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Alkaloids, Quaternary ammonium compounds, Macrocycles, Cyclic compounds


Drugs acting on the musculoskeletal system (2)
Drugs acting on the nervous system (2)
Muscle relaxants (2)
Neuromuscular blockers (2)
Neurotoxins (2)
Quaternary compounds (2)

Curarine (22260-42-0)  
curarine dichloride, (1beta)-isomer  ·  curarine dichloride, (1beta)-(+-)-isomer  ·  curarine diiodide, (1beta)-isomer
Curare or is a common name for various plant extract alkaloid arrow poisons originating from Central and South America. These poisons function by competitively and reversibly inhibiting the nicotinic acetylcholine receptor (nAChR), which is a subtype of acetylcholine receptor found at the neuromuscular junction. This causes weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm.
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