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Alkaloids, Analgesic

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Analgesics (12)
Drugs acting on the nervous system (12)
Psychoactive drugs (11)
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Alkaloid (3)
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Alkenes (2)
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codeine (52-28-8, 76-57-3)  
Codeine Phosphate  ·  Isocodeine  ·  Ardinex
Isocodeine is an opioid research chemical related to codeine. It is an epimer of codeine that can be prepared from it by a Mitsunobu reaction. Dozens of derivatives and analogs of isocodeine and the related compound isomorphine have been produced.
morphine (64-31-3, 57-27-2)  
Morphia  ·  Morphine Sulfate  ·  MS Contin
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals. It acts directly on the central nervous system (CNS) to decrease the feeling of pain. It can be taken for both acute pain and chronic pain.
Matrine (519-02-8)  
Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism. Matrine possesses strong antitumor activities in vitro and in vivo.
THEBAINE (115-37-7)  
Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, Thēbai (Thebes), an ancient city in Upper Egypt. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning.
Rutaecarpine (84-26-4)  
Rutecarpine or rutaecarpine is a COX-2 inhibitor isolated from Euodia ruticarpa.
Isocodeine (509-64-8)  
Codeine  ·  Codeine Phosphate  ·  Ardinex
Isocodeine is an opioid research chemical related to codeine. It is an epimer of codeine that can be prepared from it by a Mitsunobu reaction. Dozens of derivatives and analogs of isocodeine and the related compound isomorphine have been produced.
Pukateine (81-67-4)  
Pukateine is an alkaloid found in the bark of the New Zealand tree Laurelia novae-zelandiae ("Pukatea"). An extract from pukatea is used in traditional Māori herbal medicine as an analgesic, and it is thought pukateine is the active component, as it is similar in both structure and activity to alkaloids such as glaucine and tetrahydropalmatine which are found in Chinese medicinal herbs used as analgesics. Pukateine has multiple mechanisms of action, with the most prominent effects being as an agonist at the D2 dopamine receptor and antagonist at the α1-adrenergic receptor.
CORONARIDINE (467-77-6)  
coronardine monohydrochloride  ·  coronardine monohydrochloride, (+-)-isomer  ·  coronardine
Hodgkinsine (18210-71-4)  
Hodgkinsine is an alkaloid found in plants of the Psychotria genus, particularly Psychotria colorata, although it is also found in Psychotria lyciiflora and probably other species in this family, as well as in the related species Calycodendron milnei. Hodgkinsine has antiviral, antibacterial and antifungal effects, but has mainly been researched for the analgesic effects that it produces, and is thought to be one of the components responsible for the analgesic effects seen when Psychotria colorata is used in traditional medical practice in humans. It has been found to act as both a mu opioid agonist and an NMDA antagonist, both of which are mechanisms of action shared with commonly used painkillers (morphine and ketamine respectively, and which occur concurrently in the clinical analgesics tramadol and levorphanol).
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Alkaloids
Analgesic