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www.sigmaaldrich.com, Musculoskeletal system drug

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Drugs acting on the musculoskeletal system (47)
Drugs acting on the nervous system (33)
Anti-inflammatory and antirheumatic products (26)
Analgesics (25)
Anti-inflammatory agents (25)
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Nonsteroidal anti-inflammatory drugs (23)
Pharmaceuticals (22)
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Five-membered rings (3)
Pyridines (3)
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Dermatologic drug (1)
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TCI Chemicals (20)
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Accela (1)

Capsaicin (404-86-4)  
Zostrix  ·  Capzasin  ·  Capsin
Capsaicin ( (INN); 8-methyl-N-vanillyl-6-nonenamide) is an active component of chili peppers, which are plants belonging to the genus Capsicum. It is an irritant for mammals, including humans, and produces a sensation of burning in any tissue with which it comes into contact. Capsaicin and several related compounds are called capsaicinoids and are produced as secondary metabolites by chili peppers, probably as deterrents against certain mammals and fungi.
Aspirin (50-78-2)  
Acetylsalicylic Acid  ·  Ecotrin  ·  Zorprin
Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation. Specific inflammatory conditions in which aspirin is used include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin given shortly after a heart attack decreases the risk of death.
ibuprofen (15687-27-1)  
Motrin  ·  Rufen  ·  Nuprin
Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. About 60% of people improve with any given NSAID, and it is recommended that if one does not work then another should be tried.
ketorolac (66635-83-4, 74103-06-3)  
Ketorolac, sold under the brand name Toradol among others, is a nonsteroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives, used as an analgesic. It is considered a first-generation NSAID. Ketorolac acts by inhibiting the bodily synthesis of prostaglandins.
sulfinpyrazone (57-96-5)  
Anturane  ·  Sulphinpyrazone  ·  Anturan
Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane. Like other uricosurics, sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney.
METAXALONE (1665-48-1)  
Skelaxin  ·  AHR 438
Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.
chlorzoxazone (95-25-0)  
Parafon  ·  Paraflex  ·  Parafon Forte DSC
Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold under the trade names "'Lorzone'", Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol).
3-aminopropionitrile (151-18-8, 68130-65-4, 68130-66-5)  
Aminopropionitrile  ·  BAPN  ·  beta-Aminopropionitrile
Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional groups. It is a colourless liquid. The compound occurs naturally and is of interest in the biomedical community.
chlormezanone (102818-67-7, 80-77-3, 102818-66-6)  
Chlormethazanone
Chlormezanone (marketed under the brandname Trancopal or Fenaprim) is a drug used as an anxiolytic and a muscle relaxant. Its use was discontinued in many countries from 1996 on, due to rare but serious cases of toxic epidermal necrolysis.
niflumic acid (4394-00-7)  
Donalgin  ·  UPSA Conseil Brand of Niflumic Acid  ·  Nifluril
Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels.
flufenamic acid (530-78-9)  
Dignodolin
Flufenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins. Flufenamic acid is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6. It is not widely used in humans as it has a high rate (30-60%) of gastrointestinal side effects.
Cinchophen (132-60-5)  
Atofan  ·  aciphenochinolium
Cinchophen (trade names Atophan, Quinophan, and Phenaquin) is an analgesic drug that was introduced in 1910 and frequently used to treat gout. This drug is still used, in combination with Prednisolone, by veterinarians to treat arthritis in animals. It can be prepared starting from anilin, benzaldehyde and pyruvic acid in absolute ethanol.
(S)-(+)-Ibuprofen (51146-56-6)  
Dexibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It is the active dextrorotatory enantiomer of ibuprofen. Most ibuprofen formulations contain a racemic mixture of both isomers.
tiaprofenic acid (103667-49-8, 33005-95-7)  
Surgam  ·  Nu-Tiaprofenic  ·  tiaprofenic acid, calcium salt
Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended in children.
2-ETHOXYBENZAMIDE (938-73-8)  
2-ethoxy-benzamide  ·  ethenzamide  ·  o-ethoxybenzamide
Ethenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains. It is an ingredient in numerous cold medications and many prescription analgesics.
tolfenamic acid (13710-19-5)  
Rociclyn  ·  Zambon brand of tolfenamic acid  ·  Clotam
Tolfenamic acid (Clotam) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland. Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins. It is used in the UK as a treatment for migraine.
Aceclofenac (89796-99-6)  
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.
4-BIPHENYLACETIC ACID (5728-52-9)  
biphenylacetic acid  ·  felbinac  ·  biphenylylacetic acid
Felbinac (INN, or biphenylylacetic acid) is a topical medicine, belonging to the family of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs) of the arylacetic acid (not arylpropionic acid) class, which is used to treat muscle inflammation and arthritis. It is an active metabolite of fenbufen.
fenbufen (36330-85-5)  
Lederfen  ·  Cinopal  ·  gamma-oxo(1,1'-biphenyl)-4-butanoic acid
Fenbufen is a nonsteroidal anti-inflammatory drug in the propionic acid derivatives class. It was introduced by American Cyanamid under the trade name Lederfen in the 1980s and was withdrawn from markets in the developed world due to liver toxicity in 2010. As of 2015 it was available in Taiwan and Thailand under several brand names.
Neridronic acid (79778-41-9)  
Neridronic acid (INN; the anion is called neridronate) is a bisphosphonate. In Italy it is used to treat Osteogenesis imperfecta and Paget's disease of bone. A 2013 clinical trial suggests CRPS Type I (Complex regional pain syndrome) responds to treatment with intravenous neridronate.
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