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Alkaloids, www.sigmaaldrich.com

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Drugs acting on the nervous system (28)
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colchicine (64-86-8)  
Colchicine, (+-)-Isomer  ·  Colchicine, (R)-Isomer
Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as "meadow saffron"). Adverse effects are primarily gastrointestinal upset at high doses.
L-tryptophan (153-94-6, 73-22-3)  
Tryptophan  ·  Optimax  ·  L Tryptophan
Tryptophan (abbreviated as Trp or W; encoded by the codon UGG) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a non-polar aromatic amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet.
Ephedrine (134-72-5, 299-42-3)  
Ephedrine Sulfate  ·  Ephedrine Hydrochloride  ·  Ephedrine Renaudin
Ephedrine is a medication and stimulant. It is often used to prevent low blood pressure during spinal anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment.
PSEUDOEPHEDRINE (345-78-8, 90-82-4)  
Sudafed  ·  Pseudoephedrine Hydrochloride  ·  Pseudoephedrine HCl
Pseudoephedrine (; PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations, either as a single ingredient or (more commonly) in combination with antihistamines, guaifenesin, dextromethorphan, and/or paracetamol (acetaminophen) or an NSAID (such as aspirin or ibuprofen).
Melatonin (8041-44-9, 73-31-4)  
Melatonin, also known as N-acetyl-5-methoxy tryptamine, is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness. Melatonin is also produced in plants where it functions as a first line of defense against oxidative stress. In animals, melatonin is involved in the entrainment (synchronization) of the circadian rhythms including sleep-wake timing, blood pressure regulation, seasonal reproduction, and many others.
papaverine (61-25-6, 58-74-2)  
Papaverine Hydrochloride  ·  Pavabid  ·  Cerespan
Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm, vasospasm (especially those involving the intestines, heart, or brain), and occasionally in the treatment of erectile dysfunction. It is used in the treatment of acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic (morphine-related) opium alkaloids (opiates).
ATROPINE (13269-35-7, 51-55-8, 101-31-5, 5908-99-6)  
Atropine Sulfate  ·  Atropine Sulfate Anhydrous  ·  Atropin Augenöl
Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia.
(-)-Norephedrine (492-41-1, 14838-15-4, 700-65-2)  
Phenylpropanolamine  ·  Phenylpropanolamine Hydrochloride  ·  Norephedrine
Norephedrine (36393-56-3, 14838-15-4, 37577-28-9, 700-65-2)  
Phenylpropanolamine  ·  Phenylpropanolamine Hydrochloride  ·  Dexatrim
Phenylpropanolamine (PPA) is a sympathomimetic agent which is used as a decongestant and appetite suppressant. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs.
BRUCINE (357-57-3)  
dimethoxystrychnine  ·  10,11-dimethoxystrychnine  ·  bruzin
Brucine, an alkaloid closely related to strychnine, is most commonly found in the Strychnos nux-vomica tree. Brucine poisoning is rare, since it is usually ingested with strychnine, and strychnine is more toxic than brucine. In synthetic chemistry, it can be used as a tool for stereospecific chemical syntheses.
Phenethylamine (64-04-0)  
2-phenethylamine  ·  phenethylamine hydrobromide  ·  phenethylamine sulfate (2:1)
Phenethylamine (PEA), also known as β-phenylethylamine (β-PEA) and 2-phenylethan-1-amine, is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans. Phenylethylamine functions as a monoaminergic neuromodulator and, to a lesser extent, a neurotransmitter in the human central nervous system. It is biosynthesized from the amino acid L-phenylalanine by enzymatic decarboxylation via the enzyme aromatic L-amino acid decarboxylase.
protopine (130-86-9)  
fumarine  ·  protopine mesylate  ·  4,6,7,14-tetrahydro-5-methyl-bis(1,3)benzodioxolo(4,5-c-5',6'-g)azecin-13(5H)-one
Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
tyramine (51-67-2)  
p-Tyramine  ·  4-(2-Aminoethyl)phenol  ·  4 Hydroxyphenethylamine
Tyramine (also spelled tyramin) ( TY-rə-meen), also known by several other names, is a naturally occurring trace amine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent. Notably, it is unable to cross the blood-brain barrier, resulting in only non-psychoactive peripheral sympathomimetic effects following ingestion.
imidazole (288-32-4)  
imidazolium chloride  ·  imidazole acetate  ·  imidazole sodium
Imidazole is an organic compound with the formula C3N2H4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and having non-adjacent nitrogen atoms.
RETRONECINE (480-85-3)  
Retronecine is a pyrrolizidine alkaloid found in a variety of plants in the genera Senecio and Crotalaria, and the family Boraginaceae. It is the most common central core for other pyrrolizidine alkaloids.
noscapine (6035-40-1, 128-62-1, 912-60-7)  
Narcotine  ·  Noscapine Hydrochloride  ·  Dreluso Brand of Noscapine Hydrochloride
Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid from plants of the poppy family, without painkilling properties. This agent is primarily used for its antitussive (cough-suppressing) effects.
camptothecin (7689-03-4)  
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E.
Spirosol-5-en-3-ol (126-17-0)  
solasodine  ·  solasodine, (3beta,22beta,25S)-isomer  ·  solasodine citrate, (3alpha,22alpha,25R)-isomer
Solasodine is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasonine and solamargine are glycoalkaloid derivatives of solasodine. Solasodine is teratogenic to hamster fetuses in a dose of 1200 to 1600 mg/kg.
Cordycepin (75808-67-2, 73-03-0)  
3'-deoxyadenosine
Cordycepin, or 3'-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the absence of the hydroxy group in the 3' position of its ribose part. It was initially extracted from the fungus Cordyceps militaris, but is now produced synthetically. Because cordycepin is similar to adenosine, some enzymes cannot discriminate between the two.
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