ) is a peptide hormone and neuropeptide. Oxytocin is normally produced by the paraventricular nucleus of the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, sexual reproduction in both sexes, and during and after childbirth.
rosiglitazone (122320-73-4)  
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.
digitoxin (8006-96-0, 71-63-6, 87112-48-9)  
Digitaline Nativelle  ·  corax Brand of Digitoxin  ·  Chauvin Brand of Digitoxin
Digitoxin is a cardiac glycoside. It is a phytosteroid and is similar in structure and effects to digoxin (though the effects are longer-lasting). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function.
BISPHENOL A DIGLYCIDYL ETHER (1675-54-3, 500008-19-5)  
DGEBA  ·  DGEBPA  ·  2,2-bis(p-glycidyloxyphenyl)propane
Bisphenol A diglycidyl ether (commonly abbreviated BADGE or DGEBA) is an organic compound used as constituent of epoxy resins. The compound is a colorless solid (commercial samples can appear yellow) that melts slightly above room temperature.
Prostaglandin E1 (745-65-3, 119314-69-1)  
Muse  ·  Alprostadil  ·  PGE1
kaempferol (520-18-3)  
kempferol  ·  3,4',5,7-tetrahydroxyflavone
Kaempferol is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods. Kaempferol is a yellow crystalline solid with a melting point of 276–278 °C (529–532 °F). It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO.
Dehydroepiandrosterone (53-43-0)  
DHEA  ·  Dehydroisoandrosterone  ·  Androstenolone
Prasterone, also known as dehydroepiandrosterone (DHEA), is a naturally occurring steroid which is used as a supplement and medication. It is an androstane derivative and a precursor of steroid hormones like testosterone and estradiol. Prasterone has weak androgenic activity, weak estrogenic activity, and neurosteroid activity, and acts as a prohormone of androgens and estrogens depending on its dosage and route of administration.
dienestrol (35495-11-5, 84-17-3, 13029-44-2)  
Dienoestrol  ·  Ortho Dienestrol  ·  Dienestrol, (Z,E)-Isomer
Dienestrol (INN, USAN) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others), also known as dienoestrol (BAN), is a synthetic nonsteroidal estrogen of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe. It was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene.
clotrimazole (23593-75-1)  
Lotrimin  ·  Mycelex  ·  Canesten
Clotrimazole, sold under the brand name Canesten among others, is an antifungal medication. It is used to treat vaginal yeast infections, oral thrush, diaper rash, pityriasis versicolor, and types of ringworm including athlete's foot and jock itch. It can be taken by mouth or applied as a cream to the skin or in the vagina.
4-HYDROXYBENZOIC ACID (99-96-7)  
4-hydroxybenzoic acid, calcium salt  ·  sodium p-hydroxybenzoate tetrahydrate  ·  4-hydroxybenzoic acid, dipotassium salt
4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions.
troglitazone (97322-87-7)  
Troglitazone (Rezulin, Resulin, Romozin, Noscal) is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for patients with diabetes mellitus type 2. It was developed by Daiichi Sankyo (Japan).
hydroxyprogesterone (604-09-1, 68-96-2)  
17 Hydroxyprogesterone  ·  17 alpha Hydroxyprogesterone  ·  17 alpha-Hydroxyprogesterone
Hydroxyprogesterone (OHP) may refer to: 3α-Hydroxyprogesterone (3α-dihydroprogesterone) 3β-Hydroxyprogesterone (3β-dihydroprogesterone) 11α-Hydroxyprogesterone 11β-Hydroxyprogesterone (21-deoxycorticosterone) 16α-Hydroxyprogesterone 17α-Hydroxyprogesterone 20α-Hydroxyprogesterone 21-Hydroxyprogesterone (11-deoxycorticosterone)
trans-Anethole (4180-23-8, 85681-56-7, 50770-19-9, 104-46-1)  
anethole  ·  1-methoxy-4-(1-propenyl)benzene  ·  p-propenylanisole
Anethole (anise camphor) is an organic compound that is widely used as a flavoring substance. It is a derivative of phenylpropene, a type of aromatic compound that occurs widely in nature, in essential oils. It contributes a large component of the odor and flavor of anise and fennel (both in the botanical family Apiaceae), anise myrtle (Myrtaceae), liquorice (Fabaceae), camphor, magnolia blossoms, and star anise (Illiciaceae).
acetohydroxamic acid (546-88-3)  
Lithostat  ·  Mission brand of acetohydroxamic acid  ·  Robert brand of acetohydroxamic acid
Acetohydroxamic acid (also known as AHA or Lithostat) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme.
4,4'-Sulfonyldiphenol (80-09-1)  
bis(4-hydroxyphenyl)sulfone  ·  bisphenol S
Bisphenol S (BPS) is an organic compound with the formula (HOC6H4)2SO2. It has two phenol functional groups on either side of a sulfonyl group. It is commonly used in curing fast-drying epoxy resin adhesives.
Medroxyprogesterone acetate (71-58-9)  
Provera  ·  DepoProvera  ·  Depo Provera
Medroxyprogesterone acetate (MPA), sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. It is used as birth control and as part of menopausal hormone therapy. It is also used to treat endometriosis, abnormal uterine bleeding, abnormal sexuality in males, and certain types of cancer.
ZEARALENONE (17924-92-4, 36455-70-6)  
F2 Toxin  ·  F-2 Toxin  ·  F 2 Toxin
Zearalenone (ZEN), also known as RAL and F-2 mycotoxin, is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Particularly, is produced by Fusarium graminearum, Fusarium culmorum, Fusarium cerealis, Fusarium equiseti, Fusarium verticillioides, and Fusarium incarnatum. Several Fusarium species produce toxic substances of considerable concern to livestock and poultry producers, namely deoxynivalenol, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and zearalenone.
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