Cyclic compounds (6)
Drug culture (3)
TCI Chemicals (1)
Hyoscine (51-34-3, 138-12-5)
Scopolamine · Scopolamine Hydrobromide · Transderm Scop
Hyoscine · Scopolamine Hydrobromide · Transderm Scop
Anisodine, also known as daturamine and α-hydroxyscopolamine, is an antispasmodic and anticholinergic drug used in the treatment of acute circulatory shock in China. It is a tropane alkaloid and is found naturally in species of the Solanaceae family of plants. Anisodine acts as a muscarinic acetylcholine receptor antagonist and α1-adrenergic receptor agonist.
Scopine is a tropane alkaloid found in a variety of plants including Mandragora root, Senecio mikanoides (Delairea odorata), Scopolia carniolica, and Scopolia lurida. Scopine can be prepared by the hydrolysis of scopolamine. It can also be prepared in three steps from N-methoxycarbonylpyrrole and 1,1,3,3-tetrabromoacetone; the reagents are combined in a [4+3] cycloaddition, followed by a diastereoselective reduction with diisobutylaluminum hydride, and finally a Prilezhaev epoxidation with trifluoroperacetic acid affords scopine.